Synthetic Organic & Pharmaceutical Chemistry

Synthetic Organic and Inorganic Chemistry

Novel synthetic methodology; Asymmetric synthesis; Synthesis, structure and reactivity of heterocyclic compounds; Organic sulphur and selenium chemistry; Natural product synthesis; Microwave synthesis; Imine and Phosphinoimine complexes of Pd(II) and Pt(II).

Physical Organic Chemistry

Reactive intermediates; Organic reaction mechanisms; Applications of NMR spectroscopy to problems in organic and pharmaceutical chemistry; Conformation and stereodynamics of organic compounds

Medicinal and Pharmaceutical Chemistry

Synthesis of biologically active compounds; Kinase inhibitors for the treatment of cancer; Phytosterols and the toxicity of their oxygenated products; HIV integrase inhibitors and Anti-HIV nucleoside analogues; Novel Metallodrugs.

Analytical and Bioanalytical Chemistry Ionophores for electroanalytical chemistry; Application of LCMS to problems in organic and pharmaceutical chemistry; Mapping of ligand enzyme interactions by mass spectrometry; Impurity profiling of pharmaceutical scale chemistry and illicit drug manufacture.

Pharmaceutical Solid State Crystallisation

Pharmaceutical molecular solids; Powder X-ray Diffraction characterisation of pharmaceutical forms.

Analytical and Biological Chemistry Research Facility

The ABCRF brings together an interdisciplinary  team of synthetic, analytical and bio-chemists in one centre targeted at biomolecule design and detection.

Dr. Stuart Collins Novel organic synthetic methods, small organic molecule synthesis, diazo group chemistry, reactive intermediates, natural product synthesis and microwave assisted reactions
Dr. J.J Keating Medicinal organic chemistry: exploring and characterising the impurities which arise from the synthesis of various drug substances, in particular drugs of abuse.  The synthesis and biological activity of natural products with medicinal properties, and their synthetic analogues
Prof. Anita Maguire Novel synthetic methodology - including the use of diazocarbonyl compounds and organosulfur compounds. Asymmetric synthesis - including biocatalysis and transition metal catalysis.  Design and synthesis of bioactive compounds with pharmaceutical applications.  Crystal engineering.  Extensive interaction with the pharmaceutical industry both within Ireland and overseas is a key feature of the research team
Dr. Dan McCarthy New synthetic methods methods, heterocyclic compounds, chemistry of nitrogen containing functional groups, investigation of reaction mechanisms, biotransformations of organic compounds and NMR spectroscopy
Dr. Florence McCarthy

Indole and carbazole chemistry and their heterocyclic variants; Identification of new molecular templates for drug discovery; Ellipticine derivatives and their mechanism of biological effect; Erb B, Wee 1, and Chk 1 kinase inhibitors for the treatment of cancer; Phytosterols and the toxicity of their oxygenated products; Utilisation of LCMS in the improvement of pharmaceutical process and impurity profiling.  Key to the approach of the group is to identify key novel compounds with interesting potential biology and devise valid routes to their synthesis. Biological evaluation of the compounds produced is undertaken both in-house and via collaboration with researchers in Ireland and abroad

Dr. Gerard McGlacken Synthetic Organic Chemistry, especially of biologically-important molecules (anti-cancer, anti-bacterial and anti-inflammatory properties) and those with useful electronic properties for the semi-conductor industry. Methodology development in Asymmetric Synthesis and Organometallic Chemistry
Dr. Humphrey Moynihan

Solid state aspects of organic chemistry, especially as applied to pharmaceuticals and biological compounds. Topics include crystal and particle engineering, crystal polymorphism, crystal morphology, crystal nucleation and growth, characterisation of crystal form and habit. Systems investigated include sulfanilamides, sugars, aromatics, pigments and other compounds, hence involving both molecular and supramolecular synthesis of these. Much of this work is carried out in collaboration, especially with Dr. Simon Lawrence (crystallography, X-ray diffraction) and through the Solid State Pharmaceutical Cluster

Dr. Tim O'Sullivan New strategies for the total synthesis of biologically active natural products (anti-HIV, anti-parasitic). Development of novel, chiral tethers for the control of intramolecular, aryl-aryl coupling. Organocatalytic preparation of chiral peroxyesters and application to the stereoselective synthesis of natural 1,2-dioxanes
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