Project Title: Investigating the effects of an exercise intervention on the gut bacteria and mood in individuals with Major Depressive Disorder
- Understand how an exercise intervention effects measures of depression, negative biases and the gut microbiome in MDD, when compared to a control group of no intervention (usual care).
- Assess the relationships between the effects on the gut microbiome from the exercise intervention, and the changes in depressive symptoms, negative biases, and cognition in individuals with MDD.
- To determine the effects of an exercise intervention, on measures of immunity, inflammation, neurotransmitters and gut-microbially derived metabolites (i.e., short chain fatty acids) from blood and urine samples in individuals with MDD.
Global Societal challenge being addressed: This project is targeting the WHOs sustainable development goal 3, Good health and wellbeing, and specifically target 3.4 which aims to reduce mortality from non-communicable diseases, including depression. The current project will help achieve this goal by further understanding the mechanisms of additional therapeutic techniques for people with depression, aiding in a greater reduction in depression symptoms and achieving a larger precentage of remission, as currently, treatments are effective in only approx. 50% of people.