Pre-clinical

The APC has expertise in a wide range of preclinical models of bacterial infection (e.g. C. difficile, MRSA, Listeria) and disease (e.g. IBS, obesity, colitis, food allergy), as well as experience in investigating the possible activity of probiotic strains in ameliorating these conditions.

Tools/equipment/techniques:

Inflammation models
- Dextran Sodium Sulphate (DSS) induced colitis
- Citrobacter Rodentium induced colitis
- Leukocyte transfer model
- Neutrophil transfer model
- Thiogycollate activation
- Concavalin A induced hepatic inflammation
- NF-kB reporter mice (lux tagged)
IBS models
- Maternal separation (SD rat)
- Visceral hypersensitivity (WKY rat)
- Anxiety
- Behavioural studies
Infection models
- Listeriosis, Salmonellosis, EPEC, acute Pseudomonas pneumonia, MRSA,C. difficile, citrobacter
Other models
- Obesity – ob/ob mice
- Food allergy
- Respiratory
- Sepsis – caecal ligation
- Endotoxemia (LPS)
- Porcine/bovine
Know-how in house
- Adoptive transfer model (SCID-mice)
- IL-10 knock-out mice

For information contact: Sally Cudmore

Internal APC Preclinical site – Click Here

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