PhD Positions in Cancer Biology
Job Posted: 26 Jun 2020
Closing Date for Applications: 07 Aug 2020
School: School of Biochemistry and Cell Biology
College: College of Science, Engineering and Food Science
Contract Type: Fixed Term Whole-Time
Job Type: Research
Salary: see advert for details
PhD Positions in Cancer Biology
School of Biochemistry and Cell Biology, University College Cork
Three PhD studentships are available to highly motivated candidates who wish to pursue research in the area of drug resistance, genomic instability or the role of long, non-coding RNAs (lncRNAs) in cancer. These projects will be based in the School of Biochemistry and Cell Biology, UCC which has a strong track record in PhD training and cancer research, with the majority of our graduates subsequently employed in high level academic and biopharmaceutical research and development activity.
Project 1: The endosomal recycling pathway is an intracellular membrane trafficking pathway that delivers cargo to the plasma membrane. In recent years it has emerged that aberrant expression of key regulators of endosomal recycling can lead to the increased aggressiveness of a wide range of cancers. This project will use preclinical in vitro and in vivo models of drug resistant breast cancer to study the possibility of using novel small molecule inhibitors of recycling to overcome drug resistance in cancer.
Project 2: Genomic instability has been long recognized as a hallmark of cancer, however therapeutic strategies to exploit this vulnerability remain challenging. This project will focus on understanding the mechanism(s) underlying genomic instability in preclinical models of breast cancer. In particular, the project aims at investigating how defects in RNA processing contribute to genomic instability. The research will involve a wide range of molecular biology techniques combined with novel genome-wide genomic and proteomic approaches. The overarching goal of this project is to better understand the mechanism(s) underlying genomic instability in cancer and to use this mechanistic insight to develop novel anti-cancer therapies.
For more information about this project please contact Dr Malgorzata Krajewska: email@example.com or see https://www.linkedin.com/in/malgorzata-krajewska-a6479111b/
Project 3: Long, non-coding RNAs (lncRNAs) are a recently discovered class of RNAs greater than 200 nucleotides in length that are transcribed, but with little to no translation into proteins. Due to advances in next generation sequencing technologies, there has been the emergence of lncRNAs as regulators of normal cellular events, with links to various disease states, including cancer. Using a combination of biochemical, molecular and cell biological techniques, this project aims to identify lncRNAs and RNA-binding proteins that interact with lncRNAs to investigate mechanisms by which these complexes can influence cell behaviour in pre-clinical breast and ovarian cancer models. The project will be based in the Dean research group that has local, national and international research and clinical collaborators and is located in the modern, fully-equipped Western Gateway Building at UCC.
For more information about this project, please contact Dr Kellie Dean: K.Dean@ucc.ie or see http://research.ucc.ie/profiles/D003/K.Dean@ucc.ie
We are seeking highly motivated candidates with a minimum 2.1H (or equivalent), BSc or MSc in Biochemistry, Cell Biology, Molecular Biology or related fields.
Student stipend will be €18,000 per annum plus tuition fees. International (non-EU) applications are welcome.
For more information on the School of Biochemistry and Cell Biology see: http://www.ucc.ie/en/biochemistry/
Candidates should submit a detailed CV, a personal statement that outlines research interests, past experience and motivation to complete a PhD (2 pages maximum), and contact information for two academic referees, by email, to: BiochemPhd@ucc.ie
Closing Date for Applications: 7th August 2020.
Starting Date for PhD: 1st October 2020.
University College Cork is an Equal Opportunities Employer