Lorena Morales García
Project Title: Role of Maternal Gut-Microbiota in the neurovascular development of the hypothalamus
RO1: To evaluate the development, structure, and function of neurovascular interactions after gut microbiome disruption in prenatal life using germ-free (GF; lack of all microorganisms) mice and one translationally relevant disruptor: antibiotics administration (ABX).
RO2: To analyze the radial glial (RG) neural progenitor lineages of the alar hypothalamus and its RG-derived cell populations in GF and ABX mouse models.
RO3: To evaluate the microbiome-derived metabolites and the molecular mechanisms involved in microbiota- hypothalamic neurovascular communication.
Global societal challenge that you are tackling:
Non-communicative diseases (NCDs) or neurodevelopmental disorders