ucc home | site map | Site Feedback
Study at UCC | Current Students | Research | Staff | Teaching & Learning | Visitors | Alumni | About UCC
  • Vascular Biology Laboratory
  • Translational and Clinical Research
  • Experimental Imaging
  • Our Research

     

    Role of progenitor cells post myocardial infarct repair

    The mechanisms underlying repair post MI are still poorly understood and are currently undergoing re-evaluation.

    We have recently shown in a porcine model of MI that post MI repair may be greatly augmented by specific secreted factors from progenitor cells. These factors are the focus of current strategies to alter myocardial remodelling post MI.

    We use state of the art techniques to evaluated progenitor biology post infarction including molecular tagging, transcriptional regulation, bone marrow chimeric models and infarct biology is assessed using immune-histochemistry, biochemical analysis, PV loop display, fluoroscopic angiography and PET-CT with 2D and 3D angiography, functional analysis and molecular chemistry. An additional focus is post vascular injury angiogenesis and arteriogenesis.