BIOMERIT Research Centre Publications
Prof. Fergal O'Gara - Recent Publications (2000 - Present)
2011
Phelan, R.W., Clarke, C., Morrissey, J.P., Dobson, A.D., O'Gara, F., and Barbosa, T.M . (2011). Tetracycline resistance-encoding plasmid from Bacillus sp. #24, isolated from the marine sponge Haliclona simulans . Appl. Environ. Microbiol. 77(1): 327-329. Epub 2010 Nov.
Legendre, C., Mooij, M.J.,
O'Halloran, J.A., Barbosa, T.M., Morrissey, J.P., Kennedy, J., O'Gara, F., and Dobson, A.D.W. (2011). Diversity and antimicrobial activity of Pseudovibrio spp. from Irish marine sponges. J. Appl. Microbiol. 110(6): 1495-1508; PMID: 21435124 .
Barret, M., Egan, F., Fargier, E., Morrissey, J.P., and O'Gara, F. (2011). Genomic analysis of the type VI secretion systems in Pseudomonas spp.: novel clusters and putative effectors uncovered. Microbiology 157(6): 1726- 1 739.
Reen, F.J., Mooij, M.J., Holcombe, L.J., McSweeney, C.M., McGlacken, G.P., Morrissey, J.P., and O'Gara, F. (2011). The Pseudomonas quinolone signal (PQS), and its precursor HHQ, modulate interspecies and interkingdom behaviour. FEMS Microbiol. Ecol. 77(2): 413-428.
Smyth, E.M., McCarthy, J., Nevin, R., Khan, M.R., Dow, J.M., O’Gara, F., and Doohan, F.M. (2011). In vitro analyses are not reliable predictors of the plant growth promotion capability of bacteria; a Pseudomonas fluorescens strain that promotes the growth and yield of wheat. J. Appl. Microbiol. 111(3) : 683-692 (Sept.); PMID: 21672102.
Rice, O., Miller, S.H., Morrissey, J.P, and O’Gara, F. (2011). Exploitation of glucose catabolic gene fusions to investigate in-situ expression during Pseudomonas-Plant interactions. Biol. Fertil. Soils (in press).
Barret, M., Morrissey, J.P., and O’Gara, F. (2011). Functional genomics analysis of plant growth-promoting rhizobacterial traits involved in rhizosphere competence. Biol. Fertil. Soils (in press).
Zhou, L., Glennon, J.D., Luong, J.H.T., Reen, F.J., O’Gara, F., McSweeney, C., and McGlacken, G.P. (2011). Detection of the Pseudomonas Quinolone Signal (PQS) by cyclic voltammetry and amperometry using a boron doped diamond electrode. Chem. Commun. (in press); DOI: 10.1039/C1CC13997E, Communication.
Kennedy, J., O’Leary, N.D., Kiran, G.S., Morrissey, J.P., O’Gara, F., Selvin, J., and Dobson, A.D.W. (2011). Functional metagenomic strategies for the discovery of novel enzymes and biosurfactants with biotechnological applications from marine ecosystems. J. Appl. Microbiol. (in press).
O’Callaghan, J., Reen, F.J.,
Margassery, L.M., Kennedy, J., O'Gara, F., Dobson, A.D, and Morrissey, J.P. Diversity and anti-microbial activity of bacteria isolated from the coastal marine sponges Amphilectus
2010
Baker, P.W., Kennedy, J., Morrissey, J., O’Gara, F., Dobson, A.D.W., and Marchesi, J.R. (2010). Endoglucanase activities and growth of marine-derived fungi isolated from the sponge Haliclona simulans. J. Appl. Microbiol. 108(5): 1668-75.
Miller, S.H., Browne, P., Prigent-Combaret, C., Combes-Meynet, E., Morrissey, J.P., and O’Gara, F. (2010). Biochemical and genomic comparison of inorganic phosphate solubilization in Pseudomonas species. Environ. Microbiol. Reports. 2(3): 403-411.
Kennedy, J., Flemer, B., Jackson, S.A., Lejon, D.P.H., Morrissey, J.P., O’Gara, F., and Dobson, A.D.W. (2010). Review: Marine Metagenomics: New Tools for the Study and Exploitation of Marine Microbial Metabolism. Mar. Drugs 8(3), 608-628.
Mac Aogáin, M., Mooij, M.J., Adams, C., Clair, J., and O’Gara, F. (2010). Emergence of extended-spectrum beta-lactamase and fluoroquinolone resistance genes among Irish multidrug-resistant isolates. Diagn. Microbiol. Infect. Dis. 67(1), 106-109.
Mooij, M.J., O’Connor, H.F., Tian, Z-X., Wang, Y-P., Adams, C., Morrissey, J.P., and O’Gara, F. (2010). Antibiotic selection leads to inadvertent selection of nfxC-type phenotypic mutants in Pseudomonas aeruginosa. Environ. Microbiol. and Environ. Microbiol. Reports 2(3), 461-464.
Holcombe, L.J., McAlester, G., Munro, C.A., Enjalbert, B., Brown, A.J.P., Gow, N.A.R., Ding, C., Butler, G., O’Gara, F., and Morrissey, J.P. (2010). Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans. Microbiology 156(5), 1476–1486
Gleeson, O., O’Gara, F., and Morrissey, J.P. (2010). The Pseudomonas fluorescens secondary metabolite 2,4-diacetylphloroglucinol impairs mitochondrial function in Saccharomyces cerevisiae. Antonie van Leeuwenhoek 97(3): 261-273. Epub 2009 Dec. 20.
McGlacken, G.P., McSweeney, C.M., O’Brien, T., Lawrence, S.E., Elcoate, C.J., Reen, F.J., and O’Gara, F. (2010). Synthesis of 3-halo-analogues of HHQ, subsequent cross-coupling and first crystal structure of Pseudomonas quinolone signal (PQS). Tetrahedron Lett. (in press).
Browne, P., Barret, M., O'Gara, F., and Morrissey, J.P. (2010). Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria. BMC Microbiol. 10(1): 300; PMID: 21108798
2009Kennedy, J., Baker, P., Piper, C., Cotter, P.D., Walsh, M., Mooij, M.J., Bourke, M.B., Rea, M.C., O'Connor, P.M., Ross, R.P., Hill, C., O'Gara, F., Marchesi, J.R., and Dobson, A.D. (2009). Isolation and analysis of bacteria with antimicrobial activities from the marine sponge Haliclona simulans collected from Irish waters. Marine Biotechnol. (NY) May-Jun, 11(3): 384-396.
Moynihan, J.A., Morrissey, J.P., Coppoolse, E.R., Stiekema, W.J., O'Gara, F., and Boyd, E.F. (2009). Evolutionary history of the phl gene cluster in the plant-associated bacterium Pseudomonas fluorescens. Appl. Environ. Microbiol.75(7): 2122-2131.
Cummins, J., Reen, F.J., Baysse, C., Mooij, M.J., and O'Gara, F. Subinhibitory concentrations of the cationic antimicrobial peptide colistin induce the Pseudomonas Quinolone Signal in Pseudomonas aeruginosa. Microbiology 155(9): 2826-2837.
Browne, P., Rice, O., Miller, S.H., Burke, J., Dowling, D.N., Morrissey, J.P., and O'Gara, F. Superior inorganic phosphate solubilization is linked to phylogeny within the Pseudomonas fluorescens complex. Applied Soil Ecology, 43(1): 131-138.
Tian, Z-X., Mac Aogáin, M., O’Connor, H.F., Fargier, E., Mooij, M.J., Adams, C., Wang, Y-P., and O'Gara, F . (2009). MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump. Microb. Pathogenesis 47(4): 237-241.
Tian, Z-X., Fargier, E., Mac Aogáin, M., Adams, C., Wang, Y-P., and O'Gara, F. (2009). Transcriptome profiling defines a novel regulon modulated by theLysR-type transcriptional regulator MexT in Pseudomonas aeruginosa. Nucleic Acids Res. 37(22): 7546-7559 [PMID: 19846594].
2008
Franks, A., Mark-Byrne, G.L., Dow, M.J., and O'Gara, F. (2008). A putative RNA-binding protein has a role in virulence in Ralstonia solanacearum GMI1000. Mol. Plant Pathol. 9(1): 67-72.
Mulcahy, H., O'Callaghan, J., O'Grady, E.P., Maciá, M.D., Borrell, N., Gómez, C., Casey, P.G., Hill, C., Adams, C., Gahan, C.G.M., Oliver, A., and O'Gara, F. (2008). Pseudomonas aeruginosa RsmA plays an important role during murine infection by influencing colonization, virulence, persistence, and pulmonary inflammation. Infect. & Immunity 76(2): 632-638.
Lawongsa, P., Boonkerd, N., Wongkaew, S., O'Gara, F., and Teaumroong, N. (2008). Molecular and phenotypic characterization of potential plant growth-promoting Pseudomonas from rice and maize rhizospheres. World J. Microbiol. Biotechnol. 24(9): 1877-1884.
O'Rourke, K.P., O'Donoghue, G., Adams, C., Mulcahy, H., Molloy, C., Silke, C., Molloy, M., Shanahan, F., and O'Gara, F. (2008). High levels of Lymphotoxin-Beta (LT-Beta) gene expression in rheumatoid arthritis synovium: clinical and cytokine correlations. Rheumatol. Int.28(10): 979-986.
McAlester, G., O'Gara, F., and Morrissey, J.P. (2008). Signal-mediated interactionsbetween Pseudomonas aeruginosa and Candida albican. J. Med. Microbiol. 57: 563-569.
Miller, S.H., Mark, G.L., Franks, A., and O'Gara, F. (2008). Pseudomonas-Plant Interactions. In: Pseudomonas: Model organism, pathogen, cell factory. (Ed. B.H.A. Rehm). Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, pp.353-376.
Kiely, P.D., O'Callaghan, J., Abbas, A., and O'Gara, F. (2008). Genetic analysis of genes involved in dipeptide metabolism and cytotoxicity in Pseudomonas aeruginosa PAO1. Microbiology 154(8): 2209-2218.
McAlester, G., Munro, C.A., Enjalbert, B., Brown, A.J.P., Gow, N.A.R., Ding, C., Butler, G., O'Gara, F. and Morrissey, J.P. (2008).Pseudomonas aeruginosa secreted factors reduce adherence and biofilm formation in Candida albicans(Submitted).
2007
Baysse, C., and O'Gara F. (2007). Role of membrane structure during stress signalling and adaptation in Pseudomonas. In: Pseudomonas: a model system in biology. Vol. V. (Eds. J. Ramos and A. Filloux). Springer-Verlag, New York, pp.193-224.
O'Grady, E.P., Mulcahy, H., Adams, C., Morrissey, J.P., and O'Gara, F. (2007). Manipulation of host Kruppel-like factor (KLF) function by exotoxins from diverse bacterial pathogens.Nat. Rev. Microbiol. 5(5): 337-341.
Abbas, A., Adams, C., Scully, N., Glennon, J., and O'Gara, F. (2007). A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa. FEMS Microbiol. Lett. 274(2): 269-278.
Riedel, C.U., Casey, P.G., Mulcahy, H., O'Gara, F., Gahan, C.G., and Hill, C. (2007). Construction of p16Slux, a novel vector for improved bioluminescent-labelling of Gram negative bacteria. Appl. Environ. Microbiol. 73(21): 7092-7095.
2006
Mulcahy, H., O'Rourke, K.P., Adams, C., Molloy, M.G., and O'Gara, F.(2006). LST1 and NCR3 expression in autoimmune inflammation and in response to IFNg, LPS and microbial infection. Immunogenetics 57(12): 893-903.
Maunsell, B., Adams, C., and O'Gara, F. (2006). Complex regulation of AprA metalloprotease in Pseudmonas fluorescens M114: evidence for the involvement of iron, the ECF sigma factor, PbrA, and pseudobactin M114 siderophore. Microbiology 152: 29-42.
Burrowes, E., Baysse, C., Adams, C., and O'Gara, F.(2006). Influence of the regulatory protein RsmA on cellular functions in Pseudomonas aeruginosa PAO1, as revealed by transcriptome analysis. Microbiology Feb. 152(Pt.2): 405-418.
Mulcahy, H., O'Callaghan, J., O'Grady, E.P., Adams, C., and O'Gara F. (2006). The Post-transcriptional Regulator RsmA plays a Role in the Interaction between Pseudomonas aeruginosa and Human Airway Epithelial Cells by Positively Regulating the Type III Secretion System.Infect. Immun. 74: 3012-3015.
Mark, G.L., Morrissey, J.P., Higgins, P., and O'Gara, F. (2006).Molecular-based strategies to exploit Pseudomonas biocontrol strains for environmental biotechnology applications. FEMS Microbiol. Ecol. 56: 167-177.
Franks, A., Ryan, R., Abbas, A., Mark, L., and O'Gara, F. (2006).Molecular tools for studying plant growth-promoting rhizobacteria (PGPR). In: The Molecular Approaches to Soil, Rhizosphere and Plant Microorganisms. Cooper and Rao (eds). CABI Publishing, Wallingford, Oxfordshire, UK, pp.116-131.
O'Grady, E.P., Mulcahy, H., O'Callaghan, J., Adams, C., and O'Gara, F.(2006). Pseudomonas aeruginosa infection of airway epithelial cells modulates expression of Kruppel-like factors 2 and 6 via RsmA-mediated regulation of type III exoenzymes S and Y. Infect. Immun.74(10): 5893-5902.
Cummins, J., Michel, L., O'Gara F., and Baysse, C. (2006). Envelope-mediated stress signalling in bacteria. In: New research in signal transduction (Ed. G. McAlpine). Nova Science Publishers, New York, pp.123-144.
Kiely, P.D., Haynes, J.M., Higgins, C.H., Franks, A., Mark, G.L., Morrissey, J.P., and O'Gara, F. (2006). Exploiting New Systems-Based Strategies to Elucidate Plant-Bacterial Interactions in the Rhizosphere. Microb. Ecol. 51(3): 257-266.
2005
Mark, G.L., Dow, J.M., Kiely, P., Higgins, H., Haynes, J., Baysse, C., Abbas, A., Foley, T., Franks, A., Morrissey, J., and O'Gara, F. (2005) Transcriptome profiling of bacterial responses to root exudates identifies novel genes involved in microbe-plant interactions. PNAS. 102(48): 17454-17459.
Dandie, C.E., Larrainzar, E., Mark, G.L., O'Gara, F., and Morrissey, J.P. (2005) Establishment of DsRed.T3_S4T as an improved autofluorescent marker for microbial ecology applications. Environmental Biology. 7(11), 1818-1825.
Larrainzar, E., O'Gara F, Morrissey J.P. Applications of autofluorescent proteins for in situ 0studies in microbial ecology. Annu Rev Microbiol. 2005;59:257-77.
Cullinane M, Baysse C, Morrissey JP, O'Gara F. Identification of two lysophosphatidic acid acyltransferase genes with overlapping function in Pseudomonas fluorescens. Microbiology. 2005 Sep;151(Pt 9):3071-3080.
Baysse C, Cullinane M, Denervaud V, Burrowes E, Dow JM, Morrissey JP, Tam L, Trevors JT, O'Gara F. Modulation of quorum sensing in Pseudomonas aeruginosa through alteration of membrane properties. Microbiology. 2005 Aug;151(Pt 8):2529-2542.
Burrowes E, Abbas A, O'Neill A, Adams C, O'Gara F. (2005). Characterisation of the regulatory RNA RsmB from Pseudomonas aeruginosa PAO1. Res Microbiol. 2005 Jan-Feb;156(1):7-16.
2004
Finnan S, Morrissey JP, O'Gara F, Boyd EF. (2004). Genome diversity of Pseudomonas aeruginosa isolates from cystic fibrosis patients and the hospital environment. J Clin Microbiol. Dec;42(12):5783-92.
O'Shea YA, Finnan S, Reen FJ, Morrissey JP, O'Gara F, Boyd EF. (2004). The Vibrio seventh pandemic island-II is a 26.9 kb genomic island present in Vibrio cholerae El Tor and O139 serogroup isolates that shows homology to a 43.4 kb genomic island in V. vulnificus. Microbiology. Dec;150(Pt 12):4053-63.
Mark, G.L., Morrissey, J., Baysse, C., Sweeney, P., and O'Gara, F.(2004). Molecular ecology strategies to investigate the behaviour of GM and non-modified biocontrol inoculants in the rhizosphere. In: Biology of Plant-Microbe Interactions, Vol. 4, [Proceedings of the 11th International Congress on Molecular Plant-Microbe Interactions, St. Petersburg, Russia], (Eds. T. Tikhonovich, B. Lugtenberg, and N. Provorov), IS-MPMI, St. Paul, Minnesota, USA, pp.585-588.
Pühler, A., Arlat, M., Becker, A., Göttfert, M., Morrissey, J.P., and O'Gara, F. (2004), What can bacterial genome research teach us about bacteria-plant interactions? Curr. Opin. Plant Biol. 7(2):137-147.
Abbas, A., McGuire, J.E., Crowley, D., Baysse, C., Dow, M., and O'Gara, F. (2004). The putative permease PhlE of Pseudomonas fluorescens F113 has a role in 2,4-diacetylphloroglucinol resistance and in general stress tolerance. Microbiology 150: 2443-2450.
Morrissey, J.P., Dow, J.M., Mark, G.L., and O'Gara, F. (2004). Are microbes at the root of a solution to world food production? EMBO Rep. Oct;5(10):922-6.
Guihen E, Glennon JD, Cullinane M, O'Gara F. (2004). Rapid analysis of antimicrobial metabolites monoacetylphloroglucinol and 2,4-diacetylphloroglucinol using capillary zone electrophoresis. Electrophoresis. Jun;25(10-11):1536-42.
Morrissey, J.P., Abbas, A., Mark, L., Cullinane, M., and O'Gara, F. (2004). Biosynthesis of antifungal metabolites by biocontrol strains of Pseudomonas. In: The Pseudomonads, Vol. III (Ed. J.L. Ramos), Kluwer Press, pp.635-670.
2003
Walsh, U.F., Moënne-Loccoz, Y., Tichy, H.-V., Gardner, A., Corkery, D.M., Lohrke, S., and O'Gara, F. (2003). Residual impact of the biocontrol inoculant Pseudomonas fluorescens F113 on the resident population of rhizobia nodulating a red clover rotation crop. Microbial Ecol. 45(2): 145-155.
Denison, R.F., Bledsoe, C., Kahn, M., O'Gara, F., Simms, E.L., and Thomashow, L.S.(2003). Cooperation in the rhizosphere and the "free rider" problem. Ecology 84(4): 838-845.
Mark, G.L., Morrissey, J.P., and O'Gara, F. (2003), Designing improved GM bacteria for application in environmental biotechnology. In: Ecological Impact of GMO Dissemination in Agro-Ecosystems, (Proceedings of OECD Workshop, Grossrussbach, Austria), (Eds. T. Lelley, E. Balázs, and M. Tepfer), Facultas Verlags- und Buchhandels AG, Vienna, pp.11-24.
2002
Abbas, A., Morrissey, J.P., Carnicero Marquez, P., Sheehan, M.M., Delany, I.R., and O'Gara, F. (2002). Characterisation of interactions between the transcriptional repressor PhlF and its binding site at the phl A promoter in Pseudomonas fluorescens F113. J. Bacteriol. 184(11): 3008-3016.
Sánchez-Contreras, M., Martín, M., Villacieros, M., O'Gara, F., Bonilla, I., and Rivilla, R. (2002). Phenotypic selection and phase variation occur during alfalfa root colonization by Pseudomonas fluorescens F113. J. Bacteriol. 184: 1587-1596.
Werner, D., Barea, J.M., Brewin, N.J., Cooper, J.E., Katinakis, P., Lindström, K., O'Gara, F., Spaink, H.P., Truchet, G., and Müller, P. (2002). Symbiosis and defence in the interaction of plants with microorganisms. Symbiosis 32(2): 83-104
Morrissey, J.P., Walsh, U.F., O'Donnell, A., Moënne-Loccoz, Y., and O'Gara, F. (2002). Exploitation of genetically modified inoculants for industrial ecology applications. Antonie van Leeuwenhoek 81: 599-606.
2001
Delany, I.R., Walsh, U.F., Ross, I., Fenton, A.M., Corkery, D.M., and O'Gara, F. (2001). Enhancing the biocontrol efficacy of Pseudomonas fluorescens F113 by altering the regulation and production of 2,4-diacetylphloroglucinol.. Plant and Soil 232: 195-205.
Waldron-Lynch, F., Adams, C., Amos, C., Zhu, D.K., McDermott, M.F., Shanahan, F., Molloy, M.G., and O'Gara, F. (2001). Tumour necrosis factor 5’ promoter single nucleotide polymorphisms influence susceptibility to Rheumatoid Arthritis (RA) in immunogenetically defined multiplex RA families. Genes & Immunity 2: 82-87.
Resca, R., Basaglia, M., Poggiolini, S., Vian, P., Bardin, S., Walsh, U.F., Enriquez Barreiros, C.M., O'Gara, F., Nuti, M.P., Casella, S., and Peruch, U. (2001). An integrated approach for the evaluation of biological control of the complex Polymyxa betae/Beet Necrotic Yellow Vein Virus, by means of seed inoculants. Plant and Soil 232: 215-226.
Walsh, U.F., Morrissey, J.P., and O'Gara, F. (2001). Pseudomonas for biocontrol of phytopathogens: from functional genomics to commercial exploitation. Curr. Opin. Biotech. 12(3): 289-295.
Moënne-Loccoz, Y., Tichy, H-V., O'Donnell, A., Simon, R., and O'Gara, F. (2001). Impact of 2,4-diacetylphloroglucinol-producing biocontrol strain Pseudomonas fluorescens F113 on intraspecific diversity of resident culturable fluorescent pseudomonads associated with the roots of field-grown sugar beet seedlings. Appl. Environ. Microbiol. 67(8): 3418-3425.
2000
Heeb, S., Itoh, Y., Nishijyo, T., Schnider, U., Keel, C., Wade, J., Walsh, U., O'Gara, F., and Haas, D. (2000). Small, stable shuttle vectors based on the minimal pVS1 replicon for use in Gram-negative, plant-associated bacteria. MPMI 13(2): 232-237.
Delany, I., Sheehan, M.M., Fenton, A., Bardin, S., Aarons, S., and O'Gara, F. (2000). Regulation of production of the antifungal metabolite 2,4-diacetylphloroglucinol in Pseudomonas fluorescens F113: genetic analysis of phlF as a transcriptional repressor. Microbiology 146: 537-546.
Aarons, S., Abbas, A., Adams, C., Fenton, A., and O'Gara, F. (2000). A regulatory RNA (Prrb RNA) modulates expression of secondary metabolite genes in Pseudomonas fluorescens F113. J. Bacteriol. 182(14): 3913-3919.
Dunne, C., Moenne-Loccoz, Y., de Bruijn, F.J., and O'Gara, F. (2000). Overproduction of an inducible extracellular serine protease improves biological control of Pythium ultimum by Stenotrophomonas maltophilia strain W81. Microbiology 146(8): 2069-2078.
Laue, B.E., Jiang, Y., Chhabra, S.R., Jacob, S., Stewart, G.S.A.B., Hardman, A., Downie, J.A., O'Gara, F., and Williams, P. (2000). The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium "small" bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase. Microbiology 146: 2469-2480.
Walsh, U., O'Gara, F., Economidis, I., and Hogan, S.(2000). Harnessing the potential of genetically modified microorganisms and plants. European Commission Brochure.