2017

UCC Physiology Research in the News

23 Oct 2017

Research from the Department of Physiology, published this month in The Journal of Physiology, describes physiological deficits and compensation at play in a mouse model of Duchenne muscular dystrophy (DMD), a devastating neuromuscular disease affecting about 1:3,500 live male births. 

Research from the Department of Physiology, published this month in The Journal of Physiology, describes physiological deficits and compensation at play in a mouse model of Duchenne muscular dystrophy (DMD), a devastating neuromuscular disease affecting about 1:3,500 live male births. The research paves the way for a better understanding of the control of breathing in DMD, with the potential to consider new treatment options. PhD trainee David Burns working with Professor Ken O’Halloran, and colleagues at the University of Calgary and Trinity College Dublin discovered that deficits arising from dystrophin deficiency are partly compensated by improved nervous system control of respiratory muscles. If this intrinsic compensatory response can be exploited it may offer therapeutic potential in the treatment of DMD.

The research article is available here: http://onlinelibrary.wiley.com/doi/10.1113/JP274792/abstract;jsessionid=4B2EB3F1A66BD3A1D4DA186C2401704F.f04t04

See press commentaries: https://wiley.altmetric.com/details/26630210/news

The research was featured in UCC news and views:  https://www.ucc.ie/en/about/uccnews/

Physiology Department

Fiseolaíocht

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