2021 Publications

Divergent Effects of Exendin-4 and Interleukin-6 on Rat Colonic Secretory and Contractile Activity are Associated with Changes in Regional Vagal Afferent Signaling.

O'Brien, Rebecca, Maria M. Buckley, and Dervla O'Malley, Neurogastroenterology and Motility 2021, pp. e14160-e14160.

Sphingosine 1-phosphate, a potential target in neovascular retinal disease

Alshaikh RA, Ryan KB, Waeber C, British Journal of Ophthalmology Published Online First: 07 May 2021. doi: 10.1136/bjophthalmol-2021-319115

Histological, behavioural and flow cytometric datasets relating to acute ischaemic stroke in young, aged and ApoE−/− mice in the presence and absence of immunomodulation with fingolimod

Andrea C. Diaz Diaz, Kyle Malone, Jennifer A. Shearer, Anne C. Moore, Christian Waeber, Data in Brief,Volume 36,2021,107146, ISSN 2352-340

The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia

Malone, K., Diaz Diaz, A.C., Shearer, J.A. et al. J Neuroinflammation 18, 37 (2021)

Platelet hyperactivation and hyporesponsiveness at diagnosis in multiple myeloma persists during treatment initiation

O'Sullivan LR, Meade-Murphy G, Gilligan OM, Mykytiv V, Cahill MR, Young PW. Thrombosis Research 203 (8), p186-189, 2021

Adsorption, uptake and toxicity of micro- and nanoplastics: Effects on terrestrial plants and aquatic macrophytes

Alicia Mateos-Cárdenas, Frank N.A.M. van Pelt, John O’Halloran, Marcel A.K. Jansen , Environmental Pollution, Volume284,1 September 2021, 117183

Beyond Plastic Microbeads- Short-Term feeding of cellulose and polyester microfibers to the freshwater amphipod  Grammarus Dubeni 

Alicia Mateos-Cárdenas, Frank N.A.M. van Pelt, John O’Halloran, Marcel A.K. Jansen, Science of the Total Enviornment, Volume 753, 20 January 2021 , 141859

Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far' 

Colm J McElwain, Fergus P. McCarthy, Cathal M. McCarthy (2021) 'Gestational Diabetes Mellitus and Maternal Immune Dysregulation: What We Know So Far'. International Journal of Medical Sciences, 22 (8) 

'Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress?'

 Barron, Aaron; McCarthy, Cathal; O'Keeffe, Gerard (2021) 'Preeclampsia and neurodevelopmental outcomes: Potential pathogenic roles for inflammation and oxidative stress?'. Molecular Neurobiology, 

'A comparative study of two immunoassays of maternal placental growth factor'

Deirdre Hayes-Ryan, Keelin O'Donoghue, Cathal McCarthy, Ainhoa Totorika, Sarah Meaney (2021) 'A comparative study of two immunoassays of maternal placental growth factor'. Scandinavian Journal Of Clinical And Laboratory Investigation scandinavian Journal Of Clinical And Laboratory Investigation, 

 

2020 Publications

Glucagon-Like Peptide-1 Secreting L-Cells Coupled to Sensory Nerves Translate Microbial Signals to the Host Rat Nervous System

Buckley, M.M., O'Brien, R., Brosnan, E., Ross, R.P., Stanton, C., Buckley, J.M. & O'Malley, D. 2020, Frontiers in cellular neuroscience, vol. 14, pp. 95-95.

Development of electrospun polymer scaffolds for the localized and controlled delivery of siponimod for the management of critical bone defects

Ziad Sartawi, Christian Waeber, Ernestina Schipani, Katie B. Ryan, International Journal of Pharmaceutics, Volume 590,2020, 119956, ISSN 0378-5173

A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy

Jia-Li Chen, Xin-Xin Wang, Lei Chen, Jie Tang, Yun-Fei Xia, Ke Qian, Zheng-Hong Qin, Christian Waeber, Rui Sheng, Neuropharmacology, Volume 181,2020, 108326, ISSN 0028-3908

Development of Dynamic Cell and Organotypic Skin Models, for the Investigation of a Novel Viscoelastic Burns Treatment Using Molecular and Cellular Approaches.

Wallace RG, Kenealy MR, Brady AJ, Duffy E, Degryse B, Meade-Murphy G, Custaud M-A, Morrin A, Murphy RP. Burns (Journal of the International Society for Burns Injuries), 46 (7), p1585-1602, 2020.

Platelet Hyperactivation in Multiple Myeloma Is Also Evident in Patients with Premalignant Monoclonal Gammopathy of Undetermined Significance.

O'Sullivan LR, Meade-Murphy G, Gilligan OM, Mykytiv V, Young PW, Cahill MR. British Journal of Haematology, 192 (2), p322-332, 2020.

Platelet Hyperactivation in Multiple Myeloma Is Also Evident in Premalignant MGUS Patients and Persists During Treatment InitiationMM-080. 

O'Sullivan LR, Meade-Murphy G, Gilligan OM, Mykytiv V, Young PW, Cahill MR. Clinical Lymphoma Myeloma and Leukemia, 20, p S290, 2020.

Rapid fragmentation of microplastics by the freshwater amphipod Gammarus duebeni (Lillj.)

Alicia Mateos-Cárdenas, John O’Halloran, Frank N.A.M. van Pelt, Marcel A.K. Jansen, Sci Rep 10, 12799, 2020

'Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?'

Colm J McElwain, Eszter Tuboly, Fergus P. McCarthy, Cathal M. McCarthy (2020) 'Mechanisms of Endothelial Dysfunction in Pre-eclampsia and Gestational Diabetes Mellitus: Windows Into Future Cardiometabolic Health?'. Frontiers In Endocrinology, 11 (655) 

'microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression'

Fitzsimons, S;Oggero, S;Bruen, R;McCarthy, C;Strowitzki, MJ;Mahon, NG;Ryan, N;Brennan, EP;Barry, M;Perretti, M;Belton, O (2020) 'microRNA-155 Is Decreased During Atherosclerosis Regression and Is Increased in Urinary Extracellular Vesicles During Atherosclerosis Progression'. Frontiers In Immunology, 11 

Platelet Hyperactivation in Multiple Myeloma Is Also Evident in Patients with Premalignant Monoclonal Gammopathy of Undetermined Significance.

Leanne R O'Sullivan, Gerardene Meade-Murphy, Oonagh M Gilligan, Vitaliy Mykytiv, Paul W Young, Mary R Cahill. British Journal of Haematology, 01 Jun 2020, doi: 10.1111/bjh.16774. (Online ahead of print) 

Development of Dynamic Cell and Organotypic Skin Models, for the Investigation of a Novel Viscoelastic Burns Treatment Using Molecular and Cellular Approaches.

Robert G. Wallace, Mary-Rose Kenealy, Aidan J. Brady, Emer Duffy, Bernard Degryse, Gerardene Meade-Murphy, Marc-Antoine Custaud, Aoife Morrin, Ronan P. Murphy. Burns (Journal of the International Society for Burns Injuries). On line 14 May 2020, 

Investigating mitochondrial dysfunction in gestational diabetes mellitus and elucidating if BMI is a causative mediator.

McElwain C, McCarthy CM. Eur J Obstet Gynecol Reprod Biol. 2020;251:60-5.

Don't judge too RAShly: the multifaceted role of the renin-angiotensin system and its therapeutic potential in COVID-19. 

Walther T, Kuebler WM.

Am J Physiol Lung Cell Mol Physiol. 2020. 318(5):L1023-L1024.

Short-term Western Diet aggravates Non-Alcoholic Fatty Liver Disease (NAFLD) With Portal Hypertension in TGR(mREN2)27 Rats

Cremonese C, Schierwagen R, Uschner FE, Torres S, Tyc O, Ortiz C, Schulz M, Queck A, Kristiansen G, Bader M, Sauerbruch T, Weiskirchen R, Walther T, Trebicka J, Klein S.

 Int J Mol Sciences 2020. 21: 3308 (1-14).

The virtually mature B-type natriuretic peptide (BNP1-32) is a precursor for the more effective BNP1-30

Schwiebs, A;Wang, Y;Moore, AM;Zhu, XD;Pankow, K;Siems, WE;Walther, T

(2020)  British Journal of Pharmacology

Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease.

Kaya E, Smith DA, Smith C, Boland B, Strupp M, Platt FM.

J Clin Med. 2020 Apr 8;9(4). pii: E1050. doi: 10.3390/jcm9041050.

PMID: 32276303 [PubMed - as supplied by publisher]

Effect of L-Ergothioneine on the metabolic plasma profile of the RUPP rat model of pre-eclampsia.

Morillon AC, Williamson RD, Baker PN, Kell DB, Kenny LC, English JA, McCarthy FP, McCarthy C.

PLoS One. 2020 Mar 31;15(3):e0230977. doi: 10.1371/journal.pone.0230977. eCollection 2020.

The effect of sphingosine‐1‐phosphate on the endothelial glycocalyx during ischemia‐reperfusion injury in the isolated rat heart.

Hala Araibi, Elizabeth van der Merwe, Asfree Gwanyanya, Roisin Kelly‐Laubscher

First published:03 February 2020 / https://doi.org/10.1111/micc.12612

The Biology of Ergothioneine, an antioxidant nutraceutical.

Borodina I, Kenny LC, McCarthy CM, Paramasivan K, Pretorius E, Roberts TJ, van der Hoek SA, Kell DB.

Nutr Res Rev. 2020 Feb 13:1-28. doi: 10.1017/S0954422419000301

The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2

Shailendra Anoopkumar-Dukie, Tom Conere, Aileen Houston, Liam King, David Christie, Catherine McDermott, Ashley Allshire

Reference:  Prostaglandins & Other Lipid Mediators (2020) 148:106422

L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model.

Williamson RD, McCarthy FP, Manna S, Groarke E, Kell DB, Kenny LC, McCarthy CM.

Hypertension.  2020 Feb;75(2):561-568. doi: 10.1161/HYPERTENSIONAHA.119.13929.

2019 Publications

Immunomodulatory therapeutic strategies in stroke

Malone, K., Amu, S., Moore, A.C. & Waeber, C. 2019, "Immunomodulatory therapeutic strategies in stroke", Frontiers in pharmacology, vol. 10, pp. 630-630.

The immune system and stroke: from current targets to future therapy

Malone, K., Amu, S., Moore, A.C. & Waeber, C. 2019, "The immune system and stroke: from current targets to future therapy", Immunology and cell biology, vol. 97, no. 1, pp. 5-16.

The virtually mature B‐type natriuretic peptide (BNP1‐32) is a precursor for the more effective BNP1‐30

Anja Schwiebs, Yong Wang, Andrew M. Moore, Xudong Zhu, Kristin Pankow, Wolf‐Eberhard Siems, Thomas Walther

First published:06 November 2019 / https://doi.org/10.1111/bph.14890

TGR(mREN2)27 rats develop non-alcoholic fatty liver disease-associated portal hypertension responsive to modulations of Janus-kinase 2 and Mas receptor

Sabine Klein, Carola-Ellen Kleine, Andrea Pieper, Michaela Granzow, Sebastian Gautsch, Mimoun Himmit, Katharina Kahrmann, Robert Schierwagen, Frank Erhard Uschner, Fernando Magdaleno, Maria Eleni Naoum, Glen Kristiansen, Thomas Walther, Michael Bader, Tilman Sauerbruch and Jonel Trebicka 

Scientific Reports volume 9, Article number:  11598 (2019)

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells.

Alshangiti AM, Tuboly E, Hegarty SV, McCarthy CM, Sullivan AM, O'Keeffe GW

Oxid Med Cell Longev. 2019 Dec 5;2019:1670759. doi: 10.1155/2019/1670759

GHSR-1 agonist sensitizes rat colonic intrinsic and extrinsic neurons to exendin-4: A role in the manifestation of postprandial gastrointestinal symptoms in irritable bowel syndrome?

Buckley MM, O'Brien R, Buckley JM, O'Malley D.

Neurogastroenterol Motil. 2019 Jul 16:e13684. doi: 10.1111/nmo.13684.

Polyethylene microplastics adhere to Lemna minor (L.), yet have no effects on plant growth or feeding by Gammarus duebeni(Lillj.)

Alicia Mateos-Cárdenas a,c,⁎, David T. Scott a,c, Gulzara Seitmaganbetova a,c, Frank N.A.M. van Pelt b,c,
John O'Halloran a,c, Marcel A.K. Jansen a,c

• a. School of Biological, Earth and Environmental Sciences, University College Cork, North Mall, Cork City, Ireland
• b. Department of Pharmacology and Therapeutics, Western Gateway Building, University College Cork,Western Road, Cork City, Ireland
• c. Environmental Research Institute, Lee Road, Cork City, Ireland

Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study. Ann Intensive Care

Schouten LR, van Kaam AH, Kohse F, Veltkamp F, Bos LD, de Beer FM, van Hooijdonk RT, Horn J, Straat M, Witteveen E, Glas GJ, Wieske L, van Vught LA, Wiewel MA, Ingelse SA, Cortjens B, van Woensel JB, Bos AP, Walther T, Schultz MJ, Wösten-van Asperen RM; MARS consortium

2019. 9:55 (1-9)

Building a supportive framework for brain research in Ireland: Inaugural position paper of the Irish Brain Council

Rogers M, Boland B, Clarke S, Craven A, Fassbender C, Gill M, Hardiman O, Henshall DC, Lynch T, Mitchell K, Pender N, Rogan C, Roche RAP. Eur J Neurosci

2019 Jan 23;. doi: 10.1111/ejn.14351. [Epub ahead of print] PubMed PMID: 30673123 

PI 3-kinase- and ERK-MAPK-dependent mechanisms underlie Glucagon-Like Peptide-1-mediated activation of Sprague Dawley colonic myenteric neurons

O'Brien R, Buckley MM, Kelliher A, O'Malley D

Neurogastroenterol Motil. 2019 May 23:e13631. doi: 10.1111/nmo.13631

PMID:

Heparan sulphate and hylauronic acid components of the glycocalyx do not play a role in flow mediated dilation of the iliac in the anaesthetized pig

Ruane-O'Hora T, O'Malley D, Buckley MM, Markos F

Can J Physiol Pharmacol. 2019 May 14. doi: 10.1139/cjpp-2019-0124

Activation of a TLR9 mediated innate immune response in preeclampsia

Williamson RD, McCarthy FP, Kenny LC, McCarthy CM

Sci Rep. 2019 Apr 11;9(1):5920

Placental Ageing in Adverse Pregnancy Outcomes: Telomere Shortening, Cell Senescence, and Mitochondrial Dysfunction

Manna S, McCarthy CM, McCarthy FP. Oxidative Medicine and Cellular Longevity 2019 June Vol. 2019, Article ID 3095383

2018 Publications

The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation

Sheng, R., Song, D., Zhang, T., Chen, J., Xia, Y., Qin, Z. & Waeber, C. 2018, "The role and mechanisms of sphingosine kinase 2 in cerebral preconditioning-induced autophagy activation", Proceedings for Annual Meeting of The Japanese Pharmacological Society, vol. WCP2018, pp. PO4-1-27.

Platelets - From Formation to Function (Book chapter).

Twomey L, Wallace RG, Cummins PM, Degryse B, Sheridan S, Harrison M, Moyna N, Meade-Murphy G, Navasiolava N, Custaud M-A, Murphy RP.   In Homeostasis - An Integrated Vision. Publisher: InTechOpen; Pub. Date: 2018. ISBN: 978-953-51-6117-2. 

Platelets - Functional Biomarkers of Epigenetic Drift (Book chapter).

Twomey L, Wallace RG, Mangone M, Degryse B, Sheridan S, Harrison M, Moyna M, Meade-Murphy G, Nastassia Navasiolava N, Custaud M-A, Murphy RP. In Homeostasis - An Integrated Vision. Publisher: InTechOpen; Pub. Date: 2018. ISBN: 978-953-51-6117-2.

Platelet Analysis (Patent).

Lourdes Basabe-Desmonts, Sofia Ramstrom, Antonio Ricco, Kenny Dermot, Gerardene Meade, Sarah O'neill, Asif Riaz, Luke Lee. Patent office: US; Publication date: 2018/4/10; Patent no: 9939430; Application no. 13123411.

Data on the regulation of moesin and merlin by urokinase: Model explaining distal activation of integrins by the uPAR.

Degryse B, Britto M, Shan CX, Wallace RG, Rochfort KD, Cummins PM, Meade G, Murphy RP. Int J Biochem Cell Biol. Vol. 15, December 2017, Pages 600-605. https://doi.org/10.1016/j.dib.2017.10.023

Neprilysin degrades murine Amyloid-β (Aβ) more efficiently than human Aβ: Further implication for species-specific amyloid accumulation. Neuroscience Letters

Becker M, Moore A, Naughton M, Boland B, Siems WE, Walther T 2018 Nov 1;686:74-79

Consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with RAAS-inhibitors - Coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology

Rosano GMC, Tamargo J, Lainscak M, Agewall S, Anker AD, Ceconi C, Coats AJS, Drexler H, Gerasimos Filippatos G, Kaski JC, Kjeldsen K, Lund L, Niessner A, Savarese, G, Schmidt TA, Seferovic P, Wassmann S, Walther T, Lewis BS. Eur Heart J Cardiovasc Pharmacother. 2018. 4:180-188.

Decarboxylation of Ang-(1-7) to Ala1-Ang-(1-7) leads to significant changes in pharmacodynamics

Tetzner A, Naughton M, Gebolys K, Eichhorst J, Sala E, Villacañas O, Walther T

Eur J Pharmacol. 2018. 833:116-123.

Non-insulin Antidiabetic Pharmacotherapy in Patients with Established Cardiovascular Disease: a Position Paper of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy

Niessner A, Tamargo J, Koller L, Saely CH, Schmidt TA, Savarese G, Wassmann S, Rosano G, Ceconi C, Torp-Pedersen C, Kaski JC, Kjeldsen KP, Agewall S, Walther T, Drexel H, Lewis BS ,Eur Heart J. 2018.

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing. Nat Rev Drug Discov

Boland B, Yu WH, Corti O, Mollereau B, Henriques A, Bezard E, Pastores GM, Rubinsztein DC, Nixon RA, Duchen MR, Mallucci GR, Kroemer G, Levine B, Eskelinen EL, Mochel F, Spedding M, Louis C, Martin OR, Millan MJ 2018 Sep;17(9):660-688. 

No evidence in support of a prodromal respiratory control signature in the TgF344-AD rat model of Alzheimer's disease.Respir Physiol Neurobiol

Lucking EF, Murphy KH, Burns DP, Jaisimha AV, Barry-Murphy KJ, Dhaliwal P, Boland B, Rae MG, O'Halloran KD

2018 Jun 30.

Wood ash residue causes a mixture of growth promotion and toxicity in Lemna Minor

Jagodzinski LS, O’Donoghue MT, Heffernan LB, van Pelt FNAM, O’Halloran J, Jansen MAK.

Science of the Total Environment 625 (2018) 667-676

Development of an ex Vivo Method for Multi-unit Recording of Microbiota-Colonic-Neural Signaling in Real Time

Buckley MM, O'Malley D , Front Neurosci. 2018 Feb 27.

A perspective on pre-eclampsia and neurodevelopmental outcomes in the offspring: Does maternal inflammation play a role?

Maher GM, McCarthy FP, McCarthy CM, Kenny LC, Kearney PM, Khashan AS, O'Keeffe GW.

Int J Dev Neurosci. 2018 Nov 2. 

Exploring the role of mitochondrial dysfunction in the pathophysiology of pre-eclampsia. Pregnancy Hypertension

Williamson RD, McCarthy FP, Khashan A, Totorika A, Kenny LC, McCarthy C

2018 Jul;13:248-253. doi: 10.1016/j.preghy.2018.06.012

Biomarkers of Glomerular Dysfunction in Pre-eclampsia - A Systematic Review. Pregnancy Hypertension

Kerley RN, McCarthy C.

2018; S2210-7789(17)30494-4

The potential therapeutic effects of L-ergothioneine in Pre-eclampsia. Free Radical Biology and Medicine

Kerley RN, McCarthy C, Kell DB, Kenny LC

2018 Mar; 117:145-157

Platelets: From Formation to Function

Twomey L, Wallace RG, Cummins PM, Bernard Degryse B, Sheridan S, Harrison M, Moyna N, Meade-Murphy G, Navasiolava N, Custaud MA, Murphy RP. Homeostasis: An Integrated Vision. Publisher: IntechOpen; Editors, Fernanda Lasakosvitsch F and Garnes SDA. Book chapter 5, 71-92, Dec 31st, 2018

Platelets: Functional Biomarkers of Epigenetic Drift

Twomey L, Wallace RG, Mangone M, Degryse B, Sheridan S, Harrison M, Moyna N, Meade-Murphy G, Navasiolava N, Custaud MA, Murphy RP. Homeostasis: An Integrated Vision. Publisher: IntechOpen; Editors, Lasakosvitsch F, Garnes SDA. Book Chapter 6, 93-120, Dec 31st, 2018

Platelet Analysis. Basabe-Desmonts

L, Ramstrom S, Ricco AJ, Kenny D, Meade G, O'Neill S, Riaz A, Lee L. Patent no: 9939430: Application no: 13123411. Publication Date: 10-04-2018

2017 Publications

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Song, D., Zhang, T., Chen, J., Xia, Y., Qin, Z., Waeber, C. & Sheng, R. 2017, "Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain", Cell death & disease, vol. 8, no. 7, pp. e2912-e2912.

Cerebral Blood Flow Methods

C.Waeber , Primer on Cerebrovascular Diseases (Second Edition), 2017, Pages 324-327.
 

Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair

 Sartawi, Z., Schipani, E., Ryan, K.B. & Waeber, C. 2017, "Sphingosine 1-phosphate (S1P) signalling: Role in bone biology and potential therapeutic target for bone repair", Pharmacological research, vol. 125, no. Pt B, pp. 232-245.

Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR.

Degryse B, Britto M, Shan CX, Wallace RG, Rochfort KD, Cummins P, Meade G, Murphy RP. Data in Brief, 15, p 600-605, 2017.

Non-insulin antidiabetic pharmacotherapy in patients with established cardiovascular disease

Niessner A, Tamargo J, Koller L, Saely CH, Schmidt TA, Savarese G, Wassmann S, Rosano G, Ceconi C, Torp-Pedersen C, Kaski JC, Kjeldsen KP, Agewall S, Walther T, Drexel H, Lewis BS.

A position paper of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. Eur Heart J. 2017

Angiotensin-(1-7) counteracts the transforming effects triggered by angiotensin II in breast cancer cells

Cambados N, Walther T, Nahmod K, Tocci JM, Rubinstein N, Simian M, Sampayo R, Böhme I, Del Valle Suberbordes M, Kordon EC, Schere-Levy C. 

Oncotarget. 2017. 8: 88475-88487

Acceptability of microneedle-patch vaccines: A qualitative analysis of the opinions of parents.

Marshall, S, Fleming, A, Moore AC, Sahm LJ. Vaccine (2017), Aug 2. pii: 20264-410X(17)31009-5.

Comprehensive efforts to increase adherence to statin therapy

Vonbank A, Agewall S, Kjeldsen KP, Lewis BS, Torp-Pedersen C, Ceconi C, Funck-Brentano C, Kaski JC, Niessner A, Tamargo J, Walther T, Wassman S, Rosano G, Schmidt H, Saely CH, Drexel H. European Society of Cardiologists Working Group Position Paper

Eur Heart J. 2017. 38: 2473-2479. 

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Dan-Dan Song, Tong-Tong Zhang, Jia-Li Chen, Yun-Fei Xia, Zheng-Hong Qin, Christian Waeber, Rui Sheng.

Cell Death and Disease (2017) 8, e2912

Moesin and Merlin Regulate Urokinase Receptor-Dependent Endothelial Cell Migration, Adhesion and Angiogenesis

Degryse B, Britto M, Shan CX, Cummins P, Meade G, Murphy RP. 

The International Journal of Biochemistry & Cell Biology, (2017) Jul;88:14-22.

Gender differences in the effects of cardiovascular drugs

Tamargo J, Rosano G, Walther T, Duarte J, Niessner A, Kaski JC, Cecconi C, Drexel H, Kjeldsen K, Savarese G, Torp-Petersen C, Atar D, Lewis BS, Agewall S.

Eur Heart J Cardiovasc Pharmacotherapy. 2017 3:163-182

Mas receptor is involved in the estrogen-receptor induced nitric oxide-dependent vasorelaxation

Sobrino A, Vallejo s, Novella S, Lázaro-Franco M, Mompeón A, Bueno-Betí C, Walther T, Sánchez Ferrer C, Pieró C, Hermenegildo C.

Biochem Pharmacol (2017), Apr, 129:67-72

Further intracellular proteins and signaling pathways regulated by angiotensin-(1-7) in human endothelial cells

Meinert C, Kohse F, Boehme I, Gembardt F, Tetzner A, Wieland T, Greenberg B, Walther T.

Data in Brief (2017), February, 10:354–363

2016 Publications

Münzner M, Tappenbeck N, Gembardt F, Rülke R, Furkert J, Melzig MF, Siems WE, Brockmann GA, Walther T. (2016)

Green Tea reduces body fat via upregulation of neprilysin

International Journal of Obesity (2005), (40): 1850-1855

Schouten LR, Helmerhorst HJ, Wagenaar GT, Haltenhof T, Lutter R, Roelofs JJ, van Woensel JB, van Kaam AH, Bos AP, Schultz MJ, Walther T, Wösten-van Asperen RM. (2016)

Age-dependent changes in the Pulmonary Renin-Angiotensin System are associated with severity of lung injury in a model of acute lung injury in rats

Critical Care Medicine, (44); e1226-e1235

Sahr A, Wolke C, Maczewsky J, Krippeit-Drews P, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, dombrowski F, Walter T, Lendeckel U. (2016)

The Angiotensin-(1-7)/Mas axis improves pancreatic β-cell function in vitro and in vivo

Endocrinology, (157): 4677-4690

Gallego-Delgado J, Walther T, Rodriquez A. (2016)

The High Blood Pressure-Malaria Protection Hypothesis

Circulation Research, (119): 1046-1048

Auer-Grumbach M, Toegel S, Schabhüttl M, Weinmann D, Chiari C, Bennett DL, Beetz C, Klein D, Andersen PM, Böhme I, Fink-Puches R, Gonzalez M, Harms MB, Motley W, Reilly MM, Renner W, Rudnik-Schöneborn S, Schlotter-Weigel B, Themistocleous AC, Weishaupt JH, Ludolph AC, Wieland T, Tao F, Abreu L, Windhager R, Zitzelsberger M, Strom TM, Walther T, Scherer SS, Züchner S, Martini R, Senderek J. (2016)

Rare variants in MME, encoding metalloprotease neprilysin are linked to late-onset autosomal-dominant axonal polyneuropathies

American Journal of Human Genetics, (99): 607-623

Gallego-Delgado J, Basu-Roy U, Ty M, Alique M, Fernandez-Arias C, Movila A, Gomes P, Weinstock A, Xu W, Edagha I, Wassmer SC, Walther T, Ruiz-Ortega M, Rodriguez A. (2016)

Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria

Journal of Clinical Investigation, (126): 4016-4029

Tetzner A, Gebolys K, Meinert C, Klein S, Uhlich A, Trebicka J, Villacañas O, Walther T. (2016)

G-Protein-Coupled Receptor MrgD is a receptor for Angiotensin-(1-7) involving Adenylyl Cyclase, cAMP, and Phosphokinase A

Journal of Hypertension, 68: 185-194.

Marshall, S, Sahm, LJ, Moore, AC.

The success of microneedle-mediated vaccine delivery into skin

Human Vaccines & Immunotherapeutics (2016) DOI: 10.1080/21645515.2016.1171440

Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, EL Amki M, Fatar M, Carcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D.

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis.

Stroke. 2016 May; 47 (5): 1312-8. 

Khan A, Wang Y, Schultheiss HP, Moreira Mda C, Walther T.

Role of monokine induced by interferon-gamma (MIG) in discrimation and pronosis of patients with Chagas' disease and idiopathic dilated cardiomyopathy.

J Cardiovasc Pharmacol. 2016. May; 67(5):427-32.

Supé S, Kohse F, Gembardt F, Kuebler WM, Walther T.

Therapeutic time window for angiotensin-(1-7) in acute lung injury.

 Br J Pharmacol. 2016. May; 173 (10): 1618-28.

Houston A, Williams JM, Rovis TL, Shanley DK, O'Riordan RT, Kiely PA, Ball M, Barry OP, Kelly J, Fanning A, Mac Sharry J, Mandelboim O, Singer BB, Jonjic S, Moore T.

Pregnancy-specific glycoprotein expression in normal gastrointestinal tract and in tumors detected with novel monoclonal antibodies.

MAbs. 2016 Apr; 8 (3): 491-500.

Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžić S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH.

CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation

J Cereb Blood Flow Metab. 2016 Apr; 36 (4): 781-93 PMID: 26661156.

Vrdoljak A, Allen EA, Ferrara F, Temperton NJ, Crean AM, Moore AC.

Induction of Broad Immunity by Thermostabilised Vaccines Incorporated in Dissolvable Microneedles Using Novel Fabrication Methods  

 J Control Release. 2016 Mar 10; 225: 192-204. 

Allen EA, O'Mahony C, Cronin M, O'Mahony T, Moore AC, Crean AM. 

Dissolvable Microneedle Fabrication using Piezoelectric Dispensing Technology

The International Journal of Pharmaceutics. 2016 Mar 16; 500 (1-2):1-10.

Marshall S., Sahm L., Moore A.C.

Microneedle technology for immunisation: perception, acceptability and suitability for paediatric use

Vaccine, 2016 Feb 3: 34(6): 723-34 PMID: 26706274.

Klionsky DJ, 2211 authors, Waeber C, and … 253 more authors.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Autophagy 2016 Jan 2; 12 (1):1-222.

Meinert C, Gembardt F, Boehme I, Wieland T, Greenberg B, Walther T.

Identification of intracellular proteins and signaling pathways in human endothelial cells regulated by angiotensin-(1-7)

J Proteomics. 2016 Jan 1; 130:129-139.

Shiely F,Fallon D, Casey C, Kerins DM, Eustace JA.

Trial of a novel plasma gas disinfection system (Radica) to reduce mattress residual bacterial contamination in the acute hospital setting: a preliminary study.

Irish Journal of Medical Science 2016 Jan 21. [Epub ahead of print]

Waeber C

(2016) Cerebral blood flow methods, in "Primer on Cerebrovascular Diseases", Second Edition

Louis R. Caplan, Jose Biller, Megan Leary, Ajith Thomas, Eng Lo, Midori Yenari, and John Zhang eds., Elsevier.

2015 Publications

Wong LH, Ting P, Kerins D.

Seasonal variations in nocturnal changes in blood pressure between Ireland and Singapore

Clin Trials Regul Sci Cardiol. 2015 Dec;12:12-17.

McCarthy, M, Bane, V, García Altares Pérezc, M, van Pelt, FNAM, Furey, A, O'Halloran J.

Assessment of emerging biotoxins (Pinnatoxin G and Spirolides) at Europe's first marine reserve: Lough Hyne 

Toxicon 2015 Dec; 108: 202-209

Breitling S, Krauszman A, Parihar R, Walther T, Friedberg MK, Kuebler MW.

Dose-dependent, therapeutic potential of angiotensin-(1-7) for the treatment of pulmonary arterial hypertension

Pulmonary Circ. 2015 Dec: 5 (4):649-657.

O' Callaghan C, Fanning LJ, Barry OP.

Hypermethylation of MAPK13 Promoter in Oesophageal Squamous Cell Carcinoma Is Associated with Loss of p38δ MAPK Expression

Cancers (Basel). 2015 Oct 23;7(4):2124-33. PMID: 26512696

Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP.

Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders

Front Cell Neurosci. 2015 Oct 14;9:392. Review. PMID: 26528128

Golubeva AV, Crampton S, Desbonnet L, Edge D, O'Sullivan O, Lomasney KW, Zhdanov AV, Crispie F, Moloney RD, Borre YE, Cotter PD, Hyland NP, O'Halloran KD, Dinan TG, O'Keeffe GW, Cryan JF.

Prenatal stress-induced alterations in major physiological systems correlate with gut microbiota composition in adulthood.

Psychoneuroendocrinology 2015 Oct;60:58-74. PMID: 26135201

Kumar R, Kerins DM, Walther T.

Cardiovascular Safety of Antidiabetic Drugs

Eur Heart J CVP. 2015.

Klein S, Herath CB, Schierwagen R, Grace J, Haltenhof T, Uschner FE, Strassburg CP, Sauerbruch T, Walther T, Angus PW, and Trebicka J.

Hemodynamic effects of the non-peptidic angiotensin-(1-7) agonist AVE0991 in liver cirrhosis

PLoS One, 2015 Sep 25: 10 (9): 1-14.

Alenina N, Boehme I, Bader M, Walther T.

Multiple non-coding exons and alternative splicing in the mouse Mas protooncogene

Gene. 2015 Sep 1: 568 (2):155-64.

Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM.

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers

JBiol Chem. 2015 Jul 3;290(27):16502-16.

Pearson FE, O'Mahony C, Moore AC, Hill AV.  

Induction of CD8+ T cell responses and protective efficacy following microneedle-mediated delivery of a live adenovirus vectored malaria vaccine.    

Vaccine.  (2015)  Jun 22;33(28):3248-55.

Boland B, Platt FM.

Bridging the age spectrum of neurodegenerative storage diseases 

Best Practice and Research: Clinical Endocrinology and Metabolism 2015 Mar; 29(2): 127-143

Barry OP, O'Sullivan E, and McCarthy M.

Periodic review sessions contribute to student learning across the disciplines in pharmacology

M. Journal of The Scholarship of Teaching and Learning. 2015 Feb; 15 (1): 38-56

O'Callaghan C, Fanning LJ, Barry OP.

p38δ MAPK phenotype: an indicator of chemotherapeutic response in oesophageal squamous cell carcinoma

Anticancer Drugs. 2015 Jan;26(1):46-55.  PMID: 25099621

Barry OP, O’ Sullivan E, McCarthy M.

One size does not fit all in the assessment of pharmacology learning in a diverse multidisciplinary undergraduate student class

Int J Basic Clin Pharmacol. 2015; 4(6): 1281-1289

Hyland NP, O'Mahony SM, O'Malley D, O'Mahony CM, Dinan TG, Cryan JF.

Early-life stress selectively affects gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction

Neurogastroenterol Motil. 2015 Jan;27(1):105-13. PMID: 25443141

2014 Publications

Clarke SF, Murphy EF, O’Sullivan O, Lucey AJ, Humphreys M, Horgan A, Hayes P, O’Reilly M, Jeffery IB, Wood-Martin R, Kerins DM, Quigley E, Ross RP, O’Toole PW, Molly MG, Falvey E, Shanahan F, Cotter PD.

Exercise and associated dietary extremes impact on gut microbial diversity

Gut. 2014 Dec;63(12):1913-20.

McCarthy M, O'Halloran J, O'Brien NM, van Pelt FN

Does the marine biotoxin okadaic acid cause DNA fragmentation in the blue mussel and the pacific oyster?

Marine Environmental Research 2014 Oct; 101:153-160.

McCarthy M, van Pelt FNAM, Bane V, O'Halloran J Furey A.

Application of passive (SPATT) and active sampling methods in the profiling and monitoring of marine biotoxins

Toxicon, 2014 Oct; 89 :77-86.

O'Callaghan C, Fanning LJ, Barry OP.

p38δ MAPK: Emerging Roles of a Neglected Isoform

Int J Cell Biol. 2014;2014:272689. PMID: 25313309

O'Mahony SM, Felice VD, Nally K, Savignac HM, Claesson MJ, Scully P, Woznicki J, Hyland NP, Shanahan F, Quigley EM, Marchesi JR, O'Toole PW, Dinan TG, Cryan JF.

Disturbance of the gut microbiota in early-life selectively affects visceral pain in adulthood without impacting cognitive or anxiety-related behaviors in male rats

Neuroscience. 2014 Sep 26;277:885-901. PMID: 25088912

Paleco R, Vučen SR, Crean AM, Moore AC, Scalia S*.

Enhancement of the in vitro penetration of quercetin through pig skin by combined microneedles and lipid microparticles

International Journal of Pharmaceutics 2014 Sep 10; 472(1-2): 206-13.

Carey JB, Vrdoljak A, O'Mahony C, Hill AV, Draper SJ, Moore AC.

Microneedle-mediated immunization of an adenovirus-based malaria vaccine enhances antigen-specific antibody immunity and reduces anti-vector responses compared to the intradermal route

Nature Scientific Reports. 2014 Aug 21;4:6154.

Hyland NP, Quigley EM, Brint EK.

Microbiota-host interactions in irritable bowel syndrome: epithelial barrier, immune regulation and brain-gut interactions

World J Gastroenterol. 2014 Jul 21;20(27):8859-66. PMID:  25083059

Lomasney KW, Cryan JF, Hyland NP.

Converging effects of a Bifidobacterium and Lactobacillus probiotic strain on mouse intestinal physiology

Am J Physiol Gastrointest Liver Physiol. 2014 Jul 15;307(2):G241-7.  PMID:  24852567

Sheng R, Zhang TT, Felice VD, Qin T, Qin ZH, Smith CD, Sapp E, Difiglia M, Waeber C.

Preconditioning stimuli induce autophagy via sphingosine kinase 2 in mouse cortical neurons

J Biol Chem. 2014 Jul 25; 289(30):20845-57.PMID: 24928515

Lomasney KW, Houston A, Shanahan F, Dinan TG, Cryan JF, Hyland NP.

Selective influence of host microbiota on cAMP-mediated ion transport in mouse colon.

Neurogastroenterol Motil. 2014 Jun; 26(6): 887-90.

Wang Y, Moreira Mda C, Heringer-Walther S, Schultheiss HP, Siems W, Wessel N, Walther T.

Beta blockers prevent correlation of plasma ACE2 activity with echocardiographic parameters in patients with idiopathic dilated cardiomyopathy

J Cardiovasc Pharmacol. 2014 June; 26(6). 887-90

Blasi F, Wei Y, Balkaya M, Tikka S, Mandeville JB, Waeber C, Ayata C, Moskowitz MA.

Recognition memory impairments after subcortical white matter stroke in mice

Stroke. 2014 May; 45(5):1468-73 PMID: 24723319

Phelan M, Khaldi N, Shields DC, Kerins DM.

Angiotensin converting enzyme and nitric oxide inhibitory activities of novel milk derived peptides

International Dairy Journal 2014 Mar; 35(1):38–42

Waeber C, Walther T.

Sphingosine-1-phosphate as a potential target for the treatment of myocardial infarction

Circ J. 2014; 78 (4):795-802.

Hyland NP, Golubeva AV.

GABA_B receptors in the bladder and bowel: Therapeutic potential for positive allosteric modulators?

Br J Pharmacol. 2014 Feb 12.

McGrath MG, Vrdoljak A, O'Mahony C, Crean AM, Moore AC.

Production of Dissolvable Microneedles using an Atomized Spray Process: Effect of Microneedle Composition on Skin Penetration 

European Journal of Pharmaceutics and Biopharmaceutics. 2014Feb;86(2):200-11.

Walther T, Voss A, Baumert M, Truebner S, Till H, Stepan H, Wessel N, Faber R.

Cardiovascular variability before and after accouchement: recovery from arterial stiffness in women with preeclampsia 4 days after delivery  

Hypertens Pregnancy. 2014. 33:1-14.

Freund M, Walther T, von Bohlen und Halbach O.

Effects of the angiotensin-(1-7) receptor Mas on cell proliferation and on the population of doublecortin positive cells within the dentate gyrus and the piriform cortex

Eur Neuropsychopharm. 2014. 24:302-308.

O’Caoimh R, Healy L, Gao Y, Svendrovski A, Kerins DM, Eustace J, Kehoe PG, Guyatt G, Molloy DW.

Effects of centrally acting angiotensin converting enzyme inhibitors on functional decline in patients with alzheimer's disease J Alzheimers Dis. 2014;40(3):595-603.

Dauphard J, Lehane M, van Pelt F, O'Halloran J, and Furey A.

Anatoxin: Chemistry, Effects, Source, Metabolism, and Detection.

Seafood and Freshwater Toxins: Pharmacology, Physiology and Detection (2014), 3^rd ed. (CRC Press), p 1061-1072.

2013 Publications

Carroll SY, O'Mahony SM, Grenham S, Cryan JF, Hyland NP.

Disodium cromoglycate reverses colonic visceral hypersensitivity and influences colonic ion transport in a stress-sensitive rat strain.

PLoS One. 2013 Dec 18;8(12)

Klein N, Gembardt F, Supé S, Kaestle SM, Nickles H_, Erfinanda L, Lei X, Yin J, Wang L, Mertens M, Szaszi K, Walther T*, Kuebler WM.

Angiotensin-(1-7) protects from experimental acute lung injury.

Crit Care Med. 2013. 41:334-343. * Corresponding author and equally contributing last author 

Ramirez Avila GM, Gapelyuk A, Marwan N, Stepan H, Kurths J, Walther T, Wessel N.

Classifying Healthy Women and Preeclamptic Patients from Cardiovascular Data Using Recurrence and Complex Network Methods.

 Auton Neurosci. 2013. 178:103-110.

Vučen SR, Vuleta G, Crean AM, Moore AC, Ignjatović N, Uskoković D.

Improved percutaneous delivery of ketoprofen using combined application of nanocarriers and silicon microneedles.

2013 J. Pharm. Pharmacol. (2013) Oct;65 (10):1451-62.

Grace JA, Klein S, Herath CB, Granzow M, Schierwagen R, Masing N, Walther T, Sauerbruch T, Burrell LM, Angus PW, Trebicka J.

The Angiotensin-(1-7)/Mas-receptor axis of the renin-angiotensin system mediates mesenteric vasodilation in cirrhosis.

Gastroenterology. 2013. 145:874-884.

O'Callaghan C, Fanning LJ, Houston A, Barry OP.

Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.

Int J Oncol. 2013 Aug;43(2):405-15.

Ramirez Avila GM, Gapelyuk A, Marwan N, Walther T, Stepan H, Kurths J, Wessel N.

Classification of cardiovascular time series based on different coupling structures using recurrence networks analysis.

Philosophical Transactions A. 2013. 371:20110623.

Gao Y, O’Caoimh R, Healy L, Kerins DM, Eustace J, Guyatt G, Sammon D, Molloy DW.

Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia.

BMJ Open Volume 3, Issue 7, 2013

Smith MT_,Woodruff TM, Wyse BD, Muralidharan A, WaltherT.

A small molecule angiotensin II type 2 receptor (AT2R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.

Pain Med. 2013. 14:1557-1568.

Lucitt MB, O’Brien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, Kent N, Ricco AJ, Kenny D. 

Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion.

Annals of Bioanalytical Chemistry, 2013 May;405(14):4823-34.

Peiró C, Vallejo S, Gembardt F, Palacios E, Azcutia V, Rodríguez-Mañas L, Sánchez-Ferrer CF, Walther T.

Complete blockade of the vasorelaxant effects of Ang-(1-7) and bradykinin in murine microvessels by agonists of the receptor Mas.

J Physiol. 2013. 591:2275-2285. 

Wang Y, Khan A, Heringer-Walther S, Schultheiss HP, Moreira Mda C, Walther T.

Prognostic value of circulating levels of stem cell growth factor beta (SCGF beta) in patients with Chagas' disease and idiopathic dilated cardiomyopathy.

Cytokine. 2013. 61:728-31.  

Lambe T, Carey JB, Li Y, Spencer AJ, van Laarhoven A, Mullarkey CE, Vrdoljak A, Moore AC, Gilbert SC.

Immunity Against Heterosubtypic Influenza Virus Induced By Adenovirus And MVA Expressing Nucleoprotein And Matrix Protein-1

Nature Scientific Reports. (2013). 3: 1443.

Rossitto G, Regolisti G, Rossi E, Negro A, Nicoli D, Casali B, Toniato A, Caroccia B, Seccia TM, Walther T, Rossi GP.

Elevation of AT1-Receptor Autoantibodies Titer In Primary Aldosteronism Due To Aldosterone-Producing Adenoma.

Hypertension. 2013. 61:526-33.

Zhu X, Wang Y, Schwiebs A, Walther T.

Chimeric natriuretic peptide ACNP stimulates both natriuretic peptide receptors, the NPRA and NPRB.

Mol Cell Endocrinol. 2013. 366:117-123.

Kerins DM, Vaughan C.

Murmurs, heart sounds and more

Book Chapter: Learning clinical skills: Pearls, pitfalls and tips for the OSCE Ed Maher B, Henn P.

2014 Elsevier B.V.

Goodman AL, Forbes EK, Williams AR, Douglas AD, de Cassan SC, Bauza K, Biswas S, Dicks MDJ, Llewellyn D, Moore AC, Janse CJ, Franke-Fayard BM, Gilbert SC, Hill AVS, Pleass RJ, Draper SJ.

The utility of Plasmodium berghei as a rodent model for anti-merozoite malaria vaccine assessment

Nature Scientific Reports. (2013) 1706.