Job Posted: 02 Dec 2016
Closing Date for Applications: 20 Dec 2016
School: APC Microbiome Institute
College: College of Medicine and Health
Contract Type: Fixed Term Whole-Time
Job Type: Academic
Salary: €33,975 - €42,394 (IUA Scale)
Background to Research Environment: The APC Microbiome Institute was formed in 2003 with funding from Science Foundation Ireland and over the last decade the APC Microbiome Institute has established itself as one of the leading global centres in gut microbiota and gut inflammation research. The APC Microbiome Institute has made several landmark discoveries and has published over 1300 research articles in peer-reviewed journals, generating many journal covers and associated editorials. The scientific organisation of the APC Microbiome Institute consists of several integrated research themes or ‘Spokes’ which are supported by multiple shared core technology platforms. The APC Microbiome Institute has significant strengths in microbiology, mucosal immunology, Inflammatory Bowel Disease (IBD) research, bioinformatics, pre-clinical and translational IBD research and is comprised of several multi-disciplinary teams investigating how the gut microbiome interacts with host systems to regulate human health and disease.
Unique Position ID: 7a
Required Qualifications/Experience: PhD (Immunology/Mucosal Immunology) with extensive experience in human immunology/inflammation research and proven ability to conduct independent research to a very high level.
Description of project and role: We are seeking a highly motivated and innovative post-doctoral scientist/immunologist to join the APC’s Gut Inflammation Research Spoke to identify new inflammatory mediators and investigate the specific signalling, epigenetic and transcriptional mechanisms through which pairs of inflammatory mediators synergise to induce inflammatory and anti-microbial gene expression in macrophages. The successful applicant will use various cell and tissue culture systems to discover and validate novel targets in Inflammatory Bowel Disease (IBD) for the development of innovative medicines. The goal of our group is to identify and validate several new therapeutic targets for patients with IBD, including those patients that do not respond satisfactorily to current therapeutic approaches such as anti-TNF biologics. The successful candidate will use cell lines and human primary monocyte derived macrophages to perform various RNAi and phenotypic screens to identify new inflammatory mediators. The person will also investigate the epigenetic and transcriptional mechanisms underpinning synergistic regulation of macrophage inflammatory gene expression using a combination of ChIP-seq, ChIP-qPCR, RNAseq, and qRT-PCR. In this position, the individual is expected to make major scientific laboratory-based contributions to the research goals and milestones of the Gut Inflammation Spoke and will have the opportunity to develop leadership skills by providing mentorship to post-graduates.
- Extensive knowledge of human immunology, inflammation, IBD and human disease research.
- Experience with MACS® cell separation technology, immune cell biology and primary culture of immune cells.
- Significant expertise with flow cytometry and immunophenotyping.
- Significant experience of macrophage biology and primary macrophage cultures.
- Experience with genetic manipulation of macropahges.
- Experience with immune cell biology and primary culture of immune cells.
- Experience with mammalian cell signalling research and epigenetic mechanisms.
- Excellent in vitro and molecular biology skills (cell culture, RNAi, IF, WB, cytokine analysis, ChIP-seq, ChIP-qPCR transcriptomics).
- The candidate should be knowledgeable, highly motivated, creative, and collaborative.
- Excellent verbal and written communication skills.
- Ability to work effectively in a highly collaborative research environment.
- Strong communication and interpersonal skills are required.
- Record of publication in a well-recognized journal(s).
Salary: €33,975 - €42,394
Post Duration: 18 months
Project Title: APC 3 (Unique ID 7a)
Key Duties and Responsibilities
This title will apply to newly qualified Post-Doctoral Researchers and will be considered as a period of training as the researcher will have dual goals in terms of the research project and their own career development. The researcher will be mentored by a Principal Investigator (PI). It is expected that a researcher would spend not more than 3 years at the Post Doctoral level, subject to the term of the project and would then be eligible to compete for a Senior Post Doctoral post advertised by the University.
The primary focus of the Postdoctoral Researcher will be research however a particular emphasis during this stage should include;
- To conduct a specified programme of research under the supervision and direction of a Principal Investigator/Project Leader.
- To engage in appropriate training and professional development opportunities as required by the Principal Investigator, School or College in order to develop research skills and competencies.
- To gain experience in grant writing.
- To engage in the dissemination of the results of the research in which they are engaged, as directed by, with the support of and under the supervision of a Principal Investigator.
- To become familiar with the publication process.
- To acquire generic and transferable skills (including project management, business skills and postgraduate mentoring/supervision).
- To engage in the wider research and scholarly activities of the research group, School or College.
- To interact closely with postgraduate research students who are studying for a Masters or a PhD and possibly have an agreed role in supporting these students in their day to day research in conjunction with an academic supervisor.
- To carry out administrative work to support the programme of research.
- To carry out additional duties as may reasonably be required within the general scope and level of the post.
- To contribute to costing research grant proposals and assist in the financial management of a research project.
- A PhD qualification.
- Appropriate research experience.
- Appropriate technical competence and accomplishment.
- A capability of working within a project team to achieve results.
- Good communication, organisation and interpersonal skills.
- A commitment to gaining practical experience working on a research project.
- Ability to work well within a team.
- Please note that Garda vetting and international police clearance check may form part of the selection process.
For Informal Enquiries on the post candidates should contact:
Name: Dr. Ken Nally
Title: Lecturer in School of Biochemistry and Cell Biology, Funded Investigator, APC
Email Address: email@example.com
Telephone: +353 21 4901302
Please submit a 1 page cover letter quoting the UNIQUE ID:7a, your C.V and the contacts of at least two referees to Email: firstname.lastname@example.org ; Tel:+353 21 4901430, on or before the closing date of Dec 20th 1016
Supplementary Information on the Department/Research Centre and the post is available at the following URL: www.ucc.ie/research/apc
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