Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling
Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital growth, survival and metabolic functions in the brain. Here we describe specific and significant alterations in IGF-1R, IR, and their key substrate adaptor proteins IRS-1 and IRS-2 in Alzheimer's disease (AD). Western immunoblot analysis detected increased IGF-1R levels, and decreased levels of IGF-1-binding protein-2 (IGFBP-2), a major IGF-1-binding protein, in AD temporal cortex. Increased IGF-1R was observed surrounding and within amyloid-β (Aβ)-containing plaques, also evident in an animal model of AD, and in astrocytes in AD.
- Authors
Aileen M. Moloney 1, Rebecca J. Griffin 1, Suzanne Timmons 1, Rosemary O’Connor 1, Rivka Ravid 2, Cora O’Neill 1
- Department of Biochemistry, BioSciences Institute, University College Cork, Cork, Ireland
- The Netherlands Brain Bank, Meibergdreef 33, 1105 AZ, Amsterdam ZO, The Netherlands
- Year
- 2010
- Journal Name
- Neurobiology of Aging
- Category
- Journal Article
- Full Citation
Aileen M. Moloney, Rebecca J. Griffin, Suzanne Timmons, Rosemary O’Connor, Rivka Ravid, Cora O’Neill. Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiology of Aging. 2010 Feb Vol 31, Issue 2, 224-243.
- Link to Publication
- https://www.sciencedirect.com/science/article/pii/S0197458008001176?via%3Dihub