Artificial intelligence-assisted left ventricular global longitudinal strain assessment in patients with acute myocardial infarction: a RESUS-AMI trial sub-analysis.

Mekonnen D, Spitzer E, McFadden EP, Caplice NM, Ren CB.Int J Cardiovasc Imaging. 2025 Jun;41(6):1225-1236. doi: 10.1007/s10554-025-03409-7. Epub 2025 Apr 29.PMID: 40301202 Clinical Trial.

 

Targeting the Gut-Heart Axis Improves Cardiac Remodeling in a Clinical Scale Model of Cardiometabolic Syndrome.

Herisson FM, Cluzel GL, Llopis-Grimalt MA, O'Donovan AN, Koc F, Karnik K, Laurie I, Canene-Adams K, Ross RP, Stanton C, Caplice NM.JACC Basic Transl Sci. 2024 Nov 20;10(1):1-15. doi: 10.1016/j.jacbts.2024.09.004. eCollection 2025 Jan.PMID: 39906593 Free PMC article.

 

Microbial bile salt hydrolase activity influences gene expression profiles and gastrointestinal maturation in infant mice.

Núñez-Sánchez MA, Herisson FM, Keane JM, García-González N, Rossini V, Pinhiero J, Daly J, Bustamante-Garrido M, Hueston CM, Patel S, Canela N, Herrero P, Claesson MJ, Melgar S, Nally K, Caplice NM, Gahan CGM.Gut Microbes. 2022 Jan-Dec;14(1):2149023. doi: 10.1080/19490976.2022.2149023.PMID: 36420990 Free PMC article.

 

Metabolomic Workflow for the Accurate and High-Throughput Exploration of the Pathways of Tryptophan, Tyrosine, Phenylalanine, and Branched-Chain Amino Acids in Human Biofluids.

Anesi A, Berding K, Clarke G, Stanton C, Cryan JF, Caplice N, Ross RP, Doolan A, Vrhovsek U, Mattivi F.J Proteome Res. 2022 May 6;21(5):1262-1275. doi: 10.1021/acs.jproteome.1c00946. Epub 2022 Apr 5.PMID: 35380444 Free PMC article.

 

High-fidelity porcine models of metabolic syndrome: a contemporary synthesis.

Cluzel GL, Ryan PM, Herisson FM, Caplice NM.Am J Physiol Endocrinol Metab. 2022 Apr 1;322(4):E366-E381. doi: 10.1152/ajpendo.00413.2021. Epub 2022 Feb 28.PMID: 35224983 Free article. Review.

 

Exploring the Gut Microbiota and Cardiovascular Disease.

Murphy K, O'Donovan AN, Caplice NM, Ross RP, Stanton C.Metabolites. 2021 Jul 29;11(8):493. doi: 10.3390/metabo11080493.PMID: 34436434 Free PMC article. Review.

 

A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation.

Cullen PP, Tsui SS, Caplice NM, Hinchion JA.Interact Cardiovasc Thorac Surg. 2021 May 10;32(5):683-694. doi: 10.1093/icvts/ivaa333.PMID: 33971665 Free PMC article. Review.

 

Obesity and COVID-19: A Virchow's Triad for the 21st Century.

Vaughan CJ, Cronin H, Ryan PM, Caplice NM.Thromb Haemost. 2020 Nov;120(11):1590-1593. doi: 10.1055/s-0040-1714216. Epub 2020 Jul 17.PMID: 32679596 No abstract available.

 

COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response.

Ryan PM, Caplice N.Open Heart. 2020 Jun;7(1):e001302. doi: 10.1136/openhrt-2020-001302.PMID: 32532804 Free PMC article. Review. No abstract available.

 

Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation.

Chen SG, Ugwu F, Li WC, Caplice NM, Petcu E, Yip SP, Huang CL.Tissue Eng Part B Rev. 2021 Feb;27(1):14-28. doi: 10.1089/ten.TEB.2019.0264. Epub 2020 Jul 27.PMID: 32503391 Review.

COVID-19-Where Have All the STEMIs Gone?

Tanner R, MacDaragh Ryan P, Caplice NM.Can J Cardiol. 2020 Jul;36(7):1161.e9-1161.e10. doi: 10.1016/j.cjca.2020.04.032. Epub 2020 May 1.PMID: 32371004 Free PMC article. No abstract available.

 

Is Adipose Tissue a Reservoir for Viral Spread, Immune Activation, and Cytokine Amplification in Coronavirus Disease 2019?

Ryan PM, Caplice NM.Obesity (Silver Spring). 2020 Jul;28(7):1191-1194. doi: 10.1002/oby.22843. Epub 2020 May 31.PMID: 32314868 Free PMC article. Review.

 

Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing.

Whelan DS, Caplice NM, Clover AJP.Sci Rep. 2020 Feb 14;10(1):2642. doi: 10.1038/s41598-020-59174-1.PMID: 32060374 Free PMC article.

 

 

 

 

Gut microbiome of a porcine model of metabolic syndrome and HF-pEF.

O'Donovan AN, Herisson FM, Fouhy F, Ryan PM, Whelan D, Johnson CN, Cluzel G, Ross RP, Stanton C, Caplice NM.Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H590-H603. doi: 10.1152/ajpheart.00512.2019. Epub 2020 Feb 7.PMID: 32031871 Free article.

 

Lactobacillus mucosae DPC 6426 as a bile-modifying and immunomodulatory microbe.

Ryan PM, Stolte EH, London LEE, Wells JM, Long SL, Joyce SA, Gahan CGM, Fitzgerald GF, Ross RP, Caplice NM, Stanton C.BMC Microbiol. 2019 Feb 8;19(1):33. doi: 10.1186/s12866-019-1403-0.PMID: 30736731 Free PMC article.

 

Randomized placebo controlled trial evaluating the safety and efficacy of single low-dose intracoronary insulin-like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS-AMI).

Caplice NM, DeVoe MC, Choi J, Dahly D, Murphy T, Spitzer E, Van Geuns R, Maher MM, Tuite D, Kerins DM, Ali MT, Kalyar I, Fahy EF, Khider W, Kelly P, Kearney PP, Curtin RJ, O'Shea C, Vaughan CJ, Eustace JA, McFadden EP.Am Heart J. 2018 Jun;200:110-117. doi: 10.1016/j.ahj.2018.03.018. Epub 2018 Apr 3.PMID: 29898838 Clinical Trial.

 

Bile acids at the cross-roads of gut microbiome-host cardiometabolic interactions.

Ryan PM, Stanton C, Caplice NM.Diabetol Metab Syndr. 2017 Dec 28;9:102. doi: 10.1186/s13098-017-0299-9. eCollection 2017.PMID: 29299069 Free PMC article. Review.

 

Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E^-/- mice.

Ryan PM, London LE, Bjorndahl TC, Mandal R, Murphy K, Fitzgerald GF, Shanahan F, Ross RP, Wishart DS, Caplice NM, Stanton C.Microbiome. 2017 Mar 13;5(1):30. doi: 10.1186/s40168-017-0246-x.PMID: 28285599 Free PMC article.

 

Selective M2 Macrophage Depletion Leads to Prolonged Inflammation in Surgical Wounds.

Klinkert K, Whelan D, Clover AJP, Leblond AL, Kumar AHS, Caplice NM.Eur Surg Res. 2017;58(3-4):109-120. doi: 10.1159/000451078. Epub 2017 Jan 6.PMID: 28056458

 

 

 

 

A Novel Selectable Islet 1 Positive Progenitor Cell Reprogrammed to Expandable and Functional Smooth Muscle Cells.

Turner EC, Huang CL, Sawhney N, Govindarajan K, Clover AJ, Martin K, Browne TC, Whelan D, Kumar AH, Mackrill JJ, Wang S, Schmeckpeper J, Stocca A, Pierce WG, Leblond AL, Cai L, O'Sullivan DM, Buneker CK, Choi J, MacSharry J, Ikeda Y, Russell SJ, Caplice NM.Stem Cells. 2016 May;34(5):1354-68. doi: 10.1002/stem.2319. Epub 2016 Mar 28.PMID: 26840832

 

Candida albicans exhibits enhanced alkaline and temperature induction of Efg1-regulated transcripts relative to Candida dubliniensis.

Caplice N, Moran GP.Genom Data. 2015 Sep 7;6:130-5. doi: 10.1016/j.gdata.2015.08.026. eCollection 2015 Dec.PMID: 26697354 Free PMC article.

 

Allogeneic MSC persistence may not be necessary for a beneficial effect in burn wound healing.

Whelan D, Caplice NM, Clover AJP.Burns. 2017 Feb;43(1):247-248. doi: 10.1016/j.burns.2015.08.021. Epub 2015 Nov 21.PMID: 26611503 No abstract available.

 

Systemic and Cardiac Depletion of M2 Macrophage through CSF-1R Signaling Inhibition Alters Cardiac Function Post Myocardial Infarction.

Leblond AL, Klinkert K, Martin K, Turner EC, Kumar AH, Browne T, Caplice NM.PLoS One. 2015 Sep 25;10(9):e0137515. doi: 10.1371/journal.pone.0137515. eCollection 2015.PMID: 26407006 Free PMC article.

 

Functional food addressing heart health: do we have to target the gut microbiota?

Ryan PM, Ross RP, Fitzgerald GF, Caplice NM, Stanton C.Curr Opin Clin Nutr Metab Care. 2015 Nov;18(6):566-71. doi: 10.1097/MCO.0000000000000224.PMID: 26406391 Review.

 

A novel CX3CR1 antagonist eluting stent reduces stenosis by targeting inflammation.

Ali MT, Martin K, Kumar AH, Cavallin E, Pierrou S, Gleeson BM, McPheat WL, Turner EC, Huang CL, Khider W, Vaughan C, Caplice NM.Biomaterials. 2015 Nov;69:22-9. doi: 10.1016/j.biomaterials.2015.07.059. Epub 2015 Aug 3.PMID: 26275859

 

Acute STEMI in the setting of a single coronary artery anomaly.

McCarthy C, Khider W, Caplice N.BMJ Case Rep. 2015 May 13;2015:bcr2015210002. doi: 10.1136/bcr-2015-210002.PMID: 25972382 Free PMC article.

 

Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy.

Gleeson BM, Martin K, Ali MT, Kumar AH, Pillai MG, Kumar SP, O'Sullivan JF, Whelan D, Stocca A, Khider W, Barry FP, O'Brien T, Caplice NM.Stem Cells. 2015 Sep;33(9):2726-37. doi: 10.1002/stem.2050. Epub 2015 Jun 4.PMID: 25969127

 

Genome Sequence of the Heteropolysaccharide-Producing Strain Lactobacillus mucosae DPC 6426.

Ryan PM, Guinane CM, London LE, Kelleher PR, Fitzgerald GF, Caplice NM, Ross RP, Stanton C.Genome Announc. 2015 Jan 15;3(1):e01350-14. doi: 10.1128/genomeA.01350-14.PMID: 25593248 Free PMC article.

 

Synthetic chemically modified mrna-based delivery of cytoprotective factor promotes early cardiomyocyte survival post-acute myocardial infarction.

Huang CL, Leblond AL, Turner EC, Kumar AH, Martin K, Whelan D, O'Sullivan DM, Caplice NM.Mol Pharm. 2015 Mar 2;12(3):991-6. doi: 10.1021/mp5006239. Epub 2015 Jan 27.PMID: 25588055

 

Sugar-coated: exopolysaccharide producing lactic acid bacteria for food and human health applications.

Ryan PM, Ross RP, Fitzgerald GF, Caplice NM, Stanton C.Food Funct. 2015 Mar;6(3):679-93. doi: 10.1039/c4fo00529e.PMID: 25580594 Review.

 

Exopolysaccharide-producing probiotic Lactobacilli reduce serum cholesterol and modify enteric microbiota in ApoE-deficient mice.

London LE, Kumar AH, Wall R, Casey PG, O'Sullivan O, Shanahan F, Hill C, Cotter PD, Fitzgerald GF, Ross RP, Caplice NM, Stanton C.J Nutr. 2014 Dec;144(12):1956-62. doi: 10.3945/jn.114.191627. Epub 2014 Oct 15.PMID: 25320181 Free article.

 

Fibrin as a delivery system in wound healing tissue engineering applications.

Whelan D, Caplice NM, Clover AJ.J Control Release. 2014 Dec 28;196:1-8. doi: 10.1016/j.jconrel.2014.09.023. Epub 2014 Oct 2.PMID: 25284479 Review.

 

 

Allogeneic mesenchymal stem cells, but not culture modified monocytes, improve burn wound healing.

Clover AJ, Kumar AH, Isakson M, Whelan D, Stocca A, Gleeson BM, Caplice NM.Burns. 2015 May;41(3):548-57. doi: 10.1016/j.burns.2014.08.009. Epub 2014 Sep 16.PMID: 25234958

 

Intravascular cell delivery device for therapeutic VEGF-induced angiogenesis in chronic vascular occlusion.

Kumar AH, Martin K, Doyle B, Huang CL, Pillai GK, Ali MT, Skelding KA, Wang S, Gleeson BM, Jahangeer S, Ritman EL, Russell SJ, Caplice NM.Biomaterials. 2014 Oct;35(32):9012-22. doi: 10.1016/j.biomaterials.2014.07.016. Epub 2014 Aug 2.PMID: 25096850 Free article.

 

Role of the gut in modulating lipoprotein metabolism.

Hennessy AA, Ross RP, Fitzgerald GF, Caplice N, Stanton C.Curr Cardiol Rep. 2014 Aug;16(8):515. doi: 10.1007/s11886-014-0515-2.PMID: 24950675 Review.

 

Identification of a Klf4-dependent upstream repressor region mediating transcriptional regulation of the myocardin gene in human smooth muscle cells.

Turner EC, Huang CL, Govindarajan K, Caplice NM.Biochim Biophys Acta. 2013 Nov;1829(11):1191-201. doi: 10.1016/j.bbagrm.2013.09.002. Epub 2013 Sep 21.PMID: 24060351

 

Regenerative approaches to post-myocardial infarction heart failure.

Martin K, Huang CL, Caplice NM.Curr Pharm Des. 2014;20(12):1930-40. doi: 10.2174/13816128113199990450.PMID: 23844736 Review.

 

Differential endothelial coverage, response to injury and neointimal integration of CX3CR1/smooth muscle-like cells after carotid or femoral arterial injury.

Martin K, Kumar AH, Klinkert K, Caplice NM.J Vasc Res. 2013;50(3):200-9. doi: 10.1159/000350532. Epub 2013 May 3.PMID: 23653073

 

Pregnancy-specific glycoproteins bind integrin αIIbβ3 and inhibit the platelet-fibrinogen interaction.

Shanley DK, Kiely PA, Golla K, Allen S, Martin K, O'Riordan RT, Ball M, Aplin JD, Singer BB, Caplice N, Moran N, Moore T.PLoS One. 2013;8(2):e57491. doi: 10.1371/journal.pone.0057491. Epub 2013 Feb 28.PMID: 23469002 Free PMC article.

 

Role of CX3CR1 receptor in monocyte/macrophage driven neovascularization.

Kumar AH, Martin K, Turner EC, Buneker CK, Dorgham K, Deterre P, Caplice NM.PLoS One. 2013;8(2):e57230. doi: 10.1371/journal.pone.0057230. Epub 2013 Feb 21.PMID: 23437346 Free PMC article.

 

Multidetector computed tomography accurately defines infarct size, but not microvascular obstruction after myocardial infarction.

O'Sullivan JF, Leblond AL, O'Dea J, Hristova I, Kumar S, Martin K, Kumar AH, Caplice NM.J Am Coll Cardiol. 2013 Jan 15;61(2):208-10. doi: 10.1016/j.jacc.2012.08.1014. Epub 2012 Nov 21.PMID: 23177294 Free article. No abstract available.

 

Surface chemical and physical modification in stent technology for the treatment of coronary artery disease.

Nazneen F, Herzog G, Arrigan DW, Caplice N, Benvenuto P, Galvin P, Thompson M.J Biomed Mater Res B Appl Biomater. 2012 Oct;100(7):1989-2014. doi: 10.1002/jbm.b.32772. Epub 2012 Jul 30.PMID: 22949314 Review.

 

Potent endothelial progenitor cell-conditioned media-related anti-apoptotic, cardiotrophic, and pro-angiogenic effects post-myocardial infarction are mediated by insulin-like growth factor-1.

Hynes B, Kumar AH, O'Sullivan J, Klein Buneker C, Leblond AL, Weiss S, Schmeckpeper J, Martin K, Caplice NM.Eur Heart J. 2013 Mar;34(10):782-9. doi: 10.1093/eurheartj/ehr435. Epub 2011 Dec 15.PMID: 22173909

 

Calcium signalling in adult endothelial outgrowth cells.

Pierce WG, Zanette C, Caplice NM, Mackrill JJ.Biochem Biophys Res Commun. 2012 Jan 6;417(1):358-63. doi: 10.1016/j.bbrc.2011.11.115. Epub 2011 Dec 1.PMID: 22155247

 

Deficiency of CX3CR1 delays burn wound healing and is associated with reduced myeloid cell recruitment and decreased sub-dermal angiogenesis.

Clover AJ, Kumar AH, Caplice NM.Burns. 2011 Dec;37(8):1386-93. doi: 10.1016/j.burns.2011.08.001. Epub 2011 Sep 15.PMID: 21924836

 

New therapeutic potential of microRNA treatment to target vulnerable atherosclerotic lesions and plaque rupture.

Martin K, O'Sullivan JF, Caplice NM.Curr Opin Cardiol. 2011 Nov;26(6):569-75. doi: 10.1097/HCO.0b013e32834b7f95.PMID: 21918434 Review.

 

Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.

O'Sullivan JF, Leblond AL, Kelly G, Kumar AH, Metharom P, Büneker CK, Alizadeh-Vikali N, Hristova I, Hynes BG, O'Connor R, Caplice NM.Circ Cardiovasc Interv. 2011 Aug;4(4):327-35. doi: 10.1161/CIRCINTERVENTIONS.110.960765. Epub 2011 Jun 28.PMID: 21712526

 

Role of vessel wall and bone marrow syndecan-4 in neointimal hyperplasia: the plot thickens.

Caplice NM.Arterioscler Thromb Vasc Biol. 2011 May;31(5):952-3. doi: 10.1161/ATVBAHA.111.225557.PMID: 21508338 No abstract available.

 

Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target.

Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM.Atherosclerosis. 2011 May;216(1):74-82. doi: 10.1016/j.atherosclerosis.2011.01.037. Epub 2011 Feb 2.PMID: 21333993

 

Improved protocol for processing stented porcine coronary arteries for immunostaining.

Kumar AH, McCauley SD, Hynes BG, O'Dea J, Caplice NM.J Mol Histol. 2011 Apr;42(2):187-93. doi: 10.1007/s10735-011-9316-8. Epub 2011 Feb 9.PMID: 21305341

 

Microribonucleic acids for prevention of plaque rupture and in-stent restenosis: "a finger in the dam".

O'Sullivan JF, Martin K, Caplice NM.J Am Coll Cardiol. 2011 Jan 25;57(4):383-9. doi: 10.1016/j.jacc.2010.09.029.PMID: 21251577 Free article. Review.

 

Contrast-enhanced ultrasound and the enigma of plaque neovascularization.

Caplice NM, Martin K.JACC Cardiovasc Imaging. 2010 Dec;3(12):1273-5. doi: 10.1016/j.jcmg.2010.11.005.PMID: 21163456 Free article. No abstract available.

 

Differential filamentation of Candida albicans and Candida dubliniensis Is governed by nutrient regulation of UME6 expression.

O'Connor L, Caplice N, Coleman DC, Sullivan DJ, Moran GP.Eukaryot Cell. 2010 Sep;9(9):1383-97. doi: 10.1128/EC.00042-10. Epub 2010 Jul 16.PMID: 20639413 Free PMC article.

 

Clinical potential of adult vascular progenitor cells.

Kumar AH, Caplice NM.Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1080-7. doi: 10.1161/ATVBAHA.109.198895. Epub 2010 May 7.PMID: 20453166 Review.

 

A specific subset of mouse bone marrow cells has smooth muscle cell differentiation capacity-brief report.

Metharom P, Kumar AH, Weiss S, Caplice NM.Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):533-5. doi: 10.1161/ATVBAHA.109.200097. Epub 2009 Dec 10.PMID: 20007909

 

Bone marrow-derived CX3CR1 progenitors contribute to neointimal smooth muscle cells via fractalkine CX3CR1 interaction.

Kumar AH, Metharom P, Schmeckpeper J, Weiss S, Martin K, Caplice NM.FASEB J. 2010 Jan;24(1):81-92. doi: 10.1096/fj.09-132225. Epub 2009 Sep 10.PMID: 19745110

 

Lentiviral tracking of vascular differentiation in bone marrow progenitor cells.

Schmeckpeper J, Ikeda Y, Kumar AH, Metharom P, Russell SJ, Caplice NM.Differentiation. 2009 Sep-Oct;78(2-3):169-76. doi: 10.1016/j.diff.2009.01.002. Epub 2009 Feb 20.PMID: 19715661

 

Thrombin stimulates smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.

Martin K, Weiss S, Metharom P, Schmeckpeper J, Hynes B, O'Sullivan J, Caplice N.Circ Res. 2009 Jul 31;105(3):214-8. doi: 10.1161/CIRCRESAHA.109.199984. Epub 2009 Jul 2.PMID: 19574550 Free article.

 

Myeloid lineage of human endothelial outgrowth cells circulating in blood and vasculogenic endothelial-like cells in the diseased vessel wall.

Liu C, Wang S, Metharom P, Caplice NM.J Vasc Res. 2009;46(6):581-91. doi: 10.1159/000226226. Epub 2009 Jun 30.PMID: 19571578

 

Bone marrow mononuclear stem cells: potential in the treatment of myocardial infarction.

Leblond AL, O'Sullivan J, Caplice N.Stem Cells Cloning. 2009 Dec 4;2:11-9. doi: 10.2147/sccaa.s6210.PMID: 24198506 Free PMC article. Review.

 

 

 

Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1.

Doyle B, Sorajja P, Hynes B, Kumar AH, Araoz PA, Stalboerger PG, Miller D, Reed C, Schmeckpeper J, Wang S, Liu C, Terzic A, Kruger D, Riederer S, Caplice NM.Stem Cells Dev. 2008 Oct;17(5):941-51. doi: 10.1089/scd.2007.0214.PMID: 18564032 Free PMC article.

 

Fractalkine in rheumatoid arthritis: a review to date.

Murphy G, Caplice N, Molloy M.Rheumatology (Oxford). 2008 Oct;47(10):1446-51. doi: 10.1093/rheumatology/ken197. Epub 2008 May 21.PMID: 18495821 Review.

 

Progression of nonculprit plaque stenosis following successful percutaneous intervention.

Bunch TJ, Rihal CS, Gumina RJ, Cooper L, Caplice NM.Angiology. 2008 Apr-May;59(2):236-9. doi: 10.1177/0003319707306446. Epub 2008 Apr 2.PMID: 18388075

 

Myeloid lineage of high proliferative potential human smooth muscle outgrowth cells circulating in blood and vasculogenic smooth muscle-like cells in vivo.

Metharom P, Liu C, Wang S, Stalboerger P, Chen G, Doyle B, Ikeda Y, Caplice NM.Atherosclerosis. 2008 May;198(1):29-38. doi: 10.1016/j.atherosclerosis.2007.09.020. Epub 2007 Oct 25.PMID: 17963771

 

Dynamic tracking during intracoronary injection of 18F-FDG-labeled progenitor cell therapy for acute myocardial infarction.

Doyle B, Kemp BJ, Chareonthaitawee P, Reed C, Schmeckpeper J, Sorajja P, Russell S, Araoz P, Riederer SJ, Caplice NM.J Nucl Med. 2007 Oct;48(10):1708-14. doi: 10.2967/jnumed.107.042838.PMID: 17909258 Free article.

 

Plaque neovascularization and antiangiogenic therapy for atherosclerosis.

Doyle B, Caplice N.J Am Coll Cardiol. 2007 May 29;49(21):2073-80. doi: 10.1016/j.jacc.2007.01.089. Epub 2007 May 17.PMID: 17531655 Free article. Review.

 

Neoangiogenesis and the presence of progenitor cells in the venous limb of an arteriovenous fistula in the rat.

Caplice NM, Wang S, Tracz M, Croatt AJ, Grande JP, Katusic ZS, Nath KA.Am J Physiol Renal Physiol. 2007 Aug;293(2):F470-5. doi: 10.1152/ajprenal.00067.2007. Epub 2007 Mar 6.PMID: 17344190 Free PMC article.

 

Vascular disease: a new progenitor biology.

Metharom P, Caplice NM.Curr Vasc Pharmacol. 2007 Jan;5(1):61-8. doi: 10.2174/157016107779317215.PMID: 17266614 Review.

 

Clinical trials in stem cell therapy: pitfalls and lessons for the future.

Metharom P, Doyle B, Caplice NM.Nat Clin Pract Cardiovasc Med. 2007 Feb;4 Suppl 1:S96-9. doi: 10.1038/ncpcardio0730.PMID: 17230223

 

 

Endothelial progenitor cells.

Doyle B, Metharom P, Caplice NM.Endothelium. 2006 Nov-Dec;13(6):403-10. doi: 10.1080/10623320601061656.PMID: 17169772 Review.

 

Infected cell carriers: a new strategy for systemic delivery of oncolytic measles viruses in cancer virotherapy.

Iankov ID, Blechacz B, Liu C, Schmeckpeper JD, Tarara JE, Federspiel MJ, Caplice N, Russell SJ.Mol Ther. 2007 Jan;15(1):114-22. doi: 10.1038/sj.mt.6300020.PMID: 17164782 Free article.

 

Targeting angiogenesis versus myogenesis with cardiac cell therapy.

Doyle B, Caplice NM.Expert Rev Cardiovasc Ther. 2006 Sep;4(5):745-53. doi: 10.1586/14779072.4.5.745.PMID: 17081096 Review.

 

Nephrogenic fibrosing dermopathy and high-dose erythropoietin therapy.

Swaminathan S, Ahmed I, McCarthy JT, Albright RC, Pittelkow MR, Caplice NM, Griffin MD, Leung N.Ann Intern Med. 2006 Aug 1;145(3):234-5. doi: 10.7326/0003-4819-145-3-200608010-00021.PMID: 16880475 No abstract available.

 

PAF-receptor is preferentially expressed in a distinct synthetic phenotype of smooth muscle cells cloned from human internal thoracic artery: functional implications in cell migration.

Stengel D, O'Neil C, Brochériou I, Karabina SA, Durand H, Caplice NM, Pickering JG, Ninio E.Biochem Biophys Res Commun. 2006 Aug 4;346(3):693-9. doi: 10.1016/j.bbrc.2006.05.210. Epub 2006 Jun 12.PMID: 16793019

 

 

Impact of transforming growth factor-beta1 on atrioventricular node conduction modification by injected autologous fibroblasts in the canine heart.

Bunch TJ, Mahapatra S, Bruce GK, Johnson SB, Miller DV, Horne BD, Wang XL, Lee HC, Caplice NM, Packer DL.Circulation. 2006 May 30;113(21):2485-94. doi: 10.1161/CIRCULATIONAHA.105.570796. Epub 2006 May 22.PMID: 16717152

 

The future of cell therapy for acute myocardial infarction.

Caplice NM.Nat Clin Pract Cardiovasc Med. 2006 Mar;3 Suppl 1:S129-32. doi: 10.1038/ncpcardio0432.PMID: 16501619

 

TFPI antigen and activity levels in patients with asymptomatic atherosclerosis and target organ acute and chronic complications.

Novo G, Caplice N, Tantillo R, Bonura F, Simari R, Novo S.Int Angiol. 2005 Dec;24(4):366-71.PMID: 16355095

 

Letter regarding article by Rotmans et al, "In vivo cell seeding with anti-CD34 antibodies successfully accelerates endothelialization but stimulates intimal hyperplasia in porcine arteriovenous expanded polytetrafluoroethylene grafts".

Doyle B, Caplice N.Circulation. 2005 Dec 13;112(24):e359; author reply e359-60. doi: 10.1161/CIRCULATIONAHA.105.575688.PMID: 16344395 No abstract available.

 

Cyclosporine decreases vascular progenitor cell numbers after cardiac transplantation and attenuates progenitor cell growth in vitro.

Davies WR, Wang S, Oi K, Bailey KR, Tazelaar HD, Caplice NM, McGregor CG.J Heart Lung Transplant. 2005 Nov;24(11):1868-77. doi: 10.1016/j.healun.2005.04.004. Epub 2005 Aug 8.PMID: 16297794

 

Cell therapy for cardiovascular disease: what cells, what diseases and for whom?

Caplice NM, Gersh BJ, Alegria JR.Nat Clin Pract Cardiovasc Med. 2005 Jan;2(1):37-43. doi: 10.1038/ncpcardio0073.PMID: 16265341 Review.

 

Myocardial-cell replacement: the science, the clinic and the future.

Caplice NM, Deb A.Nat Clin Pract Cardiovasc Med. 2004 Dec;1(2):90-5. doi: 10.1038/ncpcardio0051.PMID: 16265312 Review.

 

Bone marrow-derived myofibroblasts are present in adult human heart valves.

Deb A, Wang SH, Skelding K, Miller D, Simper D, Caplice N.J Heart Valve Dis. 2005 Sep;14(5):674-8.PMID: 16245507

 

Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension.

Rodriguez-Porcel M, Zhu XY, Chade AR, Amores-Arriaga B, Caplice NM, Ritman EL, Lerman A, Lerman LO.Am J Physiol Heart Circ Physiol. 2006 Mar;290(3):H978-84. doi: 10.1152/ajpheart.00538.2005. Epub 2005 Oct 7.PMID: 16214846 Free PMC article.

 

MCP-1 is up-regulated in unstressed and stressed HO-1 knockout mice: Pathophysiologic correlates.

Pittock ST, Norby SM, Grande JP, Croatt AJ, Bren GD, Badley AD, Caplice NM, Griffin MD, Nath KA.Kidney Int. 2005 Aug;68(2):611-22. doi: 10.1111/j.1523-1755.2005.00439.x.PMID: 16014038 Free article.

 

Proapoptotic, antimigratory, antiproliferative, and antiangiogenic effects of commercial C-reactive protein on various human endothelial cell types in vitro: implications of contaminating presence of sodium azide in commercial preparation.

Liu C, Wang S, Deb A, Nath KA, Katusic ZS, McConnell JP, Caplice NM.Circ Res. 2005 Jul 22;97(2):135-43. doi: 10.1161/01.RES.0000174612.90094.fd. Epub 2005 Jun 23.PMID: 15976313 Free article.

 

A new source of endothelial progenitor cells--vascular biology redefined?

Doyle B, Caplice N.Trends Biotechnol. 2005 Sep;23(9):444-6. doi: 10.1016/j.tibtech.2005.05.013.PMID: 15951038 Review.

 

Leptin receptor and functional effects of leptin in human endothelial progenitor cells.

Wolk R, Deb A, Caplice NM, Somers VK.Atherosclerosis. 2005 Nov;183(1):131-9. doi: 10.1016/j.atherosclerosis.2005.03.048. Epub 2005 Jun 13.PMID: 15950978

 

Vascular progenitor cells: origin and mechanisms of mobilization, differentiation, integration, and vasculogenesis.

Caplice NM, Doyle B.Stem Cells Dev. 2005 Apr;14(2):122-39. doi: 10.1089/scd.2005.14.122.PMID: 15910239 Review.

 

Unresolved questions, changing definitions, and novel paradigms for defining endothelial progenitor cells.

Ingram DA, Caplice NM, Yoder MC.Blood. 2005 Sep 1;106(5):1525-31. doi: 10.1182/blood-2005-04-1509. Epub 2005 May 19.PMID: 15905185 Free article. Review.

 

Transgenic sickle mice are markedly sensitive to renal ischemia-reperfusion injury.

Nath KA, Grande JP, Croatt AJ, Frank E, Caplice NM, Hebbel RP, Katusic ZS.Am J Pathol. 2005 Apr;166(4):963-72. doi: 10.1016/S0002-9440(10)62318-8.PMID: 15793278 Free PMC article.

 

Smooth muscle progenitor cells in vascular disease.

Liu C, Nath KA, Katusic ZS, Caplice NM.Trends Cardiovasc Med. 2004 Oct;14(7):288-93. doi: 10.1016/j.tcm.2004.08.002.PMID: 15542381 Review.

 

Transplantation of circulating endothelial progenitor cells restores endothelial function of denuded rabbit carotid arteries.

He T, Smith LA, Harrington S, Nath KA, Caplice NM, Katusic ZS.Stroke. 2004 Oct;35(10):2378-84. doi: 10.1161/01.STR.0000141893.33677.5d. Epub 2004 Sep 2.PMID: 15345801

 

Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase.

He T, Peterson TE, Holmuhamedov EL, Terzic A, Caplice NM, Oberley LW, Katusic ZS.Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2021-7. doi: 10.1161/01.ATV.0000142810.27849.8f. Epub 2004 Aug 19.PMID: 15319267

 

Integrin profile and in vivo homing of human smooth muscle progenitor cells.

Deb A, Skelding KA, Wang S, Reeder M, Simper D, Caplice NM.Circulation. 2004 Oct 26;110(17):2673-7. doi: 10.1161/01.CIR.0000139842.15651.B2. Epub 2004 Aug 16.PMID: 15313945

 

Lipoprotein(a): new insights into mechanisms of atherogenesis and thrombosis.

Deb A, Caplice NM.Clin Cardiol. 2004 May;27(5):258-64. doi: 10.1002/clc.4960270503.PMID: 15188938 Free PMC article. Review.

 

 

 

Dog peritoneal and pleural cavities as bioreactors to grow autologous vascular grafts.

Chue WL, Campbell GR, Caplice N, Muhammed A, Berry CL, Thomas AC, Bennett MB, Campbell JH.J Vasc Surg. 2004 Apr;39(4):859-67. doi: 10.1016/j.jvs.2003.03.003.PMID: 15071455 Free article.

 

Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia.

Zhu XY, Rodriguez-Porcel M, Bentley MD, Chade AR, Sica V, Napoli C, Caplice N, Ritman EL, Lerman A, Lerman LO.Circulation. 2004 May 4;109(17):2109-15. doi: 10.1161/01.CIR.0000125742.65841.8B. Epub 2004 Mar 29.PMID: 15051643

 

Fatal coronary artery disease after unrelated donor bone marrow transplantation.

Ghobrial IM, Bunch TJ, Caplice NM, Edwards WD, Miller DV, Litzow MR.Mayo Clin Proc. 2004 Mar;79(3):403-6. doi: 10.4065/79.3.403.PMID: 15008613

 

Nitric oxide synthase gene transfer as a tool to study biology of endothelial cells.

Katusic ZS, Caplice NM, Nath KA.Arterioscler Thromb Vasc Biol. 2003 Nov 1;23(11):1990-4. doi: 10.1161/01.ATV.0000078522.50981.55. Epub 2003 Sep 18.PMID: 14500286 Review.

 

Endothelial progenitor cells are decreased in blood of cardiac allograft patients with vasculopathy and endothelial cells of noncardiac origin are enriched in transplant atherosclerosis.

Simper D, Wang S, Deb A, Holmes D, McGregor C, Frantz R, Kushwaha SS, Caplice NM.Circulation. 2003 Jul 15;108(2):143-9. doi: 10.1161/01.CIR.0000081703.34526.5D. Epub 2003 Jun 30.PMID: 12835206 Clinical Trial.

 

Tissue factor pathway inhibitor deficiency enhances neointimal proliferation and formation in a murine model of vascular remodelling.

Singh R, Pan S, Mueske CS, Witt TA, Kleppe LS, Peterson TE, Caplice NM, Simari RD.Thromb Haemost. 2003 Apr;89(4):747-51.PMID: 12669131

 

Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow transplantation.

Caplice NM, Bunch TJ, Stalboerger PG, Wang S, Simper D, Miller DV, Russell SJ, Litzow MR, Edwards WD.Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4754-9. doi: 10.1073/pnas.0730743100. Epub 2003 Mar 28.PMID: 12665618 Free PMC article.

 

Bone marrow-derived cardiomyocytes are present in adult human heart: A study of gender-mismatched bone marrow transplantation patients.

Deb A, Wang S, Skelding KA, Miller D, Simper D, Caplice NM.Circulation. 2003 Mar 11;107(9):1247-9. doi: 10.1161/01.cir.0000061910.39145.f0.PMID: 12628942

 

Molecular biology and gene transfer in atherosclerosis in the stenting era.

Caplice NM, Simari RD, Holmes DR.Int J Cardiovasc Intervent. 1999;2(3):141-152. doi: 10.1080/acc.2.3.141.152.PMID: 12623583

 

Infectious and ischemic complications from percutaneous closure devices used after vascular access.

Boston US, Panneton JM, Hofer JM, Sabater EA, Caplice N, Rowland CM, Noel AA, Bower TC, Cherry KJ Jr, Gloviczki P.Ann Vasc Surg. 2003 Jan;17(1):66-71. doi: 10.1007/s10016-001-0338-7. Epub 2003 Jan 15.PMID: 12522702

 

Stem cells to repair the heart: a clinical perspective.

Caplice NM, Gersh BJ.Circ Res. 2003 Jan 10;92(1):6-8. doi: 10.1161/01.res.0000052826.35667.40.PMID: 12522113 Free article. No abstract available.

 

Smooth muscle progenitor cells in human blood.

Simper D, Stalboerger PG, Panetta CJ, Wang S, Caplice NM.Circulation. 2002 Sep 3;106(10):1199-204. doi: 10.1161/01.cir.0000031525.61826.a8.PMID: 12208793

 

EST-based identification of genes expressed in the liver of adult Atlantic salmon (Salmo salar).

Martin SA, Caplice NC, Davey GC, Powell R.Biochem Biophys Res Commun. 2002 Apr 26;293(1):578-85. doi: 10.1016/S0006-291X(02)00263-2.PMID: 12054641

 

A tissue-engineered stent for cell-based vascular gene transfer.

Panetta CJ, Miyauchi K, Berry D, Simari RD, Holmes DR, Schwartz RS, Caplice NM.Hum Gene Ther. 2002 Feb 10;13(3):433-41. doi: 10.1089/10430340252792567.PMID: 11860710

 

Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects.

Rajamannan NM, Caplice N, Anthikad F, Sebo TJ, Orszulak TA, Edwards WD, Tajik J, Schwartz RS.J Heart Valve Dis. 2001 Nov;10(6):827-31.PMID: 11767194

 

Lipoprotein (a) binds and inactivates tissue factor pathway inhibitor: a novel link between lipoproteins and thrombosis.

Caplice NM, Panetta C, Peterson TE, Kleppe LS, Mueske CS, Kostner GM, Broze GJ Jr, Simari RD.Blood. 2001 Nov 15;98(10):2980-7. doi: 10.1182/blood.v98.10.2980.PMID: 11698280 Free article.

 

Plasmin proteolysis of endothelial cell and vessel wall associated tissue factor pathway inhibitor.

Stalboerger PG, Panetta CJ, Simari RD, Caplice NM.Thromb Haemost. 2001 Sep;86(3):923-8.PMID: 11583328

 

Role for tissue factor pathway in murine model of vascular remodeling.

Singh R, Pan S, Mueske CS, Witt T, Kleppe LS, Peterson TE, Slobodova A, Chang JY, Caplice NM, Simari RD.Circ Res. 2001 Jul 6;89(1):71-6. doi: 10.1161/hh1301.092508.PMID: 11440980 Free article.

 

Remnant lipoproteins induce endothelial plasminogen activator inhibitor-1.

Sawka AM, Singh RJ, Hiddinga HJ, McConnell JP, Eberhardt NL, Caplice NM, O'Brien T.Biochem Biophys Res Commun. 2001 Jul 6;285(1):15-9. doi: 10.1006/bbrc.2001.5117.PMID: 11437365

 

A survey of genes in the Atlantic salmon (Salmo salar) as identified by expressed sequence tags.

Davey GC, Caplice NC, Martin SA, Powell R.Gene. 2001 Jan 24;263(1-2):121-30. doi: 10.1016/s0378-1119(00)00587-4.PMID: 11223250

 

Biologic alternatives to stents and grafts.

Caplice NM.Curr Cardiol Rep. 2001 Jan;3(1):17-21. doi: 10.1007/s11886-001-0005-1.PMID: 11139794 Review.

 

The Artificial Artery.

Caplice NM.Curr Interv Cardiol Rep. 2000 Feb;2(1):7-10.PMID: 11096645

 

Gene Transfer for Coronary Restenosis.

Caplice N, Simari R.Curr Interv Cardiol Rep. 1999 Jul;1(2):157-164.PMID: 11096620 No abstract available.

 

Decreasing mortality with primary percutaneous coronary intervention in patients with acute myocardial infarction: the Mayo Clinic experience from 1991 through 1997.

Velianou JL, Wilson SH, Reeder GS, Caplice NM, Grill DE, Holmes DR Jr, Bell MR.Mayo Clin Proc. 2000 Oct;75(10):994-1001. doi: 10.4065/75.10.994.PMID: 11040846

 

The regulation of caveolin expression and localization by serum and heparin in vascular smooth muscle cells.

Peterson TE, Kleppe LS, Caplice NM, Pan S, Mueske CS, Simari RD.Biochem Biophys Res Commun. 1999 Nov 30;265(3):722-7. doi: 10.1006/bbrc.1999.1738.PMID: 10600487

 

Activated nuclear factor-kappaB is present in the coronary vasculature in experimental hypercholesterolemia.

Wilson SH, Caplice NM, Simari RD, Holmes DR Jr, Carlson PJ, Lerman A.Atherosclerosis. 2000 Jan;148(1):23-30. doi: 10.1016/s0021-9150(99)00211-7.PMID: 10580167

 

The role of gene therapy for intimal hyperplasia of bypass grafts.

Cable DG, Caccitolo JA, Caplice N, O'Brien T, Simari RD, Daly RC, Dearani JA, Mullany CJ, Orszulak TA, Schaff HV.Circulation. 1999 Nov 9;100(19 Suppl):II392-6. doi: 10.1161/01.cir.100.suppl_2.ii-392.PMID: 10567335

 

Modification of molecular events in coronary restenosis using coated stents: The Mayo Clinic Approach.

Keelan PC, Miyauchi K, Caplice NM, Ashai KH, Schwartz RS.Semin Interv Cardiol. 1998 Sep-Dec;3(3-4):211-5.PMID: 10406696 Review.

 

Expression of tissue factor pathway inhibitor in vascular smooth muscle cells and its regulation by growth factors.

Caplice NM, Mueske CS, Kleppe LS, Peterson TE, Broze GJ Jr, Simari RD.Circ Res. 1998 Dec 14-28;83(12):1264-70. doi: 10.1161/01.res.83.12.1264.PMID: 9851943 Free article.

 

Presence of tissue factor pathway inhibitor in human atherosclerotic plaques is associated with reduced tissue factor activity.

Caplice NM, Mueske CS, Kleppe LS, Simari RD.Circulation. 1998 Sep 15;98(11):1051-7. doi: 10.1161/01.cir.98.11.1051.PMID: 9736590

 

Growth factors released into the coronary circulation after vascular injury promote proliferation of human vascular smooth muscle cells in culture.

Caplice NM, Aroney CN, Bett JH, Cameron J, Campbell JH, Hoffmann N, McEniery PT, West MJ.J Am Coll Cardiol. 1997 Jun;29(7):1536-41. doi: 10.1016/s0735-1097(97)00076-4.PMID: 9180116 Free article.

 

Inhibition of human vascular smooth muscle cell growth by heparin.

Caplice NM, West MJ, Campbell GR, Campbell J.Lancet. 1994 Jul 9;344(8915):97-8. doi: 10.1016/s0140-6736(94)91283-1.PMID: 7912394

 

 

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