2007 Press Releases
UCC Academic Publishes in Prestigious Journal
17.10.2007
Professor Mary McCaffrey, Biochemistry Department, is a co-author on a paper in the current issue of the prestigious journal, Development Cell (Caswell, PT et al., 13, 496-510 (2007).
17.10.2007
Professor Mary McCaffrey, Biochemistry Department, is a co-author on a paper in the current issue of the prestigious journal, Development Cell (Caswell, PT et al., 13, 496-510 (2007).
The publication is the result of collaboration between Professor McCaffrey and Dr Jim Norman's group from the Beatson Institute for Cancer Research, Glasgow, UK.
For some years now, it has been known that the expression and function of Rab25 (Rab11c) determines the aggressiveness of ovarian and breast cancers (Cheng, KW., et al., Nature Medicine 11, 1251-1256 (2004). Professor McCaffrey's group is one of the world-leading groups in the functional characterization of the Rab11 proteins. As a result of the Cheng report, she was contacted by Dr Norman, an expert on the function of integrin proteins which are necessary for cell adhesion and motility, to exploit the functional interplay between Rab25(Rab11c) and the integrins.
The Development Cell paper identifies a direct interaction between Rab25 and b1 integrin. It also demonstrates that Rab25 promotes cell migration in three dimensional environments, indicating that Rab25 contributes to tumour progression by enhancing the invasive (metastatic) ability of tumour cells.
540MMMcS
For some years now, it has been known that the expression and function of Rab25 (Rab11c) determines the aggressiveness of ovarian and breast cancers (Cheng, KW., et al., Nature Medicine 11, 1251-1256 (2004). Professor McCaffrey's group is one of the world-leading groups in the functional characterization of the Rab11 proteins. As a result of the Cheng report, she was contacted by Dr Norman, an expert on the function of integrin proteins which are necessary for cell adhesion and motility, to exploit the functional interplay between Rab25(Rab11c) and the integrins.
The Development Cell paper identifies a direct interaction between Rab25 and b1 integrin. It also demonstrates that Rab25 promotes cell migration in three dimensional environments, indicating that Rab25 contributes to tumour progression by enhancing the invasive (metastatic) ability of tumour cells.
540MMMcS