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Catherine Keohane

Research Interests

Epidemiology and Molecular markers in  Gliomas

Malignant gliomas are the most malignant neoplasm of humans classically associated with a very prognosis. They are increasing in incidence, possibly due to an ageing population and increased survival from other diseases. Glioma behaviour and response to both radiation and chemotherapy is linked to  a number of molecular  markers, some of which can be reliably tested in formalin fixed paraffin embedded tissue, used routinely in brain tumour diagnosis.

Matched with clinical data from our CNS tumour database, this makes them very useful to assess both in archival and recent biopsies of brain tumours. 

Current Projects: CNS Tumours.

  1. Stability of MGMT over time in tissue from recurrent Gliomas  (with Dr W Stewart Glasgow University)
  2. New primary CNS Tumours in patients treated for a systemic malignancyTissue Assessment of a new target molecule for treatment of Malignant Gliomas (with  Dr Paul Mulholland, Institute of Neurology, London )

Invited Publicaions: Articles:

  1. A Review of Human Prison Diseases and the relationship of the new variant of Creutzfeldt Jakob Disease to Bovine Spongiform Encephalopathy. (Invited Review) Keohane C, Hospital Doctor of Ireland 1997 3:2;11-15
  2. New Variant CJD – an unfolding story. (Invited Review)  Keohane C. Forum,  (Journal of the Irish College of General Practitioners) 1998, 15, 3, 16-21.
  3. Creutzfeldt Jakob Disease with emphasis on the New Variant (Invited Review).  Keohane C.   An Bord Althranais News.  1998, 10, 2, 4-8.
  4. New Variant CJD – an update (Invited Review) Keohane C. Converse (Journal of the Academy of Medical Laboratory Science).  2000, 30, 5, 15-18.
  5. Pulvinar sign on MRI images in variant Creutzfeldt-Jakob disease.(Invited Editorial) Keohane C. Lancet.  2000 22;355 (9213):1384
  6. Some Aspects of Neuropathology in Central Nervous System Disease Diagnosis.(Invited Editorial) Keohane C.  Editorial Irish Medical Journal 2008, 101, 198-200.

Invited publications: Book Chapters

  1. Atlas of CNS Pathology in Aids.  Chapter 7 Central Nervous System Pathology in Paediatric Aids. Keohane C, Lacroix-Jousselin C, Dickson D. Oxford Press 1993.  P177 – 208.
  2. Report of the Bovine Spongiform Encephalopathy (BSE) Scientific Advisory Committee. July 1999.  ISBN – 1902277104.
  3. Golden JA, Harding BN, Pathology and Genetics. Developmental Neuropathology. ISN Neuropath Press, Basel 2004 Ch 43. Keohane C. Perinatal and Postnatal infections. P367-379.
  4. Kalimo H, Pathology and Genetics Cerebrovascular Diseases.  ISN Neuropath Press, Basel 2005, Chapter 20.  Bazille C, Keohane C, Gray F.  Systemic Diseases and Drug-Induced Vasculitis.  P151-162.
  5. Clinical Neuroscience Research in Ireland and the Role of the Irish Institute of Clinical Neurosciences. Keohane C. in The Future for Neurological Conditions in Ireland: A Challenge for Healthcare ;an Opportunity for Change. Chapter 7  p57-60. Neurological Alliance of Ireland Publication  2010.)

Papers in peer-Reviewed Journals

  1. Hydrops fetalis due to congenital cardiac rhabdomyoma. Soltan H,  Keohane C. Br. J. Obst.  Gyn 88,7, p   771-773.  1981.
  2. Chloroma of the mandible, a problem of diagnosis and management. Conran M, Keohane C, Kearney P.J. Acta Paediatrica Scandinavia 71, 1041-43   1982.
  3. Chondroblastoma of the skull. Feely M,  Keohane C. Journal of Neurology, Neurosurgery and Psychiatry 47 (12), 1348-50, 1984.
  4. Atypical Verner Morrison Syndrome.  Molloy W, Keohane, C,Whelton M.J.  Irish Medical Journal 78, 4, 100-101  1985.
  5. Prune Belly Syndrome with ultrasound demonstration of relief of megacystis in utero. Fitzsimons RB, Keohane C, Galvin J.  British Journal of Radiology 58, 374-6 1985.
  6. Subacute Spongiform Encephalopathy (Creutzfeldt Jakob Disease) with amyloid angiopathy.  Keohane C, Peatfield R, Duchen LW.  Journal of Neurology Neurosurgery and Psychiatry 48, 1175-8 1985.
  7. Extensive form of Progressive Multifocal Leucoencephalopathy associated with laryngeal carcinoma. Louarn F, Gray F, Gaston A, Gherardi R, Keohane C, Degos DJ.  Journal of Neurology 234, 107-11  1987.
  8. Determining safe margin of resection in low anterior resection for rectal cancer.  Kirwan WO, Drumm J, Hogan JM, Keohane C.  British Journal of Surgery 75, 720 1988.
  9. Pathology of the Central Nervous System in 40 case of Acquired Immunodeficiency Syndrome (AIDS). Gray F, Gherardi R, Keohane C,  Favolini M, Sobel A, Poirier J. Neuropathology and Applied Neurobiology 14 365-80 1988.
  10. The Meckel Syndrome in an Irish Population: A post-mortem study. Keohane C ,  Cullinane C,  Brett F. Irish Journal of Medical Science 157 12 385-7 1988.
  11. Intra-abdominal rupture of first trimester cervical pregnancy. Marcellus M,  Jenkins DM, Keohane C. Irish Journal of Medical Science 158, 1, 20-22 1989.
  12. Hyperthyroidism due to TSH secreting pituitary adenoma. (3 cases) Dunne F,  Feely M,  Ferris JB, Keohane C, Murphy D. Quarterly Journal of Medicine.  New Series 75, 276,  pp345-354.  1990.
  13. Cryptococcal granuloma of the brain Keohane C, Galvin RJ, Buckley TF. Journal of Neurology Neurosurgery and Psychiatry 1990 53 1107-1108.
  14. Paraganglioma of the Cauda Equina - a case report and review of the literature. O 'Sullivan M,  Keohane C,  Buckley TF. British Journal of Neurosurgery 1990, 4 - 63-8.
  15. Neuropathy due to podophyllin intoxication  O'Mahony S, Keohane C, Jacobs J, O Riordain J, Whelton MJ.  J. Neurol (1990).  237: 110-112.
  16. Acute fatal leukoencephalopathy after Interleukin-2 therapy.  Vecht CJ, Keohane C,  Menon R,  Henzen-Logmans SC,  Punt CJA, Stoter /G. The New England Journal of Medicine, (1990) 323, 16, 1146-7.
  17. Hurler's disease with diastematomyelia. Keohane C,  O'Leary J,  O Neill M,  Kearney PJ. Journal of Neuropathology and Applied Neurobiology (1991) 17 2 163-167.
  18. Cerebral Lymphoma and HIV encephalitis in a case of paediatric AIDS  Keohane C , Robain O,  Ponsot G,  Gray F. Irish Journal of Medical Science (1991) 160, 6, 179-182.
  19. Central Nervous System Pathology in Children with AIDS.  A review. Keohane C , Gray F. Irish Journal of Medical Science.  (1991) 160, 9, 277-281.
  20. Early brain changes in HIV infection:  neuropathological study of 11, HIV – 1 seropositive, non-AIDS cases.  Gray F, Lescs MC,  Keohane C,  Paraire F,  Marc B,  Durignon M, Gherardi R. Journal of Neuropathology and Experimental Neurology, (1992)  51,  177-185.
  21. Spinal cord infarction caused by cartilage embolus to the anterior spinal artery. Moorhouse D, Burke M, Keohane C, Farrell MJ.  Surgical Neurology.  37(6) 1992   448-52.
  22. Fatal Vertebral Giant Cell Arteritis.Sheehan M,  Keohane C,  Twomey C,  J. Clin. Path.  (1993)  46, 1129-31.
  23. Late Recurrence of Craniopharyngioma in the Cerebello-Pontine Angle. Keohane C, Hally M,  Ryder DQ,  Buckley  TF. Journal of Neurology  Neurosurgery Psychiatry.  1994  57,  7,  873-4.
  24. Bilateral abducens nerve lesions in unilateral type 3 Duanes retraction syndrome. Mulhern M, Keohane C, O Connor G, Br. J. Ophth.  1994,78, 7, 588-91.
  25. Familial Dementia with Pick's cells, a case report of probable familial Pick's Disease. Gaughran F, Keohane C,  Buckley M.  Irish Journal of Psychological Medicine.  1994, 11, 34-38.
  26. Unexpected  neurological deficits following recovery from anaesthesia. Porter J, Lynch L,  Hart S,  Keohane C. Canadian Journal of Anaesthesia.  1994 41,4,317-320.
  27. Gray F,  Belec L,  Keohane C, deTruchis P,  Clair B, Durigon M, Sobel A, Gherardi R. Zidovudine therapy and HIV encephalitis: a 10 year neuropathological survey. AIDS.  1994, 8, 489-493.
  28. Clinical characteristics  of a family with chromosome 17 linked disinhibition - dementia - parkinsonism - amyotrophy complex. Lynch T, Sano M, Marder KS,  Bell KL,  Foster NL,  Defendini R, Sima AAF, Keohane C, Nygaard TG,  Fahn S,  Mayeux R, Rowland LP, Wilhelmsen KC.  Neurology 1994, 44: 1878-84.
  29. Human Spongiform Encephalopathies, Prion Diseases. Keohane C.   Irish Doctor.   1994, 6, 5, 19-26.
  30. Les Maladies a prions chez l'homme. Keohane C. Archives d'Anatomie et de Cytologie Pathologiques.  1994, 42, 2, 69-75.
  31. A further view of the 12th International Congress of Neuropathology. Keohane C. Neuropathol.  Appl. Neurobiol  1995, 21, 143-144.
  32. Acute presentation of cystic adenomatoid malformation of lung in a 9 year old child.Spence L, Ahined S, Watson, JB, O'Neill M, Keohane C. Pediatr Radiology.1995 25: (7): 572-3. 
  33. Neuronal Apoptosis in HIV infection. Adle-Bassiette H,  Levy Y, Colombel M, Poron F, Natchev S, Keohane C, Gray F,  J. Neuropathol  Appl  Neurobiol.  1995,  21,  218-227.
  34. Calcific cardiomyopathy, an unusual cause of death. Burke L,  Keohane C,  Sheppard M,  Bredin CJ. Cardiovascular Pathobiology, Vol. 1 No-2, 81-84 (1996).
  35. The Neuropathology of  Chromosome 17-linked Dementia. Sima AAF,  Defendini RF,  Keohane C,  D'Amato C,  Foster NL, Lynch T, Wilhelmsen K. Annals of Neurology. 1996; 39:734-43.
  36. Herpes Simplex Virus Type I encephalitis in Acquired Immuodeficiency Syndrome Chretien F. Belec L., Hilton, D.A., Flament-Saillour M., Guioon F., Wimgertsmann L., Baudrimont M., DeTruchis P., Keohane C., Vital C., Love S., Gray F. Neuropathol.  Appl Neurobiol 1996;  22,5:394-404. 
  37. Creutzfeldt Jakob Disease (CJD) in Ireland; correlation of pathologically diagnosed cases with data from death certificates. Horan G, Farrell M, Keohane C.  Health Research Board  Report 1996.
  38. Motor Nerve Transplantation Gray WP, Keohane C, Kirwan WD.  J Neurosurg. 1997. 87:4, 615-24.
  39. The human prion diseases.  A review with special emphasis on new variant CJD and coments on surveillance. Keohane C.  Clin Exp Pathol. 1999; 47(3-4): 125-32. 
  40. Solitary intracranial myofibroma in a child.  O’Suilleabhain CB, Marks CJ, Ryder D, Keohane C, O’Sullivan MJ.   J Neurol Neurosurg Psychiatry.  1999 Aug; 67(2):253-4.  
  41. Localization of HIV-1 co receptors CCR5 and CXCR4 in the brain of children with AIDS. Vallat AV, De Girolami U, He J. Mhashilkar A, Marasco W, Shi B, Gray F, Bell J, Keohane C, Smith TW, Gabuzda D.  Am J Pathol.  1998; 152(1): 167-78.
  42. Clinical characteristics of a family with chromosome 17-linked disinhibition dementia parkinsonism amyotrophy complex. Lynch T, Sano M, Marder KS, Bell KL, Foster NL, Defendini RF, Sima AA, Keohane C, Nygaard TG, Fahn S, Mayeux R, Rowland LP, Wilhelmsen KC. Neurology 2001 57(10 suppl 3) S39-45.
  43. Effects of autologous platelet concentrate and serum on retinal wound healing in an animal model. Cullinane AB, O’Callaghan P, McDermott K, Keohane C, Cleary PE.  Graefes. Arch Clin Exp Ophthalmol.  2002;240 (1):35-41.
  44. Hereditary Cerebral Amyloid Angiopathies. Gray F, Keohane C. Revue Neurologique (Paris) 2001; 157(10):1207-17.
  45. Neuropathology and neurodegeneration in human immunodeficiency virus infection. Pathogenesis of HIV-1 induced lesions of the brain, correlation with HIV associated disorders and modifications according to treatments.  Gray F, AdleBiassette H, Chretien F, Lorin de la Grandmaison G, Force G, Keohane C. Clinical Neuropathology 2001: 20(4) 146-55.
  46. The Neuropathology of HIV infection in the era of Highly Active Antiretrovial Therapy (HAART) Gray F, Keohane C. Brain Pathology 2003; 13(1): 79-83.
  47. Creutzfeldt – Jakob Disease in Ireland: Epidemiological Aspects 1980-2002. Horan G, Keohane C, Molloy S, Howley R, Harney M, Heffernan J, McGuigan C, Hutchinson M, Brett F, Farrell M. Eur Neurol. 2004;51(3):138-7.
  48. Topacheous gout as a rare cause of spinal stenosis in the lumbar region report. Kelly J, Lim C, Kamel M, Keohane C, O’Sullivan M.  J Neurosurg Spine.  2005; 2(2):215-7.
  49. Massive retroperitoneal ganglioneuroma presenting with small bowel obstruction 18 years following initial diagnosis. Cronin EMP, Coffey JC, Herlihy D, Romics L, Aftab F, Keohane C, Redmond HP.  Irish J. Med SC. 2005 174(2) 58-61.
  50. Intracranial metastasis from a sacrococcygeal chordoma.  Case report.  Kamel MH, Lim C, Kelleher M, Aquilina K, Keohane C, Kaar GF.  J Neurosurgery: 2005; 102(4):730-2.
  51. Epithelioid Haemangioendothelioma of the spine. Report of two cases. Aquilina K, Lim C, Kamel M, Marks C, O’Sullivan MG, Keohane C. J Neurosurg Spine 2005; 3: 393-399
  52. Pseudoaneurysm of the occipital artery an ususual cause of persisting headache after minor head injury.  Aquilina K, Carty F, Keohane C, Kaar GF. Ir Med J 2005 98(7); 215-217.
  53. Intramedullary Capillary haemangioma. Kelleher T, Aqulina K, Keohane C, O’Sullivan MG Br J Neurosurg. 2005 Aug; 19(4):345-8
  54. Granular cell tumour of the neurohypophysis, a rare sellar tumour with specific radiological and operative features. Aquilina K, Kamel M, Kalimuthu SG, Marks JC, Keohane C. Br J Neurosurgery. 2006 Feb; 20(1):51-4
  55. Atypical presentation of macrophagic myofasciitis 10 years post vaccination.  Ryan AM, Bermingham N, Harrington HJ, Keohane C. Neuromuscul Disord. 2006 Dec;16(12):867-9. 
  56. Spina S, Murell JR, Yoshida H, Ghetti B, Bermingham N, Sweeney B, Dlouhy SR, Crowther RA, Goedert M, Keohane C. The novel Tau mutation G335S:clinical, neuropathological and molecular characterization.  Acta Neuropathol (Berl). 2007 Apr;113(4):461-70.
  57. Oittinen HA, O’Shaughnessy M, Cullinane AB, Keohane C. Malignant melanoma of the ciliary body presenting as extraocular metastasis in the temporalis muscle. J Clin Pathol. 2007 Jul;60(7):834-5.
  58. Kamel MH, Kelleher M, O’Riordan C, Keohane C, O’Sullivan M.  CT and MRI ‘ring sign’ may be due to demyelination: diagnostic pitfall.   Br J Neurourg 2007 Jun;21(3):309-11.
  59. Bermingham N, Townley D, Fenton S, Keohane C. Ocular Langerhans cell histiocytosis.  EYE 2007 21 (8):1127-8
  60. In vivo and post mortem clinicoannatomical correlations in FTDP-17 B. Ghetti, S. Spina, JR. Murrell, ED. Huey, P. Pietrini, B. Sweeney, EM. Wasserman, C. Keohane, M. Geodert, MR. Farlow, J. Grafman. Neurodegener  Dis. 2008; 5 (3-4), 215-7.
  61. Extraskeletal Myxoid Chondrosarcoma of the cerebellopontine angle presenting during pregnancy  O’Brien J, Thornton J, Cawley D, Farrell M, Keohane K, Kaar G, McEvoy L, O’Brien DF.   Br J Neurosurg 2008; 22(3): 429-32
  62. Transitional cell carcinoma of the upper ureter metastatic to the thoracic spine presenting as a spinal cord compression. Larkin JO, Cullen IM, Kelleher MO, Fitzgibbon J, Keohane K, O’Sullivan MG, Rogers E.  Scientific World Journal 2008; 25; 8: 223-7.
  63. The Immunohistochemical demonstration of Helicobacter Pylori in rectal ectopia.  M. Corrigan, CJ Sheilds, C. Keohane, WO. Kirwan. Surg Laparosc, Endosc Percutan Tech 2009; 19(4):146-8 
  64. Neuronal phosphorylated RNA-dependant protein kinase in Creutzfeldt-Jakob disease Paquet C, Bose A, Polivka M, Poech’k K, Brouland JP, Keohane C, Hugon J, Gray F.J Neuropathol Exp Neurol.  2009; 68(2):190-8 
  65. Bilateral brachial neuropathy and acute aortic dissection due to giant cell arteritis. S Saidha, TH Mok, M Butler, C Keohane, H Harrington. J Neurol.  2009;256(8):1346-8 
  66. The role of biopsy in the diagnosis of infections of the central nervous system:  A review of 5 years in Cork University Hospital. M Jansen, D. Corcoran, N. Bermingham, C. Keohane. Irish Medical Journal 2010; 103(1):6-8
  67. Metastatic Meningioma / PET / CT imaging findings C. Brennan, K. O’Regan, C. Keohane, J. Hinchion, B. Sweeney, M. Maher.  Br J Radiol . 2010 Dec;83(996):e259-62.
  68. Determinants of outcome for patients undergoing lumbar discectomy: A pilot study O Hickey, S Burke, PHafeez, A Mudrakouski, I DHayes, C Keohane , M Butler,GD Shorten.Eur J Anaesthesiol 2010;27:696-701 
  69. Eccrine Syringofibroadenoma of the Eyelid in association with an eye prosthesis  M Guerin, T Droney, C Keohane, S Fenton. In Press :Eye Polyarteritis nodosa presenting with clinical and radiological features of polymyositis: M Haroon,  N Bermingham, C Keohane, S Harney. In press: Clinical Rheumatology.

     

Dr Catherine Keohane

Dr Catherine Keohane is a Consultant Neuropathologist in Cork University Hospital. Her research interests include Epidemiology and Molecular markers in  Gliomas.

Cork NeuroScience CNS Centre - Integrating Clinical and Basic Research

Cork NeuroScien floor,

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