BSc Biomedical Sciences, University College Cork
PhD Supervisor: Dr. Paul Young
My research focuses on the differential roles of the non-muscle actinins, isoforms 1 and 4. Discrepancies exist with regard to the roles that these isoforms have in cancer development and progression. Both non-muscle isoforms have been reported to act as tumour promoters and suppressors in different cancer types. In particular, my work examines the localisation and molecular interactions of actinin 1 and 4. The identification and characterisation of actinin-interacting proteins should better aid our understanding of the molecular mechanisms that underlie non-muscle actinin function, leading to cell migration and metastasis.