Fast Reaction Kinectics in NMR Spectroscopy using InsightXpress

The Analytical and Biological Chemistry Research Facility (ABCRF) at University College Cork (UCC) has recently installed a state-of-the-art NMR spectroscopy infrastructure, featuring a Bruker InsightXpress MR system. This advanced system enables the spectroscopic monitoring of extremely fast (millisecond) reactions, a capability that has not been possible for NMR to date.

The Fast reaction kinetics in NMR Spectroscopy (FaNS) infrastructure is a significant addition to the existing Process Flow Spectroscopy (ProSpect) facility, which offers state-of-the-art real-time analysis of both batch and continuous reaction processes. It includes a dedicated InsightXpress MR system equipped with a stopped-flow pump and precisely timed trigger pulse, facilitating the rapid mixing of reagents at the NMR spectrometer. This system is integrated with a Bruker Ascend Evo 400 MHz superconducting magnet and powered by a Bruker Avance III NEO console, which offers enhanced configuration options with its two channels for maximum 1D/2D experiment choice.

A significant technological advancement is the in-built UltraShield cryogenic cooling technology, which dramatically improves liquid helium and liquid nitrogen hold times. This innovation represents a major environmental, cost, and sustainability improvement.

Additionally, the University has acquired a liquid nitrogen plant. Liquid nitrogen is a crucial resource for a wide range of research activities, with the majority of its use dedicated to NMR spectroscopy. On-site generation of liquid nitrogen ensures a constant supply without interruption, substantially reducing both the cost and carbon footprint associated with its provision.

External Projects & Enquiries

FaNS was funded through a Taighde Éireann Research Ireland (formerly Science Foundation Ireland) Infrastructure Award (SFI 21/RI/9705). This new infrastructure marks a significant leap forward in the University's research capabilities, positioning it at the forefront of scientific innovation and sustainability.

For more information, please contact:

Analytical & Biological Chemistry Research Facility (ABCRF)

Saoráid Taighde Ceimice Anailísí agus Bitheolaíochta

FaNS facility is open to projects from external users, both in industry and academia. Requests for information should be directed to Dr Lorraine Bateman.