Professor Ines Thiele is the principal investigator of the Molecular Systems Physiology group at the National University of Ireland, Galway. Her research aims to improve the understanding of how diet influences human health. Therefore, she uses a computational modelling approach, termed constraint-based modelling, which has gained increasing importance in systems biology. Her group builds comprehensive models of human cells and human-associated microbes; then employs them together with experimental data to investigate how nutrition and genetic predisposition can affect one's health. In particular, she is interested in applying her computational modelling approach for better understanding of inherited and neurodegenerative diseases. Ines Thiele has been pioneering models and methods allowing large-scale computational modelling of the human gut microbiome and its metabolic effect on human metabolism.
Ines Thiele earned her PhD in bioinformatics from the University of California, San Diego, in 2009. Ines Thiele was an Assistant and Associate Professor at the University of Iceland (2009 - 2013), and Associate Professor at the University of Luxembourg (2013-2019).
In 2013, Ines Thiele received the ATTRACT fellowship from the Fonds National de la Recherche (Luxembourg). In 2015, she was elected as EMBO Young Investigator. In 2017, she was awarded the prestigious ERC starting grant. In 2020, Ines Thiele was named a highly cited researcher by Clarivate, and received the NUI Galway President’s award in research excellence. She is an author of over 100 international scientific papers and reviewer for multiple journals and funding agencies.
Theme: Host-Microbe Dialogue
Research key words: Computational modelling of host-microbiome co-metabolism, Metabolism, metabolic modelling, metagenomic data analysis, digital twin, Alzheimer's disease, Parkinson's disease, nutrition, inherited metabolic diseases, inflammatory bowel disease