Book of Modules 2008/2009

CBXXXX

Choose by Subject Category or Module Code:
CB7001 Cancer Biology Advanced Laboratory Skills I
CB7002 Cancer Biology Advanced Laboratory Skills II
CB7003 Cancer Biology Advanced Laboratory Skills III
CB7004 Cell and Molecular Biology
CB7005 Human Molecular Genetics and Genetic Engineering Techniques
CB7006 Cancer: Biological and Clinical Perspectives
CB7007 Current Topics in Cancer Biology I
CB7008 Current Topics in Cancer Biology II
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Students should note that all of the modules below may not be available to them.

International visiting students should consult the International Education Office regarding selection of modules.

Undergraduate students should refer to the relevant section of the UCC Undergraduate Calendar for their programme requirements.

Postgraduate students should refer to the relevant section of the UCC Postgraduate Calendar for their programme requirements.

CB7001 Cancer Biology Advanced Laboratory Skills I

Credit Weighting: 15

Teaching Period(s): Teaching Period 1.

No. of Students: Min 5, Max 15.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 1 x 12weeks(s) Other (Laboratory work, self-directed study and seminar).

Module Co-ordinator: Professor Rosemary O'Connor, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry; Staff, College of Medicine and Health.

Module Objective: To provide a hands-on, practical experience in experimental design, implementation, interpretation, and reporting methods used in a biological research laboratory.

Module Content: Each student is required to complete a twelve-week project based on individual research in a selected field of cancer biology, under the supervision of a staff member in the PhD Scholars Programme in Cancer Biology. Results will be compiled in a written project report, formatted as a scientific article, including (i) a summary, (ii) introduction, (iii) methods, (iv) results, (v) discussion, and (vi) references. As part of a mini-symposium, students will formally present their project and results in a 20-minute oral presentation to project supervisors, assessors, and mini-symposium attendees.

Learning Outcomes:

Assessment: Total Marks 300: Continuous Assessment 300 marks (Assessment of student experimental ability, 180 marks; written project report, 90 marks; oral presentation, 30 marks).

Compulsory Elements: Continuous Assessment.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: No End of Year Written Examination.

Requirements for Supplemental Examination: There is no Supplementary Examination.

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CB7002 Cancer Biology Advanced Laboratory Skills II

Credit Weighting: 15

Teaching Period(s): Teaching Period 2.

No. of Students: Min 5, Max 15.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 1 x 12weeks(s) Other (Laboratory work, self-directed study and seminar).

Module Co-ordinator: Professor Rosemary O'Connor, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry; Staff, College of Medicine and Health.

Module Objective: To provide a hands-on, practical experience in experimental design, implementation, interpretation, and reporting methods used in a biological research laboratory.

Module Content: Each student is required to complete a twelve-week project based on individual research in a selected field of cancer biology, under the supervision of a staff member in the PhD Scholars Programme in Cancer Biology. Results will be compiled in a written project report, formatted as a scientific article, including (i) a summary, (ii) introduction, (iii) methods, (iv) results, (v) discussion, and (vi) references. As part of a mini-symposium, students will formally present their project and results in a 20-minute oral presentation to project supervisors, assessors, and mini-symposium attendees.

Learning Outcomes:

Assessment: Total Marks 300: Continuous Assessment 300 marks (Assessment of student experimental ability, 180 marks; written project report, 90 marks; oral presentation, 30 marks.).

Compulsory Elements: Continuous Assessment.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: No End of Year Written Examination.

Requirements for Supplemental Examination: No Supplementary Examination.

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CB7003 Cancer Biology Advanced Laboratory Skills III

Credit Weighting: 15

Teaching Period(s): Teaching/Research Period 3.

No. of Students: Min 5, Max 15.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 1 x 12weeks(s) Other (Laboratory work, self-directed study and seminar).

Module Co-ordinator: Professor Rosemary O'Connor, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry; Staff, College of Medicine and Health.

Module Objective: To provide a hands-on, practical experience in experimental design, implementation, interpretation, and reporting methods used in a biological research laboratory.

Module Content: Each student is required to complete a twelve-week project based on individual research in a selected field of cancer biology, under the supervision of a staff member in the PhD Scholars Programme in Cancer Biology. Results will be compiled in a written project report, formatted as a scientific article, including (i) a summary, (ii) introduction, (iii) methods, (iv) results, (v) discussion, and (vi) references. As part of a mini-symposium, students will formally present their project and results in a 20-minute oral presentation to project supervisors, assessors, and mini-symposium attendees.

Learning Outcomes:

Assessment: Total Marks 300: Continuous Assessment 300 marks (Assessment of student experimental ability, 180 marks; written project report, 90 marks; oral presentation, 30 marks.).

Compulsory Elements: Continuous Assessment.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module:

End of Year Written Examination Profile: No End of Year Written Examination.

Requirements for Supplemental Examination: No Supplementary Examination.

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CB7004 Cell and Molecular Biology

Credit Weighting: 10

Teaching Period(s): Teaching Period 1.

No. of Students: Min 5, Max 30.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 18 x 2hr(s) Lectures; 18 x 1hr(s) Directed Study; Seminars.

Module Co-ordinator: Dr Kellie Dean, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry, Guest Lecturers.

Module Objective: To provide an overview of cell and molecular biology that governs normal and neoplastic cell growth, proliferation, function and death, with an emphasis on analysis of research articles.

Module Content: Eukaryotic DNA replication, repair mechanisms and DNA damage response. Cellular senescence, crisis and cell death by apoptosis. Telomeres and telomerase. Cell cycle regulation, cyclin, cyclin-dependent kinases (CDK), and CDK inhibitors. Eukaryotic transcription, RNA polyermases, promoters, transcription factors and transcripts. RNA processing: capping, splicing and poly-adenylation. Eukaryotic translation: initation, aminoacylation, elongation by ribosomes, and the genetic code. Transcriptional and post-transcriptional gene regulation mechanisms. Post-translational modifications and protein degradation. Growth factor signalling and regulation of signalling pathways. Endocyotsis, cell trafficking, cytoskeleton, cell adhesion and migration.

Learning Outcomes:

Assessment: Total Marks 200: End of Year Written Examination 150 marks (to be taken at end of module); Continuous Assessment 50 marks (Written assignments (2x15 marks; 30 marks total) and in class presentation of research article (20 marks).

Compulsory Elements: End of Year Written Examination; Continuous Assessment.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: 1 x 3 hr(s) paper(s) to be taken in Winter.

Requirements for Supplemental Examination: 1 x 3 hr(s) paper(s) to be taken in Autumn. Marks in passed element(s) of Continuous Assessment are carried forward, Failed element(s) of Continuous Assessment must be repeated (as specified by Module co-ordinator).

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CB7005 Human Molecular Genetics and Genetic Engineering Techniques

Credit Weighting: 5

Teaching Period(s): Teaching Period 2.

No. of Students: Min 5, Max 30.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 12 x 2hr(s) Lectures; 12 x 1hr(s) Directed Study.

Module Co-ordinator: Dr Thomas F Moore, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry, Guest Lecturers.

Module Objective: To achieve an overview of advanced principles and techniques of human molecular genetics and genetic engineering relating to cancer.

Module Content: Genetic alterations in cancer: aneuploidy, gene amplification, translocations, copy number variations; Chromatin alterations in cancer: epigenetics, DNA Methylation, histone acetylation, tumour suppressor promoter hypermethylation, loss of imprinting, influence of dietary components, possible therapies; Inherited susceptibilities in Prostate, Colon, Breast cancer; MicroRNAs: mechanisms, use in diagnosis and prognosis; Genetic tools: microarrays, genomics, proteomics; Animal models: rodents, companion animals; Potential new genetic therapies, vaccination, siRNA; Genetic screens for novel small molecule therapies.

Learning Outcomes:

Assessment: Total Marks 100: End of Year Written Examination 100 marks (to be taken at end of module).

Compulsory Elements: End of Year Written Examination.

Penalties (for late submission of Course/Project Work etc.): None

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: 1 x 1½ hr(s) paper(s) to be taken in Spring.

Requirements for Supplemental Examination: 1 x 1½ hr(s) paper(s) to be taken in Autumn.

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CB7006 Cancer: Biological and Clinical Perspectives

Credit Weighting: 5

Teaching Period(s): Teaching Period 2 and Teaching/Research Period 3. (Module will run from March until May.).

No. of Students: Min 5, Max 30.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 12 x 2hr(s) Lectures; 12 x 1hr(s) Directed Study.

Module Co-ordinator: Professor Rosemary O'Connor, Department of Biochemistry.

Lecturer(s): Staff, College of Medicine and Health, Guest Lecturers and Clinicians.

Module Objective: To provide an overview of the biology of major cancers and the principles underpinning cancer diagnosis and treatment at different stages of progression.

Module Content: Surgical oncology, vascular biology and angiogenesis, medical oncology, and pathology of cancer. Cancer progression and current and potential therapies related to major types of cancers including: breast, colorectal, gynaecological, haematopoietic, lung, oesophageal, and prostate. Cancer diagnostics and treatment, radiology, CT scanning, and radiotherapy.

Learning Outcomes:

Assessment: Total Marks 100: End of Year Written Examination 100 marks (to be taken at end of module).

Compulsory Elements: End of Year Written Examination.

Penalties (for late submission of Course/Project Work etc.): None

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: 1 x 1½ hr(s) paper(s).

Requirements for Supplemental Examination: 1 x 1½ hr(s) paper(s) to be taken in Autumn.

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CB7007 Current Topics in Cancer Biology I

Credit Weighting: 5

Teaching Period(s): Teaching Periods 1 and 2 and Teaching/Research Period 3.

No. of Students: Min 5, Max 30.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 12 x 1hr(s) Seminars; 12 x 1hr(s) Directed Study.

Module Co-ordinator: Dr Kellie Dean, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry.

Module Objective: To analyze primary literature and participate in critical discussions of selected research articles in cancer biology.

Module Content: Each student is required to complete an oral presentation(s) on a selected research topic in cancer biology. The student will be responsible for the selection of a recent, high-quality, research article and will present the findings of the research article to the other module participants. The presentation must include an introduction, descriptions and key findings of each data figure, and the importance and/or relevance of the work to the cancer biology field.

Learning Outcomes:

Assessment: Total Marks 100: Continuous Assessment 100 marks (Oral presentation of selected research article(s): 60 marks; Participation and Attendance: 40 marks.).

Compulsory Elements: Continuous Assessment and Attendance.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: No End of Year Written Examination.

Requirements for Supplemental Examination: No supplementary examination.

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CB7008 Current Topics in Cancer Biology II

Credit Weighting: 5

Teaching Period(s): Teaching Periods 1 and 2 and Teaching/Research Period 3.

No. of Students: Min 5, Max 30.

Pre-requisite(s):

Co-requisite(s):

Teaching Methods: 12 x 1hr(s) Seminars; 12 x 1hr(s) Directed Study.

Module Co-ordinator: Dr Kellie Dean, Department of Biochemistry.

Lecturer(s): Staff, Department of Biochemistry.

Module Objective: To analyze primary literature and participate in critical discussions of selected research articles in cancer biology.

Module Content: Each student is required to complete an oral presentation(s) on a selected research topic in cancer biology. The student will be responsible for the selection of a recent, high-quality, research article and will present the findings of the research article to the other module participants. The presentation must include an introduction, descriptions and key findings of each data figure, and the importance and/or relevance of the work to the cancer biology field.

Learning Outcomes:

Assessment: Total Marks 100: Continuous Assessment 100 marks (Oral presentation of selected research article(s): 60 marks; Participation and Attendance: 40 marks.).

Compulsory Elements: Continuous Assessment and Attendance.

Penalties (for late submission of Course/Project Work etc.): No late submission accepted

Pass Standard and any Special Requirements for Passing Module: 50%.

End of Year Written Examination Profile: No End of Year Written Examination.

Requirements for Supplemental Examination: No Supplementary Examination.

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