A review of reproductive outcomes of women with two consecutive miscarriages and no living child

A causative factor was identified in 29% of women with two consecutive miscarriages in our study. 82% had a subsequent pregnancy, with 73% achieving a live birth. We suggest that supportive care is the single most effective therapy for women with two consecutive miscarriages.

Deirdre Green, Keelin O'Donoghue
Journal Name
Journal of Obstetrics and Gynaecology
Journal Article
Recurrent miscarriage
Full Citation
Green DM, O’Donoghue K. A review of reproductive outcomes of women with two consecutive miscarriages and no living child. Journal of Obstetrics and Gynaecology. 2019;39(6):816-821.
Link to Publication


The definition of recurrent miscarriage ranges from two miscarriages according to the American Society for Reproductive Medicine and the European Society of Human Reproduction and Embryology, to three consecutive pregnancy losses as defined by the Royal College of Obstetricians and Gynaecologists. Recent guidelines emphasise the need for further research on the effect of various recurrent miscarriage definitions on diagnosis, treatment and prognosis. Our study examines the management and pregnancy outcomes of nulliparous women attending Cork University Maternity Hospital’s Pregnancy Loss Clinic, between 2009 and 2014, with their second consecutive first-trimester miscarriage. We sourced information from the Pregnancy Loss Clinic’s database, hospital patient management and laboratory systems, and clinical letters: 294 women were identified. A subsequent pregnancy was conceived by 82% (242/294) of women, with 73% (176/242) achieving a live birth. In conclusion, supportive care and selective medical management in dedicated pregnancy loss and early pregnancy clinics achieve excellent reproductive outcomes.

Pregnancy Loss Research Group

Pregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Fifth Floor, Cork University Maternity Hospital, Wilton, Cork, T12 YE02, Ireland,