Subsequent pregnancy outcomes following second trimester miscarriage—A prospective cohort study

Women with second-trimester miscarriage in our study had a notable rate of recurrence (6.3%). Second-trimester miscarriage is a risk factor for adverse pregnancy outcomes. It merits close observation during pregnancy, particularly women with a history of periviable loss.

Laura Linehan, Aoife Morris, Sarah Meaney, Keelin O'Donoghue
Journal Name
European Journal of Obstetrics, Gynecology, and Reproductive Biology (EJOG)
Journal Article
Second-trimester miscarriage
Full Citation
Linehan A, Morris AG, Meaney S, O’Donoghue K. Subsequent pregnancy outcomes following second trimester miscarriage—A prospective cohort study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2019;237:198-203.
Link to Publication


Second trimester miscarriage (miscarriage after 12 weeks) is an uncommon complication of pregnancy. Causes can include atypical genetics in the fetus, early silent dilating of the cervix, or very preterm labour. We examined the outcomes in a next pregnancy in 175 women who had experienced second-trimester miscarriage. Among 110 women who became pregnant in the study period 2009–2016, 6.3% had a further second-trimester miscarriage; the preterm birth rate (baby born before 37 weeks) was also 6.3%. The first-trimester miscarriage rate was 24%. Most women had a healthy livebirth in their first pregnancy following second-trimester miscarriage with 81 babies born to 77 mothers (77/110; 70%). Women with a history of second-trimester miscarriage are at increased risk of a further second-trimester miscarriage and should be monitored carefully in their next pregnancy, particularly if they lost their baby after 18 weeks gestation, were diagnosed with a short cervix or went into labour very prematurely.

Pregnancy Loss Research Group

Pregnancy Loss Research Group, Department of Obstetrics & Gynaecology, University College Cork, Fifth Floor, Cork University Maternity Hospital, Wilton, Cork, T12 YE02, Ireland,