Dr Isabel Fernandez

Position: Postdoctoral Fellow

Email: i.fernandez@ucc.ie

Tel: +353 (0)89 491 0393

Research Interests: 

• Identification and validation of biomarkers in response to IGF-1R targeted therapies and resistance to combination therapy in ovarian cancer.
• Mechanisms of crosstalk between IGF-1R and other signaling pathways, and their contribution in tumour biology.
• Role of the C-terminal region in the regulation of IGF-1R protein complexes and signal output. 

Approach: Molecular and Cell Biology, Biochemistry

Isabel graduated with a PhD in Molecular Cancer Biology from the Cancer Research Centre of Salamanca, Univerisity of Salamanca, and was a member of our laboratory from October 2012 to 2014.

Publications

Fernández, I.F., Blanco S., Lozano J and Lazo PA. (2010). VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. Mol. Cell. Biol.

Isabel F. Fernández, Luis G. Pérez-Rivas, Sandra Blanco, Adrián A. Castillo-Dominguez, José Lozano, and Lazo PA. (2012). VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling. Cell. Mol. Life Sci.

DM Monsalve, T Merced, Fernández I.F., S Blanco, M Vazquez-Cedeira and PA Lazo, (2013). Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression. Cell Death and Disease.