Neurogastroenterology recent publications

• Drugs, genes and the blues: Pharmacogenetics of the antidepressant response from mouse to man Review Article. Pharmacology Biochemistry and Behavior,  Available online 24 October 2013. Olivia F. O'Leary, Fionn E. O'Brien, Richard M. O'Connor, John F. Cryan
• Gut microbiota modulation and implications for host health: dietary strategies to influence the gut-brain axis Review Article. Innovative Food Science & Emerging Technologies, Available online 9 November 2013. Tatiana Milena Marques, John F. Cryan, Fergus Shanahan, Gerald F. Fitzgerald, R. Paul Ross, Timothy G. Dinan, Catherine Stanton
• Adult siRNA-induced knockdown of mGlu₇ receptors reduces anxiety in the mouse Original Research Article Neuropharmacology, Volume 72, September 2013, Pages 66-73
  Richard M. O'Connor, Deepak R. Thakker, Markus Schmutz, Herman van der Putten, Daniel Hoyer, Peter J. Flor, John F. Cryan
• Activation but not blockade of GABA_B receptors during early-life alters anxiety in adulthood in BALB/c mice Original Research Article Neuropharmacology, Available online 17 September 2013 Fabian F. Sweeney, Olivia F. O'Leary, John F. Cryan
• Psychobiotics: A Novel Class of Psychotropic Review Article Biological Psychiatry, Volume 74, Issue 10, 15 November 2013, Pages 720-726 Timothy G. Dinan, Catherine Stanton, John F. Cryan
• Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system Original Research Article
  Biomaterials, Volume 35, Issue 1, January 2014, Pages 489-499 Bruno M.D.C. Godinho, David J. McCarthy, Cristina Torres-Fuentes, Caroll J. Beltrán, Joanna McCarthy, Aoife Quinlan, Julien R. Ogier, Raphael Darcy, Caitriona M. O'Driscoll, John F. Cryan
• Su2111 A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits
  Gastroenterology, Volume 144, Issue 5, Supplement 1, May 2013, Page S-561 Paul J. Kennedy, Gerard Clarke, Andrew P. Allen, Ann O'Neill, John A. Groeger, Eamonn M. Quigley, Fergus Shanahan, John F. Cryan, Timothy G. Dinan
• Toll-like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice Original Research Article
  Biological Psychiatry, In Press, Accepted Manuscript, Available online 11 November 2013 Monica Tramullas, Beate C. Finger, Rachel D. Moloney, Anna V. Golubeva, Gerard Moloney, Timothy G. Dinan, John F. Cryan
• Unraveling the Longstanding Scars of Early Neurodevelopmental Stress
  Biological Psychiatry, Volume 74, Issue 11, 1 December 2013, Pages 788-789 John F. Cryan, Timothy G. Dinan
• GABA_B receptor ligands do not modify conditioned fear responses in BALB/c mice
  Behavioural Brain Research, Volume 256, 1 November 2013, Pages 151-156 Fabian F. Sweeney, Olivia F. O’Leary, John F. Cryan
• Therapeutic potential of GABA_B receptor ligands in drug addiction, anxiety, depression and other CNS disorders Review Article
  Pharmacology Biochemistry and Behavior, Volume 110, September 2013, Pages 174-184 Kushal Kumar, Sorabh Sharma, Puneet Kumar, Rahul Deshmukh
• Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment Original Research Article Neuropharmacology, Volume 66, March 2013, Pages 236-241 Richard M. O' Connor, Matteo M. Pusceddu, Timothy G. Dinan, John F. Cryan
• Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action Original Research Article
  Pharmacology Biochemistry and Behavior, Volume 103, Issue 3, January 2013, Pages 561-567 Richard M. O'Connor, Matteo M. Pusceddu, Olivia F. O'Leary, Helene M. Savignac, Javier A. Bravo, Malika El Yacoubi, Jean-Marie Vaugeois, Timothy G. Dinan, John F. Cryan
• Chapter Thirteen - Ghrelin At the Interface of Obesity and Reward
  Vitamins & Hormones, Volume 91, 2013, Pages 285-323 Harriët Schellekens, Timothy G. Dinan, John F. Cryan

Neurodegeneration recent publications

Louise M Collins, Aisling M Gavin, Sinead Walsh, Aideen M Sullivan, Sean L Wyatt, Gerard W O'Keeffe, Yvonne M Nolan, André Toulouse. Expression of endogenous Mkp1 in 6-OHDA rat models of Parkinson's disease. SpringerPlus 2014, 3:205

Collins, L.M., O'Keeffe, G.W., Long-Smith, C.M., Wyatt, S.L., Sullivan, A.M., Toulouse, A., Nolan, Y.M. (2013) Mitogen-activated protein kinase phosphatase (MKP)-1 as a neuroprotective agent: promotion of the morphological development of midbrain dopaminergic neurons. Neuromol Med. 15:435-46. PMID: 23584919.

Developmental Neuroscience - Regeneration recent publications

• Dmitriev RI, Zhdanov AV, Nolan YM, Papkovsky DB. (2013) Imaging of neurosphere oxygenation with phosphorescent probes. Biomaterials 34: 9307-9317
• Hegarty, S.V., O'Keeffe, G.W., Sullivan, A.M. (2013) BMP-Smad 1/5/8 signalling in the development of the nervous system. Prog Neurobiol.109; 28-41. PMID: 23891815
• Hegarty, S.V., Sullivan, A.M., O'Keeffe, G.W. (2013) BMP2 and GDF5 induce neuronal differentiation through a Smad dependant pathway in a model of human midbrain dopaminergic neurons.Mol Cell Neurosci. 56: 263-271. PMID: 23831389
• Hegarty, S.V., Sullivan, A.M., O'Keeffe, G.W. (2013) Midbrain dopaminergic neurons: A review of the molecular circuitry that regulates their development. Dev Biol. 379:123-38. PMID: 23603197

Recent Press Cuttings

Filling the void: our difficult relationship with food

Do you reward yourself with a slice of cake for a job well done, or reach for the biscuit tin in stressful moments?

IRISH TIMES 8th NOV 2013

http://www.irishtimes.com/life-and-style/food-and-drink/filling-the-void-our-difficult-relationship-with-food-1.1588553

Harnessing the potential of new brain cells

 SILICONREPUBLIC.COM0 8.11.2013

Dr Yvonne Nolan is looking at how neurons grow in adult brains, and how we might be able to target them to improve health or address disease

http://siliconrepublic.com/special-events/women-invent-tomorrow/news/item/34760-wit2013

UCC’s Dr Eric Downer has received a Neuroscience Ireland Early Career Investigator Award for his pioneering research into the cannabinoid system and how it can contribute to treating multiple sclerosis. http://www.ucc.ie/en/news/fullstory-371719-en.html

http://thecorknews.ie/articles/ucc-lecturer-honoured-ms-research-12358

Dara O Briain's Science Club

http://www.bbc.co.uk/programmes/b039c6b9

‘Psychobiotics’ offer potential in improving mental health, researchers find

 IRISH TIMES JUNE 18 2013

http://www.irishtimes.com/news/health/psychobiotics-offer-potential-in-improving-mental-health-researchers-find-1.1432233

Irish scientists leading street drug research

Tuesday, April 30, 2013

STREET drugs, such as ecstasy (MDMA) and cannabis, are being examined for their medicinal value.

http://www.irishexaminer.com/lifestyle/features/high-ideals-229863.html

Anatomical Society Best Image 2013

Dr Kieran McDermott and Dr Janelle Pakan win the Anatomical Society Best Image Prize 2013

http://www.anatsoc.org.uk/Awards/GrantsandPrizes/AnatomicalSocietyBestImagePrize/WinnersMay2012.aspx

Title: Embryonic Spinal Cord. Description: Confocal image of nestin (red) positive radial neuroepithelial cells dorsally and co-localized nestin (red) and BLBP (green) positive radial glial cells ventrally in an 40 micron transverse section of the E14 rat spinal cord. Cell nuclei are labelled with bisbenzimide (blue)

‌Gut feeling about better health

Recent Press Releases 2013

9th Sept 2013 Stressed out Memories Beyond the Gut in Irritable Bowel Syndrome

29 August APC 29 August 2013 APC SCIENTSIST FEATURE DARA O BRIAIN

21 May 2013 A Gut feeling about Autism

20 November 2012 UCC RESEARCH AWARD FOR SCIENTIST

28 March 2012 MAR 2012 Bruno Wins UCC Science for All competition

12 July 2011UCC RESEARCH AWARD FOR SCIENTIST