International Biochemistry Conference for UCC

UCC Quadrangle

UCC Quadrangle

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May 11th is the last day for the early bird registration fee for the biochemistry conference on Rab GTPases, 11-13th June in UCC.

Rab GTPases localise to distinct cellular organelles and regulate all stages of intracellular membrane trafficking in eukaryotic cells. Their activity state and functional effects are controlled and or mediated by several interacting proteins, including guanine nucleotide exchange proteins, GTPase Activating proteins, effector and motor proteins. Rab GTPase function is essential for a vast range of normal cellular physiological processes, ranging from Long Term Potentiation (LTP) to cellular uptake of glucose in response to insulin signalling.

In recent years, Rabs, or their interactors, have been implicated in a wide range of genetic diseases. Some examples include choroideremia, Niemann-Pick disease, Griscelli syndrome, cancer aggressiveness, Charcot-Marie-Tooth disease, X-linked mental retardation, Huntingtin’s disease, Alzheimer’s disease, Batten’s disease, osteopetrosis, Crohn’s disease, diabetic nephropathy, cardiomyopathy, Carpenter’s syndrome, Sjogren’s syndrome and platelet disorders.

Furthermore, they are implicated in a lengthening list of host/pathogen diseases involving viruses, bacteria and parasitic pathogens.  Some examples of viral infections  include; Influenza-, Dengue-, West Nile-, Foot & mouth-, Coxsackie-, Encephalitis-, Hepatitis C-, Respiratory Syncytial- , Measles-, Hantavirus and Human Immunodeficiency Virus.  Examples of bacterial infections with which Rabs have been connected include Chlamydia, Brucella, Salmonella, Listeria, Helicobacter, Mycobacteria. Parasitic conditions with which the Rabs have been connected include Trypanosoma cruzei and brucei.

The meeting will include a keynote presentation on Rabs by Bruno Goud and review presentations on Ras and Rho proteins by Chris Marshall and Alan Hall, respectively.

This meeting will bring together researchers who work on the functional characterization of Rabs and / or their interacting proteins in either normal cellular physiology (health) or in diseases as well as an overview of Ras, Rho and Rab cellular function.

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