| Teaching |
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I teach BC3007, an introductory course in Molecular
Genetics. An outline of this course and all courses taught by staff
in the Department of Biochemistry are available at
UCC
Book of Modules.
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| Additional Links |
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I am a principal investigator in the UCC Biosciences
Research Institute.
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| Research Interests
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| Maternal-Fetal Interactions: Evolution, Mechanisms
& Disease |
| One of our major interests is in understanding aspects of the evolutionary
genetics and physiological mechanisms underlying normal and pathological
pregnancy in the mouse and human. Currently, we are investigating the function
of the Pregnancy-specific glycoprotein (PSG) multigene family (http://www.med.uni-muenchen.de/cea/)
using a variety of approaches, including bioinformatics and biochemical
approaches, and mouse genome manipulation by transgenesis and gene targeting.
We are developing novel transgenic techniques in mice to manipulate placental
function in vivo using inducible gene promoters expressed in various trophoblast
cell lineages. In collaboration with Prof. T.V. McCarthy, are initiating
genetic investigations of human reproductive disorders, which will identify
candidate genes for functional analysis in mouse genetic models. We have
an ongoing interest in genomic imprinting and in imprinted gene evolution
and function (http://www.mgu.har.mrc.ac.uk/imprinting/imprinting.html) ,
particularly in relation to placental growth in normal pregnancy, and in
reproductive disorders such as IUGR and preeclampsia. |
| Selected Publications |
Moore T.
Genetic conflict, genomic imprinting and establishment of the epigenotype
in relation to growth.
Reproduction. 2001 Aug;122(2):185-93. |
Constancia M, Dean W, Lopes S, Moore T, Kelsey G, Reik
W.
Deletion of a silencer element in Igf2 results in loss of imprinting independent
of H19.
Nat Genet. 2000 Oct;26(2):203-6. |
Moore T, Mills W.
Imprinting and monogamy.
Nat Genet. 1999 Jun;22(2):130-1. |
Moore T, Constancia M, Zubair M, Bailleul B, Feil R,
Sasaki H, Reik W.
Multiple imprinted sense and antisense transcripts, differential methylation
and tandem repeats in a putative imprinting control region upstream of mouse
Igf2. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12509-14. |
Moore T, Haig D.
Genomic imprinting in mammalian development: a parental tug-of-war. Trends
Genet. 1991 Feb;7(2):45-9 |
