|Dr Tom Moore|
Wellcome Trust/HRB 'New Blood' Research Fellow & Statutory Lecturer
Developmental Genetics Laboratory
Department of Biochemistry
University College Cork
Tel: +353 21 490 1339
Fax: +353 21 490 1382
MVB MRCVS (Veterinary Medicine), 1984, University College Dublin.
Ph.D, 1992, University of London
I teach BC3007, an introductory course in Molecular Genetics. An outline of this course and all courses taught by staff in the Department of Biochemistry are available at
UCC Book of Modules.
| I am a principal investigator in the UCC Biosciences
|Maternal-Fetal Interactions: Evolution, Mechanisms & Disease|
|One of our major interests is in understanding aspects of the evolutionary genetics and physiological mechanisms underlying normal and pathological pregnancy in the mouse and human. Currently, we are investigating the function of the Pregnancy-specific glycoprotein (PSG) multigene family (http://www.med.uni-muenchen.de/cea/) using a variety of approaches, including bioinformatics and biochemical approaches, and mouse genome manipulation by transgenesis and gene targeting. We are developing novel transgenic techniques in mice to manipulate placental function in vivo using inducible gene promoters expressed in various trophoblast cell lineages. In collaboration with Prof. T.V. McCarthy, are initiating genetic investigations of human reproductive disorders, which will identify candidate genes for functional analysis in mouse genetic models. We have an ongoing interest in genomic imprinting and in imprinted gene evolution and function (http://www.mgu.har.mrc.ac.uk/imprinting/imprinting.html) , particularly in relation to placental growth in normal pregnancy, and in reproductive disorders such as IUGR and preeclampsia.|
| Moore T.
Genetic conflict, genomic imprinting and establishment of the epigenotype in relation to growth.
Reproduction. 2001 Aug;122(2):185-93.
| Constancia M, Dean W, Lopes S, Moore T, Kelsey G, Reik
Deletion of a silencer element in Igf2 results in loss of imprinting independent of H19.
Nat Genet. 2000 Oct;26(2):203-6.
| Moore T, Mills W.
Imprinting and monogamy.
Nat Genet. 1999 Jun;22(2):130-1.
| Moore T, Constancia M, Zubair M, Bailleul B, Feil R,
Sasaki H, Reik W.
Multiple imprinted sense and antisense transcripts, differential methylation and tandem repeats in a putative imprinting control region upstream of mouse Igf2. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12509-14.
| Moore T, Haig D.
Genomic imprinting in mammalian development: a parental tug-of-war. Trends Genet. 1991 Feb;7(2):45-9