Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia
The well-characterised role of the immune system in acute ischaemic stroke has prompted the search for immunomodulatory therapies. Pregnancy-specific glycoproteins (PSGs) are a group of proteins synthesised by placental trophoblasts which show immunomodulatory properties. The aim of this study was to determine whether a proposed PSG1-based therapeutic enhanced recovery in a mouse model of brain ischaemia and to explore possible immunomodulatory effects.
- Authors
Kyle Malone, Jennifer A. Shearer, John M. Williams, Anne C. Moore, Tom Moore, Christian Waeber.
- Year
- 2022
- Journal Name
- Brain, Behaviour and Immunity Health
- Category
- Journal Article
- Full Citation
Kyle Malone, Jennifer A. Shearer, John M. Williams, Anne C. Moore, Tom Moore, Christian Waeber. Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia. Brain, Behavior, & Immunity - Health,
Volume 25, 2022, 100497, ISSN 2666-3546.- Link to Publication
- https://www.sciencedirect.com/science/article/pii/S2666354622000874