Gene-nutrient interactions   

How effects of diet on bone are modulated by individual genetic variation

    EXPECTED ACHIEVEMENT:

      New information on physiological processes mediating the effects of specific genotypes (vitamin D receptor, apolipoprotein E) on bone integrity. This will address the following key questions:  whether the recently discovered increased susceptibility to osteoporosis associated with particular genotypes is mediated through processes which are diet related (e.g. high salt, protein, low vitamin K), and whether dietary strategies can be developed to counter the increased susceptibility to osteoporosis associated with particular genotypes.