Publications
We aim to share information about our work within Future Ageing & Brain Science, in lots of different ways – browse our publications in this section.
Where possible, we make the full texts of our publications openly available. If you are unable to access the full texts of any of our publications, please contact us and we will send them to you.
| Category | Category | Keywords | Year | Title | Abstract | Actions |
|---|---|---|---|---|---|---|
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Journal Article |
Journal Article | 2025 |
Factors influencing the effectiveness of nature-based interventions (NBIs) aimed at improving mental health and wellbeing: An umbrella review |
everal systematic reviews support nature-based interventions (NBIs) as a mechanism of enhancing mental health and wellbeing. However, the available evidence for the effectiveness of these interventions is fragmentary and mixed. The heterogeneity of existing evidence and significant fragmentation of knowledge within the field make it difficult to draw firm conclusions regarding the effectiveness of NBIs. | More details Read publication | |
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Journal Article |
Journal Article | 2023 |
The impact of fingolimod on Treg function in brain ischaemia |
Fingolimod has generally shown neuroprotective effects in stroke models. Here, we tested the hypothesis that fingolimod modulates T-cell cytokine production towards a regulatory phenotype. Second, we investigated how fingolimod altered the Treg suppressive function and the sensitivity of effector T cells to regulation. | More details Read publication | |
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Journal Article |
Journal Article | 2025 |
Unmasking Nuances Affecting Loneliness: Using Digital Behavioural Markers to Understand Social and Emotional Loneliness in College Students |
Loneliness is a global issue which is particularly prevalent among college students, where it poses risks to mental health and academic success. Chronic loneliness can manifest in two primary forms: social loneliness, which is defined by a lack of belonging or a social network, and emotional loneliness, which comes from the absence of deep, meaningful connections. Differentiating between these forms is crucial for designing personalized and targeted interventions. Passive sensing technology offers a promising, unobtrusive approach to detecting loneliness by using behavioural data collected from smartphones and wearables. | More details Read publication | |
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Journal Article |
Journal Article | 2025 |
Behavioral assessment of neuropsychiatric outcomes in rodent stroke models |
Stroke-associated mood disorders are less recognised than sensorimotor impairment, despite their high prevalence. Similarly, few experimental stroke studies assess non-sensorimotor functions. This study examined the prevalence and implementation of non-sensorimotor tests in three stroke-focused journals over the last twenty years. | More details Read publication | |
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Journal Article |
Journal Article | 2025 |
General Practitioners’ Views on Mental Health Following Stroke: Findings from a Cross-Sectional Study |
Post-stroke mood changes currently affect a significant proportion of stroke survivors and are seldom recognised or treated in clinical practice. As general practitioners (GPs) typically know their patients well and see them regularly, they may be well-positioned to identify these mood changes. | More details Read publication | |
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Journal Article |
Journal Article | 2025 |
Prescribing Cascades Among Older Community-Dwelling Adults: Application of Prescription Sequence Symmetry Analysis to a National Database in Ireland |
Prescribing cascades occur when one medication is used to treat adverse effects of another medication. Older adults with polypharmacy are at higher risk for this phenomenon. We examined the prevalence, magnitude, and effect modification of 9 prescribing cascades (ThinkCascades) among older community-dwelling adults in a national prescription database. | More details Read publication | |
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Journal Article |
Journal Article | 2025 |
Psychological factors associated with sensory processing sensitivity in caregiving contexts: A protocol for a systematic review and meta-analysis |
Given the stressful nature of both professional and informal caring environments, it is of interest to examine the experience of HSPs, those who score highly in SPS, within caregiving roles. The research examining SPS’ psychological correlates in caregivers has yet to be synthesised. The current study aims to systematically review the psychological correlates of SPS in caregiving populations and, where possible, to test the strength of these associations through meta-analysis. | More details Read publication | |
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Journal Article |
Journal Article | 2024 |
Barriers and facilitators to implementing workplace interventions to promote mental health: qualitative evidence synthesis |
The objectives of this review are to establish the scope of research with explicit analysis of implementation aspects of workplace mental health interventions and to identify barriers and facilitators to implementation in general and within SMEs and selected sectors. | More details Read publication | |
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Journal Article |
Journal Article | 2024 |
The effects of different types of organisational workplace mental health interventions on mental health and wellbeing in healthcare workers: a systematic review |
To determine if and which types of organisational interventions conducted in small and medium size enterprises (SMEs) in healthcare are effective on mental health and wellbeing. | More details Read publication | |
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Journal Article |
Journal Article | 2024 |
The association between sensory processing and stress in the adult population: A systematic review |
There is emerging empirical evidence indicating that differences in self-reported sensory processing may be associated with differences in levels of stress in the adult populations. Understanding how sensory processing relates to stress is of clinical relevance, given the well-established impact of stress on physical health, mental health and well-being. Although several studies have examined the association between sensory processing and stress in adult populations, no published reviews have systematically summarised and synthesised these findings. We aimed to fill this gap by conducting a systematic review to synthesise the available evidence examining the association between self-reported sensory processing and self-reported measures of stress in the adult population. | More details Read publication | |
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Journal Article |
Journal Article | 2023 |
Adverse drug reactions and associated patient characteristics in older community-dwelling adults: a 6-year prospective cohort study |
To date, research on adverse drug reactions (ADRs) has focused on secondary care, and there is a paucity of studies that have prospectively examined ADRs affecting older adults in general practice. This prospective cohort study of ADRs in general practice shows that over one-quarter of older adults experienced an ADR over a 6-year period. Polypharmacy is independently associated with ADR risk in general practice and older adults on ≥10 drug classes should be prioritised for regular medication review. | More details Read publication | |
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Journal Article |
Journal Article | 2022 |
Recombinant pregnancy-specific glycoprotein-1-Fc reduces functional deficit in a mouse model of permanent brain ischaemia |
The well-characterised role of the immune system in acute ischaemic stroke has prompted the search for immunomodulatory therapies. Pregnancy-specific glycoproteins (PSGs) are a group of proteins synthesised by placental trophoblasts which show immunomodulatory properties. The aim of this study was to determine whether a proposed PSG1-based therapeutic enhanced recovery in a mouse model of brain ischaemia and to explore possible immunomodulatory effects. | More details Read publication | |
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Journal Article |
Journal Article | 2019 |
Accuracy of consumer-level and research-grade activity trackers in ambulatory settings in older adults |
Wrist-worn activity trackers have experienced a tremendous growth lately and studies on the accuracy of mainstream trackers used by older adults are needed. This study explores the performance of six trackers (Fitbit Charge2, Garmin VivoSmart HR+, Philips Health Watch, Withings Pulse Ox, ActiGraph GT9X-BT, Omron HJ-72OITC) for estimating: steps, travelled distance, and heart-rate measurements for a cohort of older adults. | More details Read publication | |
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Journal Article |
Journal Article | 2019 |
Validity Evaluation of the Fitbit Charge2 and the Garmin vivosmart HR+ in Free-Living Environments in an Older Adult Cohort |
This study explored the performance of two wrist-worn trackers (Fitbit Charge 2 and Garmin vivosmart HR+) in estimating steps, energy expenditure, moderate-to-vigorous physical activity (MVPA) levels, and sleep parameters (total sleep time [TST] and wake after sleep onset [WASO]) against gold-standard technologies in a cohort of healthy older adults in a free-living environment. | More details Read publication | |
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Journal Article |
Journal Article | 2019 |
Potentially modifiable determinants of malnutrition in older adults: A systematic review |
Potentially modifiable determinants of malnutrition in older adults: A systematic review. | More details Read publication | |
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Journal Article |
Journal Article | 2013 |
Delirium in an adult acute hospital population: predictors, prevalence and detection |
To date, delirium prevalence and incidence in acute hospitals has been estimated from pooled findings of studies performed in distinct patient populations. | More details Read publication | |
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Journal Article |
Journal Article | 2012 |
Comparison of the quick mild cognitive impairment (Qmci) screen and the SMMSE in screening for mild cognitive impairment |
Differentiating mild cognitive impairment (MCI) from normal cognition (NC) is difficult. The AB Cognitive Screen (ABCS) 135, sensitive in differentiating MCI from dementia, was modified to improve sensitivity and specificity, producing the quick mild cognitive impairment (Qmci) screen. This study compared the sensitivity and specificity of the Qmci with the Standardised MMSE and ABCS 135, to differentiate NC, MCI and dementia. | More details Read publication | |
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Journal Article |
Journal Article | 2010 |
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling |
Insulin like growth factor-1 receptor (IGF-1R) and insulin receptor (IR) signalling control vital growth, survival and metabolic functions in the brain. Here we describe specific and significant alterations in IGF-1R, IR, and their key substrate adaptor proteins IRS-1 and IRS-2 in Alzheimer's disease (AD). Western immunoblot analysis detected increased IGF-1R levels, and decreased levels of IGF-1-binding protein-2 (IGFBP-2), a major IGF-1-binding protein, in AD temporal cortex. Increased IGF-1R was observed surrounding and within amyloid-β (Aβ)-containing plaques, also evident in an animal model of AD, and in astrocytes in AD. | More details Read publication |