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High fat diet increases risk of food poisoning from Listeria monocytogenes

21 Jan 2019
Dr Cormac Gahan and Vanessa Las Heras, APC Microbiome Ireland, School of Microbiology and School of Pharmacy, University College Cork. Image: Tomas Tyner, UCC

APC Microbiome Ireland, School of Microbiology and School of Pharmacy scientists based at University College Cork have shown for the first time that a high fat “western” diet reduces the efficiency of the immune system to fight infectious disease particularly in the gut, and to infection with the foodborne pathogen, Listeria monocytogenes.

The researchers found that feeding mice with a “westernised” diet, which is high in fat and low in fermentable fibre, affected both the immune system and the bacteria resident in the gut (the gut microbiota). Even short-term consumption of the high fat diet was found to increase the number of goblet cells in the gut, which are the target for infection by Listeria, as well as causing profound changes to the microbiota composition and immune system. The high fat diet also increased susceptibility to infections beyond the gut.

Increased human consumption of a ‘westernized’ diet has been linked to the dramatic rise in conditions such as obesity and type 2 diabetes, and research has demonstrated the direct effects of dietary fats upon both the immune system and the gut microbiota.

Listeria monocytogenes is a human pathogen found in contaminated foods that can cause serious disease, particularly in pregnant women, the elderly and immunocompromised people.

“Short-term consumption of the high fat diet increased levels of Firmicutes bacteria in the gut which are associated with obesity” said PhD student Vanessa Las Heras, who carried out the study at the flagship Science Foundation Ireland Research Centre. “The effects of diet were also seen beyond the gut, with reduced levels of immunity throughout the body, local alterations to gastrointestinal cell function and changes to the gut microbiota that enhanced the progression of Listeria infection”.

“Our results suggest that diet may be a significant influencer of resistance to infectious disease through effects on the gut microbiota and immune system.  This has important implications for human health, especially during pregnancy, in old age and in immunocompromised individuals.  It also has more general implications for research on infectious disease” said Dr Cormac Gahan, leader of the research study.

This research was funded through an EU Horizon 2020 Innovative Training Network grant and by Science Foundation Ireland through a Research Centre grant to APC Microbiome Ireland.

The study is published in the journal Microbiome:

Las Heras V, Clooney AG, Ryan FJ, Cabrera-Rubio R, Casey P, Hueston CM, Pinheiro J, Rudkin JK, Melgar S, Cotter PD, Hill C, and Gahan CGM. 2019. Short-term consumption of a high fat diet increases host susceptibility to Listeria monocytogenes infection. Microbiome20197:7

For more on this story contact:

For further information please contact Dr Cormac Gahan tel +353 21 3901363; mobile +353 86 8114658; email: or Dr Catherine Buckley, Communications Manager, APC Microbiome Ireland, UCC tel +353 21 4903362; mobile +353 86 8554744; email

School of Microbiology

Scoil na Micribhitheolaíochta

Microbiology Office, Room FSB452, 4th Floor Food Science & Technology Building, University College Cork, Cork T12 Y337