Publications
Insulin resistance in primary nephrotic syndrome; is kidney function truly normal?
We read with great interest the article by Jin et al. which examined the association between the nephrotic syndrome and insulin resistance. We have recently conducted a cross-sectional study of arterial stiffness in adult patients with primary nephrotic syndrome without diabetes mellitus. We have also gathered information on glycosylated haemoglobin levels (HBA1c) in adult patients with the nephrotic syndrome, the findings of which are relevant to the study by Jin et al..
- Authors
Sexton DJ, Eustace JA.
- Year
- 2014
- Journal Name
- Pediatric Nephrology
- Category
- Journal Article
- Link to Publication
- https://doi.org/10.1007/s00467-012-2343-1
Abstract
We read with great interest the article by Jin et al. which examined the association between the nephrotic syndrome and insulin resistance. We have recently conducted a cross-sectional study of arterial stiffness in adult patients with primary nephrotic syndrome without diabetes mellitus. We have also gathered information on glycosylated haemoglobin levels (HBA1c) in adult patients with the nephrotic syndrome, the findings of which are relevant to the study by Jin et al..
Recent reports suggest that HBA1c levels at the upper end of normal between 5.4 and 5.8 % are associated with impaired insulin secretion and that levels greater than 5.9 % are associated with significant reductions in insulin sensitivity and β cell dysfunction. Our findings are in line with those reported by Jin et al. in that they suggest some degree of insulin resistance in patients with the nephrotic syndrome with preserved renal function.