ABCRF Research Interests
Areas of Interest - ABCRF Researchers
Prof Anita R Maguire
Organic and Pharmaceutical synthesis. Novel methodologies, asymmetric synthesis, medicinal chemistry, crystal engineering. a-Diazocarbonyl compounds and organosulfur compounds in synthesis. Biocatalysis and transition metal catalysis. Bioactive compounds with pharmaceutical applications
Prof Jeremy D Glennon
Analytical/Separation science. Including bio-chromatography and supercritical fluid extraction technology. Chelating solid phase materials and membranes for metal ion extraction. Macrocyclic and Hydroxamate Phases for Chromatography. Miniaturised Separation Devices for Environmental and Process Analysis.
Prof Dmitri Papkovsky
O2 in biology: metabolism, mitochondrial function, bioenergetics, hypoxia. Sensing/imaging of O2 in cells/tissues. O2 as a marker of cellular (dys)function: Application to cancer, neuroscience, environmental toxicology. Porphyrin-based sensors and probes. Phosphorescent materials. Advanced (bio)Materials, bioconjugate Chemistry.
Dr Eric Moore
Chemical and bio-sensing and separation. He is an Academic member within the Life Science Interface group at Tyndall National Institute, University College Cork.
Organic chemistry. Natural product synthesis with particular relevance to medicinal chemistry. Microwave assisted reactions of novel a-diazocarbonyl compounds. Semi-synthesis of lanosterol derivatives and total synthesis of neolamellarin analogues.
Dr Abina Crean
Drug delivery systems and solid-state engineering to enhance the bioavailability of therapeutic compounds. Solid-state characterisation techniques including thermal analysis and crystallography. Pharmaceutical processing technologies and drug physicochemical properties.
Dr Dara Fitzpatrick
Biophysical and Environmental science. Novel routes to trans-dermal delivery, particulate characterization and toxin analysis. Audible Sound Waves as a new form of Spectroscopy. Risk assessment and predictive modelling of exogenous compounds via the dermal route.
Dr JJ Keating
Pharmaceutical and Medicinal Chemistry. Impurity profiling of amphetamine-type drugs of abuse. Synthesis and biological activity of pharmacologically active natural products and their synthetic analogues.
Dr Simon Lawrence
Solid State Chemistry. Controlling matter at the nano-scale with emphasis on compounds of pharmaceutical interest. Structural control of the crystalline state, involving crystal engineering, supramolecular chemistry and polymorphism.
Dr Dan McCarthy
Organic Chemistry. Synthetic methodologies, kinetics and mechanisms. Molecular structure determination using NMR. Unsaturated organic compounds, heterocyclic chemistry, organic sulphur and selenium chemistry, reactive intermediates, organic reaction mechanisms, asymmetric synthesis.
Dr Florence McCarthy
Medicinal Chemistry. Drug discovery and cancer research strategies. Mass spectrometry applied to pharmaceutical analysis. Erb B, Wee 1, and Chk 1 kinase inhibitors for the treatment of cancer. Ellipticine and Phytosterol derivatives and their mechanism of biological effect. Molecular modelling and its application to medicinal chemistry.
Dr Justin McCarthy
Signalling pathways involved in the pathogenesis of disease. Cell signalling in normal/diseased tissue. Drug target discovery, validation and assay development. Identification/characterization of disease-relevant alterations in presenilin functions and how these may pertain to pathogenesis/progression of Alzheimer’s disease.
Dr Gerard P McGlacken
Organic and Pharmaceutical Chemistry. Molecular design and synthesis, new synthetic methodology and application to total synthesis and molecules of biological importance. Specifically, the asymmetric substitution of ketones and the area of C–H activation/direct arylation.
Dr Humphrey Moynihan
Organic Chemistry and Pharmaceutical Molecular Solids with emphasis on synthesis, crystallization and crystal polymorphism. The supramolecular structure of pharmaceutical solids, in particular crystallization, crystal form characterisation, polymorphism and related issues.
Dr Tim O’Sullivan
Pharmaceutical Chemistry. Development and optimisation of synthetic strategies towards biologically active products and the subsequent analogue synthesis. Novel, chiral tethers for the control of intramolecular, aryl-aryl coupling and their application to the synthesis of axially chiral biphenyls which display anti-HIV activity.