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Neurogastroenterology
Neurogastroenterology
Current research interests include the neurobiological basis of stress-related neuropsychiatric disorders including depression, anxiety and drug dependence. Moreover, his group is also focused on understanding the interaction between brain and gut and how it applies to stress and immune-related disorders, including irritable bowel syndrome, obesity and sepsis. He is also interested in applying novel approaches to facilitate drug/siRNA delivery to the brain in vivo.
Dr. Cryan's research group iand consists of 4 Postdoctoral Fellows, 14 PhD students, 1 MSc Students, 3 research scientists and various visiting students from Ireland, Spain, The Netherlands, USA & Canada. It is funded by Science Foundation Ireland, the Health Research Board, Enterprise Ireland and the Irish Research Council for Science, Engineering and Technology. Moreover, Dr. Cryan receives funding as a Pi on the EU Framework 7 Programme grant "Devanx" focused on understanding the role of brain serotonin and GABAB receptors in anxiety: from developmental risk factors to treatment (http://devanx.vitamib.com).
Neurogastroenterology recent publications
- Drugs, genes and the blues: Pharmacogenetics of the antidepressant response from mouse to man Review Article. Pharmacology Biochemistry and Behavior, Available online 24 October 2013. Olivia F. O'Leary, Fionn E. O'Brien, Richard M. O'Connor, John F. Cryan
- Gut microbiota modulation and implications for host health: dietary strategies to influence the gut-brain axis Review Article. Innovative Food Science & Emerging Technologies, Available online 9 November 2013. Tatiana Milena Marques, John F. Cryan, Fergus Shanahan, Gerald F. Fitzgerald, R. Paul Ross, Timothy G. Dinan, Catherine Stanton
- Adult siRNA-induced knockdown of mGlu7 receptors reduces anxiety in the mouse Original Research Article Neuropharmacology, Volume 72, September 2013, Pages 66-73
Richard M. O'Connor, Deepak R. Thakker, Markus Schmutz, Herman van der Putten, Daniel Hoyer, Peter J. Flor, John F. Cryan - Activation but not blockade of GABAB receptors during early-life alters anxiety in adulthood in BALB/c mice Original Research Article Neuropharmacology, Available online 17 September 2013 Fabian F. Sweeney, Olivia F. O'Leary, John F. Cryan
- Psychobiotics: A Novel Class of Psychotropic Review Article Biological Psychiatry, Volume 74, Issue 10, 15 November 2013, Pages 720-726 Timothy G. Dinan, Catherine Stanton, John F. Cryan
- Differential nanotoxicological and neuroinflammatory liabilities of non-viral vectors for RNA interference in the central nervous system Original Research Article
Biomaterials, Volume 35, Issue 1, January 2014, Pages 489-499 Bruno M.D.C. Godinho, David J. McCarthy, Cristina Torres-Fuentes, Caroll J. Beltrán, Joanna McCarthy, Aoife Quinlan, Julien R. Ogier, Raphael Darcy, Caitriona M. O'Driscoll, John F. Cryan - Su2111 A Prospective Assessment of Cognitive Performance in Irritable Bowel Syndrome Reveals Persistent Visuospatial Memory Deficits
Gastroenterology, Volume 144, Issue 5, Supplement 1, May 2013, Page S-561 Paul J. Kennedy, Gerard Clarke, Andrew P. Allen, Ann O'Neill, John A. Groeger, Eamonn M. Quigley, Fergus Shanahan, John F. Cryan, Timothy G. Dinan - Toll-like Receptor 4 Regulates Chronic Stress-Induced Visceral Pain in Mice Original Research Article
Biological Psychiatry, In Press, Accepted Manuscript, Available online 11 November 2013 Monica Tramullas, Beate C. Finger, Rachel D. Moloney, Anna V. Golubeva, Gerard Moloney, Timothy G. Dinan, John F. Cryan - Unraveling the Longstanding Scars of Early Neurodevelopmental Stress
Biological Psychiatry, Volume 74, Issue 11, 1 December 2013, Pages 788-789 John F. Cryan, Timothy G. Dinan - GABAB receptor ligands do not modify conditioned fear responses in BALB/c mice
Behavioural Brain Research, Volume 256, 1 November 2013, Pages 151-156 Fabian F. Sweeney, Olivia F. O’Leary, John F. Cryan - Therapeutic potential of GABAB receptor ligands in drug addiction, anxiety, depression and other CNS disorders Review Article
Pharmacology Biochemistry and Behavior, Volume 110, September 2013, Pages 174-184 Kushal Kumar, Sorabh Sharma, Puneet Kumar, Rahul Deshmukh - Impact of early-life stress, on group III mGlu receptor levels in the rat hippocampus: Effects of ketamine, electroconvulsive shock therapy and fluoxetine treatment Original Research Article Neuropharmacology, Volume 66, March 2013, Pages 236-241 Richard M. O' Connor, Matteo M. Pusceddu, Timothy G. Dinan, John F. Cryan
- Hippocampal group III mGlu receptor mRNA levels are not altered in specific mouse models of stress, depression and antidepressant action Original Research Article
Pharmacology Biochemistry and Behavior, Volume 103, Issue 3, January 2013, Pages 561-567 Richard M. O'Connor, Matteo M. Pusceddu, Olivia F. O'Leary, Helene M. Savignac, Javier A. Bravo, Malika El Yacoubi, Jean-Marie Vaugeois, Timothy G. Dinan, John F. Cryan - Chapter Thirteen - Ghrelin At the Interface of Obesity and Reward
Vitamins & Hormones, Volume 91, 2013, Pages 285-323 Harriët Schellekens, Timothy G. Dinan, John F. Cryan