NMR Services

NMR Services

Nuclear magnetic resonance (NMR) spectroscopy - based on the interaction of matter (chemical compounds) with electromagnetic energy (radio frequency range) in the presence of a magnetic field, is widely employed by chemists for the determination of molecular structure, the study of molecular properties, and chemical reaction dynamics. A related technique, magnetic resonance imaging (MRI) is used in clinical medicine.

The Analytical and Biological Research Facility at UCC has developed a major initiative in NMR spectroscopy. This encompasses four specialised Bruker NMR spectrometers that support a broad spectrum of teaching and research activities at undergraduate and postgraduate level. Each instrument is located in dedicated, air-conditioned laboratories in the Kane Building and Cavanagh School of Pharmacy Building, UCC. 

UCC now has excellent NMR facilities for chemistry teaching and research in the following areas: determination of molecular structure and stereochemistry, investigation of reaction mechanisms, conformational analysis of organic molecules, heterocyclic chemistry, enantioselective synthesis of bio-active compounds, pharmaceutical chemistry, palladium complexes related to anti-cancer compounds, catalysis and materials. Collaborative, NMR linked projects with the biological and food sciences and the Irish pharmaceutical industry are envisaged, in the areas of process research and development, protein structure and metabolomics. 

For NMR services to industry, please contact Dr Daniel G McCarthy/Dr Lorraine Bateman on +353-21-4901670


  • Available on open access via ICONNMR for authorized users 
  • BACS-60 sample changer, which permits optimum use of instrument time and rapid sample processing
  • Equipped with a 5 mm broadband multinuclear probe with ATMA, BOSS-II shim set, Z1 gradient controller and variable temperature facility (- 60 oC to + 180 oC); a dedicated 11B NMR probe with proton decoupling channel, 
  • HPxw4300 workstation and TOPSPIN (1.3) software operating system.
  • Available on open access via ICONNMR for authorized users 
  • BACS-60 sample changer, which permits optimum use of instrument time and rapid sample processing
  • Equipped with a 5 mm QNP probe( 1H, 13C, 31P, 19F)  with BOSS-II shim set, Z-1 gradient controller, probe heater
  • HPxw4300 workstation TOPSPIN (1.3) operating software
  • BRUKER NMR GLP license

The 400 MHz spectrometer was kindly donated by Pfizer to UCC in 2008.  A joint collaboration has been established between the two parties and has enhanced UCC's reputation as a world-class research institution and educator in state-of the-art research and technology for Ireland's rapidly developing pharmaceutical industry. The facility is used daily by researchers from both the ABCRF and the Pfizer Process Development Centre in Cork. 

Link to http://www.ucc.ie/en/abcrf/news/fullstory,67337,en.html


  • Advanced user access via ICONNMR
  • SIXPACK sample changer
  • Equipped with a 5 mm dual C/H probe, Z1 gradient, a 5 mm QNP (1H, 13C, 31P, 19F) probe, with ATMA, BOSS-II shim set, Z1 gradient controller, 2H lock switch
  • Variable temperature capability (including NMR experiments at -90o C on dual C/H  probe), BCU-05 sample chiller
  • HPxw4300 workstation and TOPSPIN  (1.3) software
  • BRUKER NMR GLP license

BRUKER AVANCE 600 UltraShieldTM NMR spectrometer with CryoProbeTM technology

 

  • 600 MHz UltraShieldTM magnet
  • Advanced user access via ICONNMR
  • AVANCE III digital NMR console
  • CryoProbeTM technology for increased sensitivity
  • SAMPLEJET sample changer with a 47 position carousel and capacity for up to 480 additional tubes via five 96-well plate arrangement
  • Equipped with GRASP accessory for gradient spectroscopy, BOSS-II shim set, Z1 gradient controller, 3-channel amplifier, BCU-05 sample chiller
  • Standard probes: BBO 109Ag – 31P with proton decoupling Z1-gradient and ATMA; TXI 1H – 13C – 15N with proton decoupling, Z1-gradient and ATMA
  • Cryoprobes: CPDCH – 1H and 13C observe with Z1 gradient and proton decoupling with ATMA;  CPTCI – inverse triple resonance probe with 1H observe with 13C and 15N decoupling, Z1 gradient with ATMA
  • Variable temperature capability
  • HPxw4600 workstation and TOPSPIN (2.1) software
  • BRUKER NMR GLP license

 

The 600MHz NMR spectrometer, commissioned in November 2008 was co-funded by the HEA and NDP (through PRTLI 4), and SFI.  

      

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