BSc Biochemistry, University College Cork
PhD Supervisor: Prof. Tommie McCarthy
The requirement of cholesterol and lipids in cancer progression is well-characterised. The SREBP pathway regulates expression of genes involved in the de novo synthesis of these molecules. A key component of this pathway is the SREBP cleavage activating protein (SCAP), which regulates proteolytic cleavage and activation of the SREBPs. My research focuses on the role of the SREBP pathway in cancer cell proliferation, with a major focus on further characterisation of SCAP.