2020 Publications

1. Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System

Buckley, M. M., O’Brien, R., Brosnan, E., Ross, R. P., Stanton, C., Buckley, J. M., et al. (2020). Glucagon-like peptide-1 secreting L-cells coupled to sensory nerves translate microbial signals to the host rat nervous system. Frontiers in Cellular Neuroscience

2. Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects

Sartawi, Z., Waeber, C., Schipani, E., & Ryan, K. B. (2020). Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects. International Journal of Pharmaceutics, 590, 119956-119956

3. A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy

Chen, J., Wang, X., Chen, L., Tang, J., Xia, Y., Qian, K., Qin, Z., Waeber, C., & Sheng, R. (2020). A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy. Neuropharmacology, 181, 108326-108326.

4. Development of Dynamic Cell and Organotypic Skin Models, for the Investigation of a Novel Viscoelastic Burns Treatment Using Molecular and Cellular Approaches.

Wallace, R. G., Kenealy, M., Brady, A. J., Twomey, L., Duffy, E., Degryse, B., Caballero-Lima, D., Moyna, N. M., Custaud, M., Meade-Murphy, G., Morrin, A., & Murphy, R. P. (2020). Development of dynamic cell and organotypic skin models, for the investigation of a novel visco-elastic burns treatment using molecular and cellular approaches. Burns, 46(7), 1585-1602

5.Rapid fragmentation of microplastics by the freshwater amphipod Gammarus duebeni (Lillj.)

Mateos-Cárdenas, A., O’Halloran, J., van Pelt, Frank N. A. M., & Jansen, M. A. K. (2020). Rapid fragmentation of microplastics by the freshwater amphipod gammarus duebeni (lillj.). Scientific Reports, 10(1), 12799-12799.

6. 'Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?'

McElwain, C. J., Tuboly, E., McCarthy, F. P., & McCarthy, C. M. (2020). Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: Windows into future cardiometabolic health? Frontiers in Endocrinology (Lausanne), 11, 655-655.

7.microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression'

Fitzsimons, S., Oggero, S., Bruen, R., McCarthy, C., Strowitzki, M. J., Mahon, N. G., Ryan, N., Brennan, E. P., Barry, M., Perretti, M., & Belton, O. (2020). microRNA-155 is decreased during atherosclerosis regression and is increased in urinary extracellular vesicles during atherosclerosis progression. Frontiers in Immunology, 11, 576516-576516

8. Development of Dynamic Cell and Organotypic Skin Models, for the Investigation of a Novel Viscoelastic Burns Treatment Using Molecular and Cellular Approaches.

Wallace, R. G., Kenealy, M., Brady, A. J., Twomey, L., Duffy, E., Degryse, B., Caballero-Lima, D., Moyna, N. M., Custaud, M., Meade-Murphy, G., Morrin, A., & Murphy, R. P. (2020). Development of dynamic cell and organotypic skin models, for the investigation of a novel visco-elastic burns treatment using molecular and cellular approaches. Burns, 46(7), 1585-1602

9. Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator.

McElwain, C., & McCarthy, C. M. (2020). Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator. European Journal of Obstetrics & Gynecology and Reproductive Biology, 251, 60-65.

10. Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19.

Walther, T., & Kuebler, W. M. (2020). Don’t judge too RAShly: The multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19. American Journal of Physiology. Lung Cellular and Molecular Physiology, 318(5), L1023-L1024.

11. Short-term Western Diet aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Cremonese, C., Schierwagen, R., Uschner, F. E., Torres, S., Tyc, O., Ortiz, C., Schulz, M., Queck, A., Kristiansen, G., Bader, M., Sauerbruch, T., Weiskirchen, R., Walther, T., Trebicka, J., & Klein, S. (2020). Short-term western diet aggravates non-alcoholic fatty liver disease (NAFLD) with portal hypertension in TGR(mREN2)27 rats. International Journal of Molecular Sciences, 21(9), 3308

12. The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30

Schwiebs, A., Wang, Y., Moore, A. M., Zhu, X., Pankow, K., Siems, W., & Walther, T. (2020). The virtually mature B‐type natriuretic peptide (BNP1‐32) is a precursor for the more effective BNP1‐30. British Journal of Pharmacology, 177(6), 1424-1433.

13. Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.

Kaya, E., Smith, D. A., Smith, C., Boland, B., Strupp, M., & Platt, F. M. (2020). Beneficial effects of acetyl-DL-leucine (ADLL) in a mouse model of sandhoff disease. Journal of Clinical Medicine, 9(4), 1050

14. Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.

Morillon, A., Williamson, R. D., Baker, P. N., Kell, D. B., Kenny, L. C., English, J. A., McCarthy, F. P., & McCarthy, C. (2020). Effect of L-ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia. PloS One, 15(3), e0230977-e0230977.

15. The effect of sphingosine‐1‐phosphate on the endothelial glycocalyx during ischemia‐reperfusion injury in the isolated rat heart.

Araibi, H., van der Merwe, E., Gwanyanya, A., & Kelly-Laubscher, R. (2020). The effect of sphingosine‐1‐phosphate on the endothelial glycocalyx during ischemia‐reperfusion injury in the isolated rat heart

16. The Biology of Ergothioneine, an antioxidant nutraceutical.

Borodina, I., Kenny, L. C., McCarthy, C. M., Paramasivan, K., Pretorius, E., Roberts, T. J., van der Hoek, Steven A, & Kell, D. B. (2020). The biology of ergothioneine, an antioxidant nutraceutical. Nutrition Research Reviews, 33(2), 190-217.

17. The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2

Anoopkumar-Dukie, S., Conere, T., Houston, A., King, L., Christie, D., McDermott, C., & Allshire, A. (2020). The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2. Prostaglandins & Other Lipid Mediators, 148, 106422-106422.

18. L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model.

Williamson, R. D., McCarthy, F. P., Manna, S., Groarke, E., Kell, D. B., Kenny, L. C., & McCarthy, C. M. (2020). L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model. Hypertension, 75(2), 561–568.

19. Short-Term Western Diet Aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Cremonese, C., Schierwagen, R., Uschner, F. E., Torres, S., Tyc, O., Ortiz, C., Schulz, M., Queck, A., Kristiansen, G., Bader, M., Sauerbruch, T., Weiskirchen, R., Walther, T., Trebicka, J., & Klein, S. (2020). Short-term western diet aggravates non-alcoholic fatty liver disease (NAFLD) with portal hypertension in TGR(mREN2)27 rats. International

20. Acetyl-leucine slows disease progression in lysosomal storage disorders

Kaya, E., Smith, D. A., Smith, C., Morris, L., Bremova-Ertl, T., Cortina-Borja, M., Fineran, P., Morten, K. J., Poulton, J., Boland, B., Spencer, J., Strupp, M., & Platt, F. M. (2020). Acetyl-leucine slows disease progression in lysosomal storage disorders. Brain communications, 3(1), fcaa148. Journal of Molecular Sciences, 21(9), 3308

21. Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

Morais, L. H., Golubeva, A. V., Moloney, G. M., Moya-Pérez, A., Ventura-Silva, A. P., Arboleya, S., Bastiaanssen, T., O'Sullivan, O., Rea, K., Borre, Y., Scott, K. A., Patterson, E., Cherry, P., Stilling, R., Hoban, A. E., El Aidy, S., Sequeira, A. M., Beers, S., Moloney, R. D., Renes, I. B., … Cryan, J. F. (2020). Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse. Current biology : CB, 30(19), 3761–3774.e6.

22. The virtually mature B‐type natriuretic peptide (BNP1‐32) is a precursor for the more effective BNP1‐30

23. Lasting Impact of Chronic Adolescent Stress and Glucocorticoid Receptor Selective Modulation in Male and Female Rats

Cotella, Evelin M. Moloney , R. et al. “Lasting Impact of Chronic Adolescent Stress and Glucocorticoid Receptor Selective Modulation in Male and Female Rats.” Psychoneuroendocrinology vol. 112 (2020): 104490.

24. Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse

Morais, Livia H. Moloney, R. et al. “Enduring Behavioral Effects Induced by Birth by Caesarean Section in the Mouse.” Current biology : CB vol. 30,19 (2020): 3761-3774.e6.

25. Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice

Nawreen, Nawshaba. Moloney, R et al. “Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABAergic Parvalbumin Interneurons Attenuates the Impact of Chronic Stress in Male Mice.” eNeuro vol. 7,5 ENEURO.0423-19.2020. 28 Oct. 2020

Department of Pharmacology and Therapeutics

Cógaseolaíocht agus Teiripic

Room 2.36B, 2nd floor floor, T12XF62