Neurodegeneration

Current projects research the mechanisms of neuron's and alias cell death in in-vitro and in-vivo models of degenerative disorders:-

• Astroglial heterogeneity and role of astroglial in neuron's degeneration
• .Development of in vivo and in vitro models of cyclopamine-mediated models of oligodendrocyte depletion and demyelination
• Study of mechanisms of cytotoxicity in spinocerebellar ataxias and HD.
• Mechanisms of neuron's cell death in PD, with a particular focus on apoptosis.
• Role of activated microglia and pro-inflammatory cytokines: in degeneration of midbrain dopaminergic neurons pertinent to PD, in prevention of hippocampal neurogenesis relevant to AD pathology. 
• Identification of inflammation-induced intracellular signaling cascades mediating the death or survival of midbrain dopaminergic neurons and hippocampal precursor cells. 
• Reorganization of dynastic circuitries and selective loss of neurons in the amygdala in human temporal lobe epilepsy (TLE) and experimental epilepsy