Stress related Disorders

Stress related Disorders

Stress related Disorders

Role of early life stress in the development of visceral hypersensitivity

Dr. Siobhain O' Mahony

Early life stress has been associated with visceral hypersensitivity in both rodent and patient studies.  Alterations in the brain-gut axis have been implicated in the increase in sensitivity. Serotonin has both pro-nociceptive and anti-nociceptive actions at the level of the spinal cord via descending projections. Alterations in this balance may result from insults such as stress leading to an enhanced descending facilitatory influence and resulting in visceral hypersensitivity. Using the early life stress model, maternal separation, we aim to assess the impact of this epigenetic phenomenon on the development of an altered pain modulatory system with particular focus on the 5-HT2B receptors.

Stress Related Disorders

Dr Colm Ó Tuathaigh

Research interests to date have focused on the study of gene-gene and gene-environment interactions in genetic models of neuropsychiatric disorders and, in particular, elucidation of the involvement of candidate genes in social and cognitive endophenotypes relevant to psychosis.


Cork NeuroScience CNS Centre - Integrating Clinical and Basic Research

Cork NeuroScien floor,

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