Neurodegeneration

Neurodegeneration Researchers:

Yvonne Nolan, Gerard O’Keeffe, André Toulouse, Louise Collins.

• Astroglial heterogeneity and role of astroglial in neuron's degeneration.
• Development of in vivo and in vitro models of cyclopamine-mediated models of oli-godendrocyte depletion and demyelination.
• Study of mechanisms of cytotoxicity in spinocerebellar ataxias and Huntington’s dis-ease.
• Mechanisms of neuronal cell death in Parkinson’s disease.
• Role of activated microglia and pro-inflammatory cytokines in degeneration of midbrain dopaminergic neurons pertinent to Parkinson’s disease.
• Identification of inflammation-induced intracellular signaling cascades mediating the death or survival of midbrain dopaminergic neurons and hippocampal precursor cells.
• Reorganization of dynastic circuitries and selective loss of neurons in the amygdala in human temporal lobe epilepsy (TLE) and experimental epilepsy.