Publications
Gestation-specific D-dimer reference ranges: a cross-sectional study
We found that there is a continuous increase in D-dimer concentrations across all gestations. This research is potentially beneficial to future diagnosis of venous thromboembolism in pregnancy using the new recommended 95th centile potential cut-offs.
- Authors
Keelin O'Donoghue
- Year
- 2014
- Journal Name
- British Journal of Obstetrics and Gynecology (BJOG)
- Category
- Journal Article
- Full Citation
Murphy, N, Broadhurst, DI, Khashan, AS, Gilligan, O, Kenny, LC, O'Donoghue, K. Gestation-specific D-dimer reference ranges: a cross-sectional study. British Journal of Obstetrics and Gynaecology. 2015;122: 395– 400. https://doi.org/10.1111/1471-0528.12855.
- Link to Publication
- https://doi.org/10.1111/1471-0528.12855
Abstract
We aimed to establish a gestation-specific reference range for D-dimer in healthy pregnant women with a singleton pregnancy using the Auto-Dimer assay. Seven hundred and sixty healthy pregnant women were investigated between gestational age week 5 and 48 hours postpartum attending for routine antenatal care at Cork University Maternity Hospital. There was a clear steady increase in median D-dimer concentrations over the complete gestational period. Additionally, the 95th centile estimates for all gestational time-points were above the accepted non-pregnancy normal cut-off concentration (224 ng/ml). Our results also suggested that the long-term postnatal return to normal D-dimer concentrations begins in the immediate postpartum period. This research is potentially beneficial to future diagnosis of venous thromboembolism in pregnancy using the new recommended 95th centile potential cut-offs.