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Growth Factor Receptor at Golgi

2 Jun 2020

A research article from the School was published in the prestigious journal Science Signaling and is also featured in a focus article and on the journal cover.

Leonie Rieger is the first author of this work from the O’Connor group. They discovered that a growth factor receptor, which is normally present on the surface of cells, can under certain conditions relocate to the Golgi apparatus inside cells. Here it helps cancer cells to grow or migrate and avoid drugs that can block the receptor at the cell surface.

The other authors are Grant Godsmark, Sandra O’Shea, Joanna StanickaGeraldine Kelly and Rosemary O’Connor.

The research was funded by Science Foundation Ireland through PI investigator awards.

Leonie Rieger, Sandra O’Shea, Grant Godsmark, Joanna Stanicka, Geraldine Kelly, Rosemary O’Connor (2020) IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr12 13, Science Signaling eaba3176 (2020) 26 May 2020.

Reprint: http://stke.sciencemag.org/cgi/reprint/sigtrans;13/633/eaba3176?ijkey=HIXxzf6q8JnM6&keytype=ref&siteid=sigtrans

FOCUS

The tale of a tail: The secret behind IGF-1R’s oncogenic power.
By Caitrin Crudden, Leonard Girnita. Science Signaling 26 May 2020.

The C-terminal tail of IGF-1R promotes cancer cell migration by mediating adhesion-dependent translocation to the Golgi (Rieger et al., in 26 May 2020 issue).

School of Biochemistry and Cell Biology

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