Identification of Novel Marine Derived Antimmicrobial Compounds

Identification of Novel Marine Derived Antimmicrobial Compounds

Funding Body: Marie curie transfer of knowledge fellowship

Project Type: Post doc

Period : 01/9/08 – 31/08/10

Researcher: David Lejon

Project Description

My project is a part of TRAMWAYS research programme. TRAMWAYS stands for Transfer of Knowledge in Microbial Signal Transduction Pathways and Metagenomics

TRAMWAYS is a Marie-Curie Transfer of Knowledge funded programme that will run from 2007 until 2010. The strategic goal of the TOK programme is to develop and embed research capabilities at UCC in advanced technologies relevant to bacterial and fungal signal transduction pathways.  The scientific goals of the programme are to (a) acquire new expertise in the use of the zebrafish as an alternative animal model to study pathogenic bacteria and fungi and (b) acquire metagenomic expertise to identify novel bioactive compounds that may influence virulence in human hosts. I’m particularly involved in this latter part.


Lejon DPH, Pascault N & Ranjard L Differential copper impact on density, diversity and resistance of adapted bacterial populations according to soil organic status. Major revision in Microbial ecology

Maron PA, Maitre M, Mercier A, Lejon DPH, Nowak V & Ranjard L (2008) Protein and DNA fingerprinting of a soil bacterial community inoculated in three different sterile soils. Research in Microbiology 159 (4): 231–236. (IF= 2.504)

Lejon DPH , Martins JMF, Lévêque J, Spadini L, Pascault N, Landry D, Milloux MJ, Nowak V, Chaussod R & Ranjard L (2008) Copper Dynamics and Impact on Microbial Communities in soils of Variable Organic Status. Environmental Science and Technology 42 (8): 2819–2825. (IF=4.040)

Lejon DPH , Nowak V, Bouko S, Pascault N, Mougel C, Martins JMF & Ranjard L (2007) Fingerpinting and diversity of bacterial copA genes according to soil types, organic status and copper contamination. FEMS Microbiology Ecology 61 : 424-437. (IF=3.157)

Lejon DPH , Sebastia J, Lamy I, Chaussod R & Ranjard L (2007) Relationships between soil organic status and microbial community density and genetic structure in two agricultural soils submitted to various types of organic management. Microbial Ecology 53: 650-663. (IF=2.332)

Maron PA, Mougel C, Lejon DPH, Carvalho E, Bizet K, Marck G, Cubito N, Lemanceau P & Ranjard L (2006) Temporal variability of airborne bacterial community structure in an urban area. Atmospheric Environment 40: 8074-8080. (IF=2.630)

Ranjard L, Echairi A, Nowak V, Lejon DPH, Nouaim R & Chaussod R (2006) Field and microcosm experiments to evaluate the effects of agricultural Cu treatment on the density and genetic structure of microbial communities in two different soils. FEMS Microbiology Ecology 58: 303-315. (IF=3.157)

Lejon DPH , Chaussod R, Ranger J & Ranjard L (2005) Microbial community structure and density under different tree species in an acid forest soil (Morvan, France). Microbial Ecology 50: 614-625. (IF=2.332)

Maron PA, Lejon DPH, Carvalho E, Carvalho E, Bizet K, Lemanceau P, Ranjard L & Mougel C (2005) Assessing genetic structure and diversity of airborne bacterial communities by DNA fingerprinting and 16S rDNA clone library. Atmospheric Environment 39: 3687-3695. (IF=2.630)

Ranjard L, Lejon DPH, Mougel C, Schehrer L, Merdinoglu D & Chaussod R (2003) Sampling strategy in molecular microbial ecology: influence of soil sample size on DNA fingerprinting analysis of fungal and bacterial communities. Environmental Microbiology 5: 1111-1120. (IF=4.630)


International Patent

Maron PA, Lejon D, Bizet K & Carvalho E Méthode d'extraction d'acides nucléiques et son application dans l'analyse de la population microbienne de l'air. In Numéro de publication: FR2861085. PCT/FR2004/002613

Environmental Research Institute

University College Cork, Lee Road, Cork