BA Biochemistry with Cell Biology, Trinity College Dublin
PhD Supervisor: Dr. Cora O'Neill
Several of the signalling pathways underlying cancer pathogenesis are also involved in neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Previous work in our lab and others has shown that Akt/PTEN signal transduction is altered in neurodegeneration. One gene associated within this signalling axis is PTEN-induced kinase 1 (PINK1). Mutations in PINK1 are the second most frequent cause of autosomal recessive Parkinson’s disease. I am interested in the role of this protective kinase and its signalling partners in cancer biology and pathogenesis.