TRAP Funding

Translational Research Access Programme

IMPORTANT NOTICE TO POTENTIAL TRAP APPLICANTS 2019

TRAP applicants should appraise themselves of the application timeframes and associated approval timeframes for those projects that require CREC approval https://www.ucc.ie/en/crec/.

APPLICATIONS PROCESS IS NOW CLOSED.

TRAP 2019 will be the ninth-year that funding has been made available through the School of Medicine. TRAP provides start-up funding for researchers in UCC and its affiliated clinical institutions. TRAP provides access to state-of the-art research facilities & equipment, with the explicit intention of promoting collaborative translational research within the UCC healthcare community.

The purpose of TRAP is to develop meaningful partnerships with UCC colleagues in clinical, pre-clinical and other disciplines relevant to their research areas. It is intended to provide an opportunity for pairs of researchers (one clinician and one non-clinician investigator) to mutually develop new areas of research and to foster them to a point where a more substantial grant application can be made.

Please note that funding will not be awarded to successful applicants until a copy of the ethical approval letter for the project has been submitted to the Medical School.

What can be achieved with the School of Medicine TRAP seed funding?

What can be achieved with the School of Medicine TRAP seed funding? by Drs Suzanne Timmons and Des Murphy.

Publications

Prostaglandin E2 & the EP receptors in malignancy:possible therapeutic targets?

Abstracts: Dr Dervla O' Malley:

R. O’Brien, M.M. Buckley, K.D. O’Halloran, D. O’Malley. A GLP-1 mimetic alleviates Irritable Bowel Syndrome-like symptoms in the Wistar Kyoto rat. EB 2016, April 2016, San Diego, US. (poster presentation).
R. O’Brien and D.O’Malley. Irish Epithelial Physiology Group. Neurocrine effects of GI hormones. October 2015, Kilkenny, Ireland. Invited speakers.
R. O’Brien, M.M. Buckley, D. O’Malley. GLP-1 evokes calcium responses in submucosal neurons, via activation of the JAK/STAT and PI 3-kinase pathways in Sprague Dawley colonic tissue. RAMI, Dublin, June 2015. (poster presentation – POSTER PRIZE)
R. O’Brien, M.M. Buckley and D O’Malley. IBS plasma sensitises colonic submucosal neurons to GLP-1-evoked activation. ESNM, Istanbul, June 2015. (poster presentation)
Kelliher A, O’Sullivan L, Buckley M and O’Malley D. Crosstalk between GLP-1 and IL-6 in isolated rat myenteric and submucosal neurons. RAMI UCC, June 2013. Poster.
DO’Malley. Invited speaker (Rising Stars) to ‘On the constancy of the internal environment – a celebration of Claude Bernard’ hosted by UCC, June 2013. Glucagon-like peptide 1: A potential role in functional bowel disorders.

TRAP recipients 2019

TRAP recipient	TRAP recipient	TRAP receipient	Title
Dr Barry Boland	Prof William Molloy		Investigating the relationship between labile zinc (ZN2+) and zinc amino acid complexes in Alzheimer's disease
Dr Eric Kelleher	Prof John Cryan		Clinical Characteristics, inflammatory markers and microbiota in patients with Functional Neurological disorders receiving a physiotherapy intervention
Dr Aine Merwick	Dr Christian Waeber		Suppressive lymphocyte profiles in patients post stroke/TIA (SLIPS)
Dr Grainne Murphy	Dr Michael T Henry	Dr John MacSharry	Alternations in the lung microbiome in idiopathic pulmonary fibrosis (IPF) pre and post treatment with perfenidone
Dr Elizabeth Brint	Dr Marcus Kennedy		To determine the biological consequences of IL-36 signalling in lung cancer

TRAP Awardees 2018

Trap Awardees 2018

Dr Gerard Clarke

Professor Jonathan Hourihane

Examining changes to infant gut microbiota during oral tolerance induction for cow’s milk allergy.

Dr Aileen Houston

Professor Michael O’Riordain

Death Receptor family members as targets for cancer therapy.

Dr Fiona McDonald

Professor Eugene Dempsey

Professor Ken O’Halloran

A trilogy of stressors in the NICU: Towards a therapy for preterm adversity.

Professor Joe Eustace

Dr Julie O’Neill

Dr Mohammed Abdulla

Gut Dysbiosis and CKD: Cause or Consequence?

Consultant George Finbarr Kaar

Dr Yvonne Nolan

Diagnosis and monitoring of therapeutic response in glioma patients through sequencing of cerebrospinal fluid-derived circulating tumour DNA, micro RNA, and characterisation of plasma-derived extracellular vesicles.

TRAP Awardees 2017

Trap Awardees 2017

Dr Collette Hand

Dr Cynthia Heffron

Characterisation of gene mutations in Irish melanoma patients.

Professor Mary Cahill

Dr Paul Young

Dr Gerardine Meade-Murphy

Hyperactive platelets in Myeloma: a druggable target in the prevention of myeloma-associated thrombosis.

Dr Liam Fanning

Dr Desmond Murphy

Capturing The Allergens of Asthma.

Professor Henry Paul Redmond

Dr André Toulouse

Characterisation of tissue and blood biomarkers of response and progression in a murine model of melanoma brain metastasis following treatment with a combination of Nivolumab and Ipilimumab.

Dr Siobhain O’Mahony

Professor George Shorten

Patient response to lumbar epidural steroid injection for recent onset unilateral radicular low back pain: potential association with gut microbiota diversity and composition.

TRAP Awardees 2016

TRAP Awardees 2016
Dr Elizabeth Brint	Dr Louise Burke	To examine whether expression of IL-36 cytokines are potential biomarkers for progression of lung cancer
Dr Conor Deasy	Dr Simon Woodworth	Can wearable technology be used to continuously measure the vital signs of patients presenting to an emergency department? A pilot study
Dr Sheena McHugh	Dr Kieran O'Connor	Examining the implementation of a falls prevention programme in community hospitals and the factors influencing its success
Dr Conleth Murphy	Dr Kellie Dean	Long, non--‐coding RNA BC200 in ductal carcinoma in situ (DCIS) of the breast: defining a novel biomarker to facilitate early diagnosis

TRAP Awardees 2015

TRAP Awardees 2015
Dr John McSharry	Dr Desmond Murphy	Exploring the role of the Microbiome in Asthma
Dr Justin McCarthy	Dr Michael Bennett	Defining the Expression of tumour-‐associated antigen EpCAM Signalling molecules in primary and metastatic human breast cancers: implications for the definition of novel prognostic subtypes and cancer therapy
Dr Andre Toulouse	Dr Niamh Bermingham	Retinoic acid receptor expression in gliomas
Dr Gerard Clarke	Dr Louise Kenny	Stress-induced Enhanced Gastrointestinal Permeability During Pregnancy: Impact on Maternal Immunology and Tryptophan Metabolism
Dr Dervla O Malley	Dr Juliette Buckley	Does ghrelin sensitise colonic myenteric neurons to the stimulatory effects of Glucagon-like peptide-1?
Dr Frederid Vernimmen	Dr M Morris & Dr JD Holmes	Radiation dose enhancement of endothelial cells by cell membrane located gold nanoparticles

TRAP Awardees 2014

TRAP Awardees 2014
Dr Elizabeth Brint	Dr Michael Bennett	The IL -33/ST2 axis and its potential involvement in human turmorigenesis
Dr Aileen Houston	Dr Paul Redmond	FasL and EP1 recepton.: Novel therapeutic strategies in metastatic colon cancer
Dr Grace O Callaghan	Dr Niall Hyland & Dr Barry O' Reilly	Identification of novel biomarkers and pathophysiological features of bladder pain syndrome
Dr Thomas Murphy	Dr Paul O Toole	The oesophagitis to adenocarcinoma sequence: The role of the microbiome
Dr Gerard O' Keefe	Dr Louise Kenny	To determine the effects and mechanisms by which prenatal stress reduces placntal HSD1182 expression and to develop protective pharmacotherapy for the human placenta
Dr Harriett Schellekens	Dr Derek Power	Neuoendocrine and Gut Microbiome Biomarkers in Pancreatic Cancer Cachexia

TRAP Awardees 2013

TRAP Awardees 2013
Dr Barry Boland	Prof. William Molloy	Novel profiling of multiple amyloid precourssor protein (App) metabolites in cerebrospinal fluid – potential biomarkers for Alzheimer’s disease.
Dr Gerard Clarke	Dr Aoife Ni Chororain	Too Stressed to Care: Attending to the Biological Burden of a Social Responsibility
Dr Eugene Dempsey	Dr Paul Galvin	Facilitating Neonatal Intubation with Chip on Tip Technology
Dr Eric J Downer	Dr Orna O Toole	Interferon-β as a cannabinoid target in Multiple Sclerosis therapy
Dr Peter Filan	Dr Ciara Greene	Brain development in Trisomy 21 at birth: a neonatal magnetic resonance imaging and post-acquisition image processing development study.
Dr Mark Corrigan	Dr Bridget Maher	MEMO - technological Mobility Enabling patient Mobility Outcomes
Dr Andre Toulouse	Dr Brendan Fitzgerald	Investigation of Morphological and Functional Aspects of Syncytiotrophoblast Nuclear Organization Patterns in the Human Placenta

TRAP Awardees 2012

TRAP Awardees 2012
Dr Liam Fanning	Dr Deirdre Murray	Exploring the neonatal virome: A potential window into diseases of unknown or uncharacterised aetiology.
Dr Collette Hand	Dr Aishling Ryan	A Phenotypic & Genotypic Study of Periodic Paralysis in an Irish Population
Dr Janas Harrington	Dr Joe Eustace	Quantification of Dietary Macro/Micronutrient Content using Digital Imaging
Professor Tommie McCarthy	Dr Ted Dinan	Genome Analysis of a Family with a Strong Familial Depression
Dr Tom Moore	Dr James Clover	Use of Human Pregnancy-specific Glycoprotein 1 (PSG1) to promote Wound Healing.
Dr Dervla O'Malley	Dr Eamonn Quigley	Studies to investigate crosstalk between Interleukin-6 and Glucagon-Like Peptide-1 and their influence of the pathophysiology of Irritable Bowel Syndrome
Dr Colm O'Tuathaigh	Dr Ted Dinan	Translational genetic study of microRNAs (miRNA’s) in schizophrenia
Dr Mark Tangney	Dr Deirdre O'Hanlon	Identification of bacterial species naturally present in patient tumours
Dr Suzanne Timmons	Dr Cora O'Neill	Peripheral Akt activity in Parkinsons Disease – a potential biomarker of disease status and response to neuroprotective treatments
Dr Aideen Sullivan	Dr Sean O'Sullivan	Potential biomarkers for Parkinsons disease: comparison of levels of neurotrophic factors in cerebrospinal fluid and serum of Parkinsons disease patients with those in healthy controls