Recent Publications

Marshall, S, Fleming, A, Moore AC, Sahm LJ.

Acceptability of microneedle-patch vaccines: A qualitative analysis of the opinions of parents.

Vaccine (2017), Aug 2. pii: 20264-410X(17)31009-5.

 

Dan-Dan Song, Tong-Tong Zhang, Jia-Li Chen, Yun-Fei Xia, Zheng-Hong Qin, Christian Waeber, Rui Sheng.

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Cell Death and Disease (2017) 8, e2912

 

Sobrino A, Vallejo s, Novella S, Lázaro-Franco M, Mompeón A, Bueno-Betí C, Walther T, Sánchez Ferrer C, Pieró C, Hermenegildo C.

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

Biochem Pharmacol (2017), Apr, 129:67-72

 

Meinert C, Kohse F, Boehme I, Gembardt F, Tetzner A, Wieland T, Greenberg B, Walther T.

Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells

Data in Brief (2017), February, 10:354–363

Marshall, S, Sahm, LJ, Moore, AC.

The success of microneedle-mediated vaccine delivery into skin

Human Vaccines & Immunotherapeutics (2016) DOI: 10.1080/21645515.2016.1171440

 

Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, EL Amki M, Fatar M, Carcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D.

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.

Stroke. 2016 May; 47 (5): 1312-8. 

 

Khan A, Wang Y, Schultheiss HP, Moreira Mda C, Walther T.

Role of monokine induced by interferon-gamma (MIG) in discrimation and pronosis of patients with Chagas' disease and idiopathic dilated cardiomyopathy.

J Cardiovasc Pharmacol. 2016. May; 67(5):427-32.

 

Supé S, Kohse F, Gembardt F, Kuebler WM, Walther T.

Therapeutic time window for angiotensin-(1-7) in acute lung injury.

 Br J Pharmacol. 2016. May; 173 (10): 1618-28.

 

Houston A, Williams JM, Rovis TL, Shanley DK, O'Riordan RT, Kiely PA, Ball M, Barry OP, Kelly J, Fanning A, Mac Sharry J, Mandelboim O, Singer BB, Jonjic S, Moore T.

Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies.

MAbs. 2016 Apr; 8 (3): 491-500.

 

Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžić S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH.

CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation

J Cereb Blood Flow Metab. 2016 Apr; 36 (4): 781-93 PMID: 26661156.

 

Vrdoljak A, Allen EA, Ferrara F, Temperton NJ, Crean AM, Moore AC.

Induction of Broad Immunity by Thermostabilised Vaccines Incorporated in Dissolvable Microneedles Using Novel Fabrication Methods  

 J Control Release. 2016 Mar 10; 225: 192-204. 

 

Allen EA, O'Mahony C, Cronin M, O'Mahony T, Moore AC, Crean AM. 

Dissolvable Microneedle Fabrication using Piezoelectric Dispensing Technology

The International Journal of Pharmaceutics. 2016 Mar 16; 500 (1-2):1-10.

 

Marshall S., Sahm L., Moore A.C.

Microneedle technology for immunisation: perception, acceptability and suitability for paediatric use

Vaccine, 2016 Feb 3: 34(6): 723-34 PMID: 26706274.

  

Klionsky DJ, 2211 authors, Waeber C, and … 253 more authors.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Autophagy 2016 Jan 2; 12 (1):1-222.

 

Meinert C, Gembardt F, Boehme I, Wieland T, Greenberg B, Walther T.

Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)

J Proteomics. 2016 Jan 1; 130:129-139.

 

Shiely F,Fallon D, Casey C, Kerins DM, Eustace JA.

Trial of a novel plasma gas disinfection system (Radica) to reduce mattress residual bacterial contamination in the acute hospital setting: a preliminary study.

Irish Journal of Medical Science 2016 Jan 21. [Epub ahead of print]

    

Waeber C

(2016) Cerebral blood flow methods, in "Primer on Cerebrovascular Diseases", Second Edition

Louis R. Caplan, Jose Biller, Megan Leary, Ajith Thomas, Eng Lo, Midori Yenari, and John Zhang eds., Elsevier.

 

Wong LH, Ting P, Kerins D.

Seasonal variations in nocturnal changes in blood pressure between Ireland and Singapore

Clin Trials Regul Sci Cardiol. 2015 Dec;12:12-17.

 

McCarthy, M, Bane, V, García Altares Pérezc, M, van Pelt, FNAM, Furey, A, O'Halloran J.

Assessment of emerging biotoxins (Pinnatoxin G and Spirolides) at Europe's first marine reserve: Lough Hyne 

Toxicon 2015 Dec; 108: 202-209

 

Breitling S, Krauszman A, Parihar R, Walther T, Friedberg MK, Kuebler MW.

Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension

Pulmonary Circ. 2015 Dec: 5 (4):649-657.

 

O' Callaghan C, Fanning LJ, Barry OP.

Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression

Cancers (Basel). 2015 Oct 23;7(4):2124-33. PMID: 26512696

 

Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP.

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Front Cell Neurosci. 2015 Oct 14;9:392. Review. PMID: 26528128

 

Golubeva AV, Crampton S, Desbonnet L, Edge D, O'Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW, Cryan JF.

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood.

Psychoneuroendocrinology 2015 Oct;60:58-74. PMID: 26135201

  

Kumar R, Kerins DM, Walther T.

Cardiovascular Safety of Antidiabetic Drugs

Eur Heart J CVP. 2015.

 

Klein S, Herath CB, Schierwagen R, Grace J, Haltenhof T, Uschner FE, Strassburg CP, Sauerbruch T, Walther T, Angus PW, and Trebicka J.

Hemodynamic effects of the non-peptidic angiotensin-(1-7) agonist AVE0991 in liver cirrhosis

PLoS One, 2015 Sep 25: 10 (9): 1-14.

 

Alenina N, Boehme I, Bader M, Walther T.

Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene

Gene. 2015 Sep 1: 568 (2):155-64.

 

Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM.

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

JBiol Chem. 2015 Jul 3;290(27):16502-16.

 

Pearson FE, O'Mahony C, Moore AC, Hill AV.  

Induction of CD8+ T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus vectored malaria vaccine.    

Vaccine.  (2015)  Jun 22;33(28):3248-55.

  

Boland B, Platt FM.

Bridging the age spectrum of neurodegenerative storage diseases 

Best Practice and Research: Clinical Endocrinology and Metabolism 2015 Mar; 29(2): 127-143

 

Barry OP, O'Sullivan E, and McCarthy M.

Periodic review sessions contribute to student learning across the disciplines in pharmacology

M. Journal of The Scholarship of Teaching and Learning. 2015 Feb; 15 (1): 38-56

 

O'Callaghan C, Fanning LJ, Barry OP.

p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma

Anticancer Drugs. 2015 Jan;26(1):46-55.  PMID: 25099621

 

Barry OP, O’ Sullivan E, McCarthy M.

One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class

Int J Basic Clin Pharmacol. 2015; 4(6): 1281-1289

 

Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF.

Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction

Neurogastroenterol Motil. 2015 Jan;27(1):105-13. PMID: 25443141

 

 

Clarke SF, Murphy EF, O’Sullivan O, Lucey AJ, Humphreys M, Horgan A, Hayes P, O’Reilly M, Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O’Toole PW, Molly MG, Falvey E, Shanahan F, Cotter PD.

Exercise and associated dietary extremes impact on gut microbial diversity

Gut. 2014 Dec;63(12):1913-20.

 

McCarthy M, O'Halloran J, O'Brien NM, van Pelt FN

Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?

Marine Environmental Research 2014 Oct; 101:153-160.

 

McCarthy M, van Pelt FNAM, Bane V, O'Halloran J Furey A.

Application of passive (SPATT) and active sampling methods in the profiling and monitoring of marine biotoxins

Toxicon, 2014 Oct; 89 :77-86.

 

O'Callaghan C, Fanning LJ, Barry OP.

p38δ MAPK: Emerging Roles of a Neglected Isoform

Int J Cell Biol. 2014;2014:272689. PMID: 25313309

 

O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF.

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

Neuroscience. 2014 Sep 26;277:885-901. PMID: 25088912

 

Paleco R, Vučen SR, Crean AM, Moore AC, Scalia S*.

Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles

International Journal of Pharmaceutics 2014 Sep 10; 472(1-2): 206-13.

 

Carey JB, Vrdoljak A, O'Mahony C, Hill AV, Draper SJ, Moore AC.

Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

Nature Scientific Reports. 2014 Aug 21;4:6154.

 

Hyland NP, Quigley EM, Brint EK.

Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions

World J Gastroenterol. 2014 Jul 21;20(27):8859-66. PMID:  25083059

 

Lomasney KW, Cryan JF, Hyland NP.

Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G241-7.  PMID:  24852567

 

Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C.

Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons

J Biol Chem. 2014 Jul 25; 289(30):20845-57.PMID: 24928515

 

Lomasney KW, Houston A, Shanahan F, Dinan TG, Cryan JF, Hyland NP.

Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon.

Neurogastroenterol Motil. 2014 Jun; 26(6): 887-90.

 

Wang Y, Moreira Mda C, Heringer-Walther S, Schultheiss HP, Siems W, Wessel N, Walther T.

Beta blockers prevent correlation of plasma ACE2 activity with echocardiographic parameters in patients with idiopathic dilated cardiomyopathy

J Cardiovasc Pharmacol. 2014 June; 26(6). 887-90

 

Blasi F, Wei Y, Balkaya M, Tikka S, Mandeville JB, Waeber C, Ayata C, Moskowitz MA.

Recognition memory impairments after subcortical white matter stroke in mice

Stroke. 2014 May; 45(5):1468-73 PMID: 24723319

 

Phelan M, Khaldi N, Shields DC, Kerins DM.

Angiotensin converting enzyme and nitric oxide inhibitory activities of novel milk derived peptides

International Dairy Journal 2014 Mar; 35(1):38–42

  

Waeber C, Walther T.

Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction

Circ J. 2014; 78 (4):795-802.

 

Hyland NP, Golubeva AV.

GABAB receptors in the bladder and bowel: Therapeutic potential for positive allosteric modulators?

Br J Pharmacol. 2014 Feb 12.

  

McGrath MG, Vrdoljak A, O'Mahony C, Crean AM, Moore AC.

Production of Dissolvable Microneedles using an Atomized Spray Process: Effect of Microneedle Composition on Skin Penetration 

European Journal of Pharmaceutics and Biopharmaceutics. 2014Feb;86(2):200-11.

 

Walther T, Voss A, Baumert M, Truebner S, Till H, Stepan H, Wessel N, Faber R.

Cardiovascular variability before and after accouchement: recovery from arterial stiffness in women with preeclampsia 4 days after delivery  

Hypertens Pregnancy. 2014. 33:1-14.

 

Freund M, Walther T, von Bohlen und Halbach O.

Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex

Eur Neuropsychopharm. 2014. 24:302-308.

 

O’Caoimh R, Healy L, Gao Y, Svendrovski A, Kerins DM, Eustace J, Kehoe PG, Guyatt G, Molloy DW.

Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with alzheimer's disease J Alzheimers Dis. 2014;40(3):595-603.

 

Dauphard J, Lehane M, van Pelt F, O'Halloran J, and Furey A.

Anatoxin: Chemistry, Effects, Source, Metabolism, and Detection.

Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection (2014), 3rd ed. (CRC Press), p 1061-1072.

 

Carroll SY, O'Mahony SM, Grenham S, Cryan JF, Hyland NP.

Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.

PLoS One. 2013 Dec 18;8(12)

 

Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, Szaszi K, Walther T*, Kuebler WM.

Angiotensin-(1-7) protects from experimental acute lung injury.

Crit Care Med. 2013. 41:334-343. * Corresponding author and equally contributing last author 

 

Ramirez Avila GM, Gapelyuk A, Marwan N, Stepan H, Kurths J, Walther T, Wessel N.

Classifying Healthy Women and Preeclamptic Patients from Cardiovascular Data Using Recurrence and Complex Network Methods.

 Auton Neurosci. 2013. 178:103-110.

 

Vučen SR, Vuleta G, Crean AM, Moore AC, Ignjatović N, Uskoković D.

Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles.

2013 J. Pharm. Pharmacol. (2013) Oct;65 (10):1451-62.

 

Grace JA, Klein S, Herath CB, Granzow M, Schierwagen R, Masing N, Walther T, Sauerbruch T, Burrell LM, Angus PW, Trebicka J.

The Angiotensin-(1-7)/Mas-receptor axis of the renin-angiotensin system mediates mesenteric vasodilation in cirrhosis.

Gastroenterology. 2013. 145:874-884.

 

O'Callaghan C, Fanning LJ, Houston A, Barry OP.

Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.

Int J Oncol. 2013 Aug;43(2):405-15.

 

Ramirez Avila GM, Gapelyuk A, Marwan N, Walther T, Stepan H, Kurths J, Wessel N.

Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis.

Philosophical Transactions A. 2013. 371:20110623.

 

Gao Y, O’Caoimh R, Healy L, Kerins DM, Eustace J, Guyatt G, Sammon D, Molloy DW.

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia.

BMJ Open Volume 3, Issue 7, 2013

 

Smith MT,Woodruff TM, Wyse BD, Muralidharan A, WaltherT.

A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.

Pain Med. 2013. 14:1557-1568.

 

 

Peiró C, Vallejo S, Gembardt F, Palacios E, Azcutia V, Rodríguez-Mañas L, Sánchez-Ferrer CF, Walther T.

Complete blockade of the vasorelaxant effects of Ang-(1-7) and bradykinin in murine microvessels by agonists of the receptor Mas.

J Physiol. 2013. 591:2275-2285. 

 

 

Wang Y, Khan A, Heringer-Walther S, Schultheiss HP, Moreira Mda C, Walther T.

Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy.

Cytokine. 2013. 61:728-31.  

 

Lambe T, Carey JB, Li Y, Spencer AJ, van Laarhoven A, Mullarkey CE, Vrdoljak A, Moore AC, Gilbert SC.

Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1

Nature Scientific Reports. (2013). 3: 1443.

 

Rossitto G, Regolisti G, Rossi E, Negro A, Nicoli D, Casali B, Toniato A, Caroccia B, Seccia TM, Walther T, Rossi GP.

Elevation of AT1-Receptor Autoantibodies Titer In Primary Aldosteronism Due To Aldosterone-Producing Adenoma.

Hypertension. 2013. 61:526-33.

 

Zhu X, Wang Y, Schwiebs A, Walther T.

Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB.

Mol Cell Endocrinol. 2013. 366:117-123.

 

Kerins DM, Vaughan C.

Murmurs, heart sounds and more

Book Chapter: Learning clinical skills: Pearls, pitfalls and tips for the OSCE Ed Maher B, Henn P.

2014 Elsevier B.V.

 

Goodman AL, Forbes EK, Williams AR, Douglas AD, de Cassan SC, Bauza K, Biswas S, Dicks MDJ, Llewellyn D, Moore AC, Janse CJ, Franke-Fayard BM, Gilbert SC, Hill AVS, Pleass RJ, Draper SJ.

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

Nature Scientific Reports. (2013) 1706.

 

 
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