2025 Publications

1. The class-IIa HDAC inhibitor TMP269 promotes BMP-Smad signalling and is neuroprotective in in vitro and in vivo 6-hydroxydopamine models of Parkinson's disease 

O'Mahony, A.G., Mazzocchi, M., Morris, A., Morales-Prieto, N., Guinane, C., Wyatt, S.L., Collins, L.M., Sullivan, A.M., * O'Keeffe, G.W.* (2025) The class-IIa HDAC inhibitor TMP269 promotes BMP-Smad signalling and is neuroprotective in in vitro and in vivo 6-hydroxydopamine models of Parkinson's disease. Neuropharmacology. 2025 Jan 20:110319

2. Discovery of Sphingosine Kinase Inhibition by Modified Quinoline-5,8-Diones

Kruschel, R. D., Malone, K., Walsh, A. N., Waeber, C., & McCarthy, F. O. (2025). Discovery of Sphingosine Kinase Inhibition by Modified Quinoline-5,8-Diones. Pharmaceuticals, 18(2), 268.

3. From in silico screening to in vivo validation in zebrafish - a framework for reeling in the right psychobiotics

Valderrama B, Daly I, Gunnigle E, O'Riordan KJ, Chichlowski M, Banerjee S, Skowronski AA, Pandey N, Cryan JF, Clarke G, Nagpal J. From in silico screening to in vivo validation in zebrafish - a framework for reeling in the right psychobiotics. Food Funct. 2025 Feb 18.

4. Evaluating student understanding of core pharmacokinetic concepts

Babey AM, Koenig J, Cunningham M, Shield A, Restini C, Djouma E, Mraiche F, Mifsud J, Kelly JP, Nicolazzo J, Karpa KJ, Volbrecht K, Santiago MJ, Hawes M, Aljofan M, Kelly-Laubscher R, Karunaratne N, Tucker SJ, Hinton T, Liang W, Guilding C, White PJ. Evaluating student understanding of core pharmacokinetic concepts. Eur J Pharmacol. 2025 Mar 5;990:177256.

5. Evaluating student understanding of pharmacodynamics core concepts

Kelly-Laubscher R, Koenig J, Cunningham M, Aljofan M, Babey AM, Hawes M, Hinton T, Karpa K, Karunaratne N, Nicolazzo J, Liang W, Mraiche F, Restini C, Santiago M, Volbrecht K, Guilding C, White PJ. Evaluating student understanding of pharmacodynamics core concepts. Eur J Pharmacol. 2025 Mar 5;990:177257

6. Exploring the knowledge demands of a pharmacology assessment using Legitimation Code Theory

Pignatelli-Espejo A, Kelly-Laubscher R, Barry ÓP. Exploring the knowledge demands of a pharmacology assessment using Legitimation Code Theory. Eur J Pharmacol. 2025 Feb 23;996:177411

7. Behavioural assessment of neuropsychiatric outcomes in rodent stroke models

Callaghan RM, Yang H, Moloney RD, Waeber C. Behavioural assessment of neuropsychiatric outcomes in rodent stroke models. Journal of Cerebral Blood Flow & Metabolism. 2025;0(0).

8. IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning

Hernandez-Resendiz, S., Vilskersts, R., Aluja, D. Kelly-Laubscher, R et al. IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT): a small animal acute myocardial infarction randomized-controlled multicenter study on the effect of ischemic preconditioning. Basic Res Cardiol 120, 335–346 (2025).

9. Commercially available products for the digital tracking of biomarkers in Parkinson's Disease